Uterus
Human female internal reproductive anatomy
1. Round ligament 2. Uterus 3. Uterine cavity 4. Intestinal surface of Uterus 5. Versical surface(toward bladder) 6. Fundus of uterus 7. Body of uterus 8. Palmate folds of cervical canal 9. Cervical canal 10. Posterior lip 11. Cervical os (external) 12. Isthmus of uterus 13. Supravaginal portion of cervix 14. Vaginal portion of cervix 15. Anterior lip 16. Cervix
Gray's	subject #268 1258
Artery	ovarian artery, uterine artery, helicine branches of uterine artery
Vein	uterine veins
Lymph	body and cervix to internal iliac lymph nodes, fundus to para-aortic lymph nodes
Precursor	Müllerian duct
MeSH	Uterus

The uterus (Latin word for womb) is a major female hormone-responsive reproductive sex organ of most mammals, including humans. It is within the uterus that the fetus develops during gestation. The term uterus is used consistently within the medical and related professions; the Germanic term, womb is more common in everyday usage. The plural of uterus is uteruses or uteri.

One end, the cervix, opens into the vagina; the other is connected on both sides to the Fallopian tubes.

[edit] Function

The uterus provides structural integrity and support to the bladder, bowel, pelvic bones and organs. The uterus helps separate and keep the bladder in its natural position above the pubic bone and the bowel in its natural configuration behind the uterus. The uterus is continuous with the cervix, which is continuous with the vagina, much in the way that the head is continuous with the neck, which is continuous with the shoulders. It is attached to bundles of nerves, and networks of arteries and veins, and broad bands of ligaments such as round ligaments, cardinal ligaments, broad ligaments, and uterosacral ligaments [1].

The uterus is essential in sexual response by directing blood flow to the pelvis and to the external genitalia, including the ovaries, vagina, labia, and clitoris. The uterus is needed for uterine orgasm to occur.

The reproductive function of the uterus is to accept a fertilized ovum which passes through the utero-tubal junction from the fallopian tube. It then becomes implanted into the endometrium, and derives nourishment from blood vessels which develop exclusively for this purpose. The fertilized ovum becomes an embryo, develops into a fetus and gestates until childbirth. Due to anatomical barriers such as the pelvis, the uterus is pushed partially into the abdomen due to its expansion during pregnancy. Even during pregnancy the mass of a human uterus amounts to only about a kilogram (2.2 pounds).

[edit] Forms in mammals

In mammals, the four main forms in which it is found are:

Duplex  

There are two wholly separate uteri, with one fallopian tube each. Found in marsupials, rodents (such as mice, rats and guinea pigs), and lagomorpha (rabbits and hares).

Bipartite  

The two uteri are separate for most of their length, but share a single cervix. Found in ruminants (deer, moose, elk etc.), and cats.

Bicornuate 

The upper parts of the uterus remain separate, but the lower parts are fused into a single structure. Found in pigs and dogs.

Simplex  

The entire uterus is fused into a single organ. Found in higher primates (including humans) and horses.

In monotremes, the uterus is duplex, and, rather than nurturing the embryo, secretes the shell around the egg. It is essentially identical with the shell gland of birds and reptiles, with which the uterus is homologous.^[1]

[edit] Anatomy

The uterus is located inside the pelvis immediately dorsal (and usually somewhat rostral) to the urinary bladder and ventral to the rectum. The human uterus is pear-shaped and about 3 in. (7.6 cm) long. A females uterus can be divided anatomically into four segments: The fundus, corpus, cervix and the internal os.

