Usāma or Osāma, is one of many Arabic male given names for "lion", each denoting some aspect of the animal, it may refer to:

• Osama bin Laden, the leader of al-Qaeda
• Oussama Mellouli, Tunisian swimmer
• Osama (film), a 2003 award-winning film made in Afghanistan
• Osama, the ring name for professional wrestler, Armando Estrada
• Usama Young, New Orleans Saints cornerback
• Usamah ibn Munqidh, 12th century Arab historian, diplomat, and warrior

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