North of Ventura, U.S. 101 is an intermittent freeway (i.e. there is occasional cross traffic), but there are no traffic signals until San Francisco. The last traffic signals along this stretch of the route were removed in the early 1990s when the section through downtown Santa Barbara was constructed to freeway standards after years of resistance from the local community.
From San Francisco north the highway is heavily traveled by commuters through to Windsor, just north of Santa Rosa. North of the Golden Gate Bridge, U.S. 101 enters Marin County and is known as the Redwood Highway. After crossing the bridge, U.S. 101 climbs the Waldo Grade and passes through the Waldo Tunnel, the first of its kind in 300 miles (the other being the Gaviota Tunnel in Santa Barbara County), before passing through San Rafael and Novato. The section between Novato in Marin County and Petaluma in Sonoma County changes from its original six or eight lanes through Marin to four lanes, and is thus called the "Novato Narrows" by locals[citation needed]. The entire area between Novato and Petaluma is also the voter approved Novato–Petaluma Community Separator, which forbids most development.[citation needed]
Upon entering Sonoma County it continues as a four lane freeway. It proceeds up the Alexander Valley with the Russian River before leaving Sonoma County and entering Mendocino County.
Instead of terminating in Los Angeles, Highway 101 used to travel all the way south through San Diego to the United States–Mexico border in San Ysidro. However, this part was deleted in the late 1960s in favor of Interstate 5. The only remnant of the old route is a mileage sign at the Santa Barbara/Ventura County line, which lists the distance to San Diego, even though Highway 101 ends in Los Angeles.
| County | Location | Postmile [1][4][5] | #[6] | Destinations | Notes |
Los Angeles LA S0.00-38.19 | Los Angeles | S0.00 | |  I-5 south (Santa Ana Freeway) / SR 60 east (Pomona Freeway) – Santa Ana, Pomona | Southbound exit and northbound entrance |
| 133 | Euclid Avenue | Southbound exit and northbound entrance |
| S0.02 | 1A | Seventh Street | Signed as exit 1A southbound |
| S0.62 | 1A | Fourth Street | Signed as exit 1B southbound; no northbound entrance |
| S0.91 | 1B | First Street | Signed as exit 1C southbound; no southbound entrance |
| 1C | Cesar Chavez Avenue | Northbound exit only |
S1.33 0.00 | 1D | I-10 east (San Bernardino Freeway) – San Bernardino | No southbound entrance; left exit southbound |
| 1E | Mission Road | No northbound exit |
| 0.39 | 2A | Vignes Street | Northbound exit and entrance |
| 0.76 | 2B | Alameda Street – Union Station | |
| 0.87 | 2B | Los Angeles Street | No northbound exit |
| 1.01 | 2C | Spring Street | Northbound exit only |
| 1.08 | 2C | Broadway | Southbound exit and northbound entrance |
| 1.32 | 3A | Grand Avenue, Temple Street | Northbound exit is part of exit 3 |
| 1.62 | 3B | SR 110 (Pasadena Freeway, Harbor Freeway) – Pasadena, San Pedro | Signed as exit 3 northbound; |
| 2.48 | 4A | Glendale Boulevard, Echo Park Avenue, Union Avenue, Belmont Avenue | |
| 2.86 | 4B | SR 2 east (Alvarado Street) | South end of SR 2 overlap |
| 3.34 | 5A | Rampart Boulevard, Benton Way | |
| 3.76 | 5B | Silver Lake Boulevard | |