[edit] Regions

From outside to inside, the path to the uterus is as follows:

• Vulva
• Vagina
• Cervix uteri - "neck of uterus"
  • External orifice of the uterus
  • Canal of the cervix
  • Internal orifice of the uterus
• corpus uteri - "Body of uterus"
  • Cavity of the body of the uterus
  • Fundus (uterus)

[edit] Layers

The layers, from innermost to outermost, are as follows:

Endometrium 

The lining of the uterine cavity is called the "endometrium". It consists of the functional endometrium and the basal endometrium from which the former arises. Damage to the basal endometrium results in adhesion formation and/or fibrosis (Asherman's syndrome). In most mammals, including humans, the endometrium builds a lining periodically which is shed or reabsorbed if no pregnancy occurs. Shedding of the functional endometrial lining in humans is responsible for menstrual bleeding (known colloquially as a woman's "period") throughout the fertile years of a female and for some time beyond. In other mammals there may be cycles set as widely apart as six months or as frequently as a few days.

Myometrium 

The uterus mostly consists of smooth muscle, known as "myometrium." The innermost layer of myometrium is known as the junctional zone, which becomes thickened in adenomyosis.

Perimetrium 

The loose surrounding tissue is called the "perimetrium."

Peritoneum 

The uterus is surrounded by "peritoneum."

[edit] Support

The uterus is primarily supported by the pelvic diaphragm,perineal body and the urogenital diaphragm. Secondarily, it is supported by ligaments and the peritoneum (broad ligament of uterus) ^{[2][dead link]}

[edit] Major ligaments

It is held in place by several peritoneal ligaments, of which the following are the most important (there are two of each):

Other named ligaments near the uterus, i.e. the broad ligament, the round ligament, the suspensory ligament of the ovary, the infundibulopelvic ligament, have no role in the support of the uterus.

[edit] Position

Under normal circumstances the uterus is both "anteflexed" and "anteverted." The meaning of these terms are described below:

[edit] Development

The bilateral Müllerian ducts form during early fetal life. In males, MIF secreted from the testes leads to their regression. In females these ducts give rise to the Fallopian tubes and the uterus. In humans the lower segments of the two ducts fuse to form a single uterus, however, in cases of uterine malformations this development may be disturbed. The different uterine forms in various mammals are due to various degrees of fusion of the two Müllerian ducts.

[edit] Sexual response

Stimulation of the uterus can result in an intense orgasm.

[edit] Pathology

Some pathological states include:

• Prolapse of the uterus
• Carcinoma of the cervix – malignant neoplasm
• Carcinoma of the uterus – malignant neoplasm
• Fibroids – benign neoplasms
• Adenomyosis – ectopic growth of endometrial tissue within the myometrium
• Pyometra – infection of the uterus, most commonly seen in dogs
• Uterine malformations mainly congenital malformations including Uterine Didelphys, bicornuate uterus and septate uterus. It also includes congenital absence of the uterus Rokitansky Syndrome
• Asherman's syndrome, also known as intrauterine adhesions occurs when the basal layer of the endometrium is damaged by instrumention (eg. D&C) or infection (eg. endometrial tuberculosis) resulting in endometrial scarring followed by adhesion formation which partially or completely obliterates the uterine cavity.

[edit] Additional images

Schematic frontal view of female anatomy	Uterus and uterine tubes.		Anatomical model of a human pregnancy
Sectional plan of the gravid uterus in the third and fourth month.	Fetus in utero, between fifth and sixth months.	Vessels of the uterus and its appendages, rear view.	Uterus and right broad ligament, seen from behind.
Female pelvis and its contents, seen from above and in front.	Sagittal section of the lower part of a female trunk, right segment.	Posterior half of uterus and upper part of vagina.	The arteries of the internal organs of generation of the female, seen from behind.
Median sagittal section of female pelvis.

[edit] See also

• Hysterectomy
• Menopause
• Uterine glands

[edit] References

1. ^ Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 390-392. ISBN 0-03-910284-X. 
2. ^ ^{a b} The Pelvis University College Cork

[edit] External links

• Female Anatomy: Functions of the Female Organs

Look up uterus in Wiktionary, the free dictionary.

• Gray's s268
• SUNY Labs 43:01-0102 - "The Female Pelvis: Organs in the Female Pelvis in situ"
• Encylopedia.com