Vitamin K epoxide reductase
Identifiers
Symbol	VKORC1
Alt. symbols	VKCFD2
Entrez	79001
HUGO	23663
RefSeq	NM_024006
Other data
Locus	Chr. 16 p11.2

Vitamin K epoxide reductase (VKOR) is an enzyme (EC 1.1.4.1) that reduces vitamin K after it has been oxidised in the carboxylation of glutamic acid. Its C1 subunit (VKORC1) is the target of anticoagulant warfarin.^[1][2]

[edit] References

1. ^ Li T, Chang CY, Jin DY, Lin PJ, Khvorova A, Stafford DW. Identification of the gene for vitamin K epoxide reductase. Nature 2004;427(6974):541-4. PMID 14765195.
2. ^ Rost S, Fregin A, Ivaskevicius V, Conzelmann E, Hortnagel K, Pelz HJ, Lappegard K, Seifried E, Scharrer I, Tuddenham EG, Muller CR, Strom TM, Oldenburg J. Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2. Nature 2004;427(6974):537-41. PMID 14765194.

[edit] See also

• Oxidoreductase

v • d • e Oxidoreductases: alcohol oxidoreductases (EC 1.1) 1.1.1: NAD/NADP acceptor Alcohol dehydrogenase · Aldo-keto reductase (1A1, 1B1, 1B10, 1C1, 1C3, 1C4, 7A2) · Aldose reductase · Carbohydrate dehydrogenases · Carnitine dehydrogenase · DXP reductoisomerase · Glucose-6-phosphate dehydrogenase · Glycerol-3-phosphate dehydrogenase · HMG-CoA reductase · 3-Hydroxyacyl CoA dehydrogenase · Beta-hydroxybutyryl-CoA dehydrogenase · Isocitrate dehydrogenase · IMP dehydrogenase · Β-Ketoacyl ACP reductase · Lactate dehydrogenase · Malate dehydrogenase · Phosphogluconate dehydrogenase · L-threonine dehydrogenase · L-xylulose reductase · Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3 Beta (3-beta-HSD, NSDHL) · 11 Beta (HSD11B1, HSD11B2) · 17 Beta 1.1.2: cytochrome acceptor D-lactate dehydrogenase (cytochrome) · D-lactate dehydrogenase (cytochrome c-553) · Mannitol dehydrogenase (cytochrome) 1.1.3: oxygen acceptor Glucose oxidase · L-gulonolactone oxidase · Xanthine oxidase 1.1.4: disulfide as acceptor Vitamin K epoxide reductase · Vitamin-K-epoxide reductase (warfarin-insensitive) 1.1.5: quinone/similar acceptor Quinoprotein glucose dehydrogenase 1.1.99: other acceptors Choline dehydrogenase · L2HGDH

v • d • e Metabolism of vitamins, coenzymes, and cofactors Fat soluble Vitamin A Retinol binding protein Vitamin D liver (Sterol 27-hydroxylase or CYP27A1) · renal (25-Hydroxyvitamin D3 1-alpha-hydroxylase or CYP27B1) · degradation (1,25-Dihydroxyvitamin D3 24-hydroxylase or CYP24A1) Vitamin K Vitamin K epoxide reductase Water soluble Thiamine (B1) Thiamine pyrophosphokinase Niacin (B3) Indoleamine 2,3-dioxygenase · Formamidase Pantothenic acid (B5) Pantothenate kinase Folic acid (B9) Dihydropteroate synthetase · Dihydrofolate reductase · Serine hydroxymethyltransferase Methylenetetrahydrofolate reductase Vitamin B12 MMAA · MMAB · MMACHC · MMADHC Vitamin C L-gulonolactone oxidase Tetrahydrobiopterin GTP cyclohydrolase I · 6-pyruvoyltetrahydropterin synthase · Sepiapterin reductase PCBD1 · PTS · QDPR see also vitamins, disorders