Mucopurulent discharge is the emission or secretion of fluid containing mucus and pus (Muco pertaining to 'mucus' and purulent pertaining to 'pus') from the eye, nose, cervix, vagina, or other part of the body due to infection and inflammation.

In ophthalmology, mucopurulent discharge from the eyes, and caught in the eyelashes, is a hallmark sign of bacterial conjunctivitis. The normal buildup of tears, mucus, and dirt (compare rheum) that appears at the edge of the eyelids after sleep is not mucopurulent discharge, as it does not contain pus.

Mucopurulent discharge from the cervix/vagina can be indicative of pelvic inflammatory disease, which is associated with N. gonorrhea or Chlamydia. Along with discharge, the woman suffering from PID will also complain of lower abdominal tenderness, bilateral adnexal tenderness and cervical motion tenderness.

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