Vibrio cholerae Information & Vibrio cholerae Links at HealthHaven.com

Vibrio cholerae
	TEM image
Scientific classification
Kingdom:	Bacteria;
Phylum:	Proteobacteria;
Class:	Gamma Proteobacteria;
Order:	Vibrionales;
Family:	Vibrionaceae;
Genus:	Vibrio;
Species:	V. cholerae;
Binomial name
	Vibrio cholerae; Pacini 1854

Vibrio cholerae (also Kommabacillus) is a gram negative comma shaped bacterium with a polar flagellum that causes cholera in humans.^[1]^[2] V. cholerae and other species of the genus Vibrio belong to the gamma subdivision of the Proteobacteria.

There are two major biotypes of V. cholerae, classical and El Tor, and numerous other serogroups.

V. cholerae was first isolated as the cause of cholera by Italian anatomist Filippo Pacini in 1854, but his discovery was not widely known until Robert Koch, working independently thirty years later, publicized the knowledge and the means of fighting the disease.^{[citation needed]}

[edit] Genomics and Evolution

The 4.0 Mbp genome of N16961, an O1 serogroup, (in America) El Tor biotype, 7th pandemic strain of V. cholerae, is composed of two circular chromosomes of unequal size that are predicted to encode a total of 3,885 genes^[3]. The genomic sequence of this representative strain has furthered our understanding of the genetic and phenotypic diversity found within the species V. cholerae. Sequence data have been used to identify horizontally acquired sequences, dissect complex regulatory and signaling pathways, and develop computational approaches to predict patterns of gene expression and the presence of metabolic pathway components. Microarrays are being used to study the evolution of the organism. Genomic sequencing of additional strains, subtractive hybridization studies and the introduction of new model systems have also contributed to the identification of novel sequences and pathogenic mechanisms associated with other strains.^[2]

[edit] See also

Cholera

[edit] References

^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0838585299.
^ ^a ^b Faruque SM; Nair GB (editors). (2008). Vibrio cholerae: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-33-2 . http://www.horizonpress.com/vib.
^ Heidelberg, et al. (2000). DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406(6795):477-83

[edit] External links

[Sherris-0] Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed. ed.). McGraw Hill. ISBN 0838585299.

[FaruqueNair-1] Faruque SM; Nair GB (editors). (2008). Vibrio cholerae: Genomics and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-33-2 . http://www.horizonpress.com/vib.

[2] Heidelberg, et al. (2000). DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae. Nature 406(6795):477-83

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Contents

[edit] Genomics and Evolution

[edit] See also

[edit] References

[edit] External links