Vine Street in 1907.

Vine Street functions as Cincinnati's central thorough-fare. It essentially bisects the downtown and Over-the-Rhine neighborhoods. Its heading is mostly north by northeast from the riverfront area through the Over-the-Rhine, ascending between Fairview and Mount Auburn until it courses the uptown plateau past the University of Cincinnati. As the eastern perimeter of the campus and the Environmental Protection Agency's regional offices, Vine is called Jefferson Avenue, though it directly connects with Vine Street on its north and south ends. An adjunct, known as Short Vine, essentially parallels Jefferson Avenue and functions as a central artery of the neighborhood of Corryville, an off-campus mecca. Post-schism Vine descends past the Cincinnati Zoo and the Vine Street Hill Cemetery. Near the bottom of Vine Street Hill, the street leaves the City of Cincinnati and takes a northwestern heading through the independent entities of Saint Bernard, Ivorydale (Manufacturing heart of Procter and Gamble.), Elmwood Place, Carthage, and Hartwell. Before entering Ivorydale, it passes beneath the Mill Creek Expressway, as this segment of Interstate 75 is known. After a railroad crossing in central Ivorydale, it is directly fed into by Spring Grove Avenue. After serving as the municipality of Elmwood Place's central boulevard, Vine takes a northerly heading through the Cincinnati neighborhood of Carthage, where it is joined by Ohio State Route 4 from Paddock Rd. Vine is crossed over by the Interstate 275. Passing on through the Cincinnati neighborhood of Hartwell it becomes Springfield Pike and assumes other local identities as it moves north of Cincinnati as State Route 4 and County Road 767.

Vine Street is the divide between east & west in Cincinnati.