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U.S. Route 421 is a spur of U.S. 21. It runs for 941 miles (1,514 km) from Michigan City, Indiana at U.S. 20 to Fort Fisher. The highway goes through the cities of Indianapolis, Indiana; Frankfort, Kentucky; Lexington, Kentucky; Harlan, Kentucky; Bristol, Tennessee; Winston-Salem, North Carolina; Greensboro, North Carolina; and Wilmington, North Carolina.
[edit] Route description[edit] North CarolinaMain article: U.S. Route 421 in North Carolina U.S. 421 near Winston-Salem. U.S. 421 begins at Fort Fisher and heads through North Carolina's southeastern beaches to Wilmington. It then heads in a northwest direction through Clinton, Dunn, Lillington, Sanford and Siler City to the Piedmont Triad region. In Greensboro, it follows the Greensboro Urban Loop to I-40. After Winston-Salem, it passes through Wilkesboro and Boone (where it intersects the Blue Ridge Parkway) on its way through the mountains towards Bristol, Tennessee. [edit] TennesseeMain article: U.S. Route 421 in Tennessee U.S. 421 near Bristol, Tennessee.
[edit] VirginiaMain article: U.S. Route 421 in Virginia [edit] KentuckyMain article: U.S. Route 421 in Kentucky
U.S. 421 comes from Virginia into Harlan County, Kentucky, and exits at Trimble County at Milton, Kentucky, crossing the Ohio River into Madison, Indiana.
[edit] Indiana
There is a major change to how U.S. 421 intersects with I-74 in Decatur County, Indiana. The Indiana Department of Transportation has conceptual images as well as construction information. http://www.in.gov/indot/div/projects/i74greensburg/ US 421 winds through the southern part of Indiana as it runs from Madison, in the southeastern part of the state, to Indianapolis (the capital). North of Greensburg, US 421 intersects and merges with I-74 west, through the Shelbyville area enroute to Indianapolis. Originally, US 421 followed Southeastern Avenue into downtown Indianapolis, where it merged with US 40 (Washington Street) to West Street, then turned north, following West Street, Northwestern Avenue (later MLK Drive), and Michigan Road up to the northwest side of the city. US 421 went past a famous Indianapolis landmark, the Pyramids. North of Indianapolis, US 421 continues to the north-northwest, providing a direct highway link between Indianapolis and Michigan City. US 421 ends at its junction with US 20 on the south side of Michigan City. [edit] External links
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