WNT7B Information & WNT7B Links at HealthHaven.com

Wingless-type MMTV integration site family, member 7B
Identifiers
Symbols	WNT7B;
External IDs	OMIM: 601967 MGI: 98962 HomoloGene: 22531
Gene ontology
Molecular function	• signal transducer activity; • extracellular matrix structural constituent;
Cellular component	• extracellular region;
Biological process	• Wnt receptor signaling pathway, calcium modulating pathway; • cell-cell signaling; • multicellular organismal development;
Orthologs
NP_478679 (protein)	NP_033554 (protein)

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Protein Wnt-7b is a protein that in humans is encoded by the WNT7B gene.^[1]^[2]^[3]^[4]

The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein which shows 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.^[4]

[edit] References

^ Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (Jun 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res 54 (10): 2615-21. PMID 8168088.
^ van Bokhoven H, Kissing J, Schepens M, van Beersum S, Simons A, Riegman P, McMahon JA, McMahon AP, Brunner HG (Sep 1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization". Cytogenet Cell Genet 77 (3-4): 288-9. PMID 9284940.
^ Kirikoshi H, Sekihara H, Katoh M (Sep 2001). "Molecular cloning and characterization of human WNT7B". Int J Oncol 19 (4): 779-83. PMID 11562755.
^ ^a ^b "Entrez Gene: WNT7B wingless-type MMTV integration site family, member 7B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7477.

[edit] Further reading

Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface.". Mol. Biol. Cell 4 (12): 1267–75. PMID 8167409.
Tanaka K, Okabayashi K, Asashima M, et al. (2000). "The evolutionarily conserved porcupine gene family is involved in the processing of the Wnt family.". Eur. J. Biochem. 267 (13): 4300–11. doi:10.1046/j.1432-1033.2000.01478.x. PMID 10866835.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Capurro MI, Shi W, Sandal S, Filmus J (2006). "Processing by convertases is not required for glypican-3-induced stimulation of hepatocellular carcinoma growth.". J. Biol. Chem. 280 (50): 41201–6. doi:10.1074/jbc.M507004200. PMID 16227623.

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[pmid8168088-0] Huguet EL, McMahon JA, McMahon AP, Bicknell R, Harris AL (Jun 1994). "Differential expression of human Wnt genes 2, 3, 4, and 7B in human breast cell lines and normal and disease states of human breast tissue". Cancer Res 54 (10): 2615-21. PMID 8168088.

[pmid9284940-1] van Bokhoven H, Kissing J, Schepens M, van Beersum S, Simons A, Riegman P, McMahon JA, McMahon AP, Brunner HG (Sep 1997). "Assignment of WNT7B to human chromosome band 22q13 by in situ hybridization". Cytogenet Cell Genet 77 (3-4): 288-9. PMID 9284940.

[pmid11562755-2] Kirikoshi H, Sekihara H, Katoh M (Sep 2001). "Molecular cloning and characterization of human WNT7B". Int J Oncol 19 (4): 779-83. PMID 11562755.

[entrez-3] "Entrez Gene: WNT7B wingless-type MMTV integration site family, member 7B". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7477.

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