| 4.40 | 6A | Vermont Avenue | |
| 4.85 | 6B | Melrose Avenue, Normandie Avenue | |
| 5.55 | 7 | SR 2 west (Santa Monica Boulevard) / Western Avenue | North end of SR 2 overlap |
| 6.25 | 8A | Sunset Boulevard | No northbound entrance |
| 6.52 | 8B | Hollywood Boulevard | |
| 6.91 | 8C | Gower Street | |
| 7.06 | 9A | Vine Street | Southbound exit only |
| 7.46 | 9B | Cahuenga Boulevard – Hollywood Bowl | No northbound entrance; signed as exit 9A northbound |
| 7.84 | 9C | Highland Avenue (SR 170 south) – Hollywood Bowl | South end of SR 170 overlap; signed as exit 9B northbound |
| 9.22 | 11A | Barham Boulevard – Burbank | Signed as exit 11 southbound |
| 9.60 | 11B | Universal Studios Boulevard | Northbound exit and entrance; serves Universal Studios Hollywood |
| 10.34 | 12A | Lankershim Boulevard – Universal City | |
| 10.56 | 12B | Ventura Boulevard | No southbound exit |
| 11.11 | 12C | Vineland Avenue | Signed as exit 12B southbound |
| 11.65 | 13B | SR 134 east (Ventura Freeway) – Pasadena | Southbound exit and northbound entrance |
| 11.80 | 13 | SR 170 north (Hollywood Freeway) – Sacramento | North end of SR 170 overlap, northbound exit and southbound entrance |
| 11.83 | 13A | Tujunga Avenue | Southbound exit and northbound entrance |
| 12.85 | 14 | Laurel Canyon Boulevard – Studio City | |
| 13.88 | 15 | Coldwater Canyon Avenue | |
| 14.89 | 16 | Woodman Avenue | |
| 15.91 | 17 | Van Nuys Boulevard | |
| 16.94 | 18 | Sepulveda Boulevard | Northbound exit and southbound entrance |
| 17.17 | 19A | I-405 (San Diego Freeway) – Santa Monica, Sacramento | Former SR 7 |
| 17.50 | 19B | Haskell Avenue | No southbound entrance |
| 18.61 | 20 | Hayvenhurst Avenue | Northbound exit and southbound entrance |
| 19.22 | 21 | Balboa Boulevard – Encino | |
| 20.23 | 22 | White Oak Avenue | |
| 21.25 | 23 | Reseda Boulevard | |
| 22.25 | 24 | Tampa Avenue | |
| 23.26 | 25 | Winnetka Avenue – Woodland Hills | |
| 24.31 | 26A | De Soto Avenue, Serrania Avenue | Signed as exit 26 southbound |
| 24.85 | 26B | Canoga Avenue | Northbound exit and southbound entrance |
| 25.34 | 27 | SR 27 (Topanga Canyon Boulevard) / Ventura Boulevard | Signed as exits 27A (north) and 27B (south) northbound |
| 25.76 | 27C | Shoup Avenue | Northbound exit and southbound entrance |
| 26.45 | 28 | Fallbrook Avenue | Southbound exit only |
| 26.86 | 28 | Woodlake Avenue | Northbound exit and entrance |
| 27.36 | 29 | Mulholland Drive, Valley Circle Boulevard | |
| Calabasas | 28.29 | 30 | Parkway Calabasas | |
| 31.06 | 32 | Las Virgenes Road – Malibu Canyon | |
| 31.92 | 33 | Lost Hills Road | |
| Agoura Hills | 32.79 | 34 | Liberty Canyon Road | |
| 33.69 | 35 | Chesebro Road – Agoura Hills | |
| 35.04 | 36 | Kanan Road | |
| 36.18 | 38 | Reyes Adobe Road | |
| Westlake Village | 37.54 | 39 | Lindero Canyon Road | |
Ventura VEN 0.00-R43.62 | Thousand Oaks | 0.70 | 40 | SR 23 south (Westlake Boulevard) | South end of SR 23 overlap |
| 1.62 | 41 | Hampshire Road | |
| 3.02 | 43A | Rancho Road | Signed as exit 43B northbound |
| 3.11 | 43B | SR 23 north (Moorpark Freeway) – Fillmore | North end of SR 23 overlap; signed as exit 43A northbound |
| 4.06 | 44 | Moorpark Road – Thousand Oaks | |
| 5.05 | 45 | Lynn Road | |
| 6.19 | 46 | Ventu Park Road – Newbury Park | |
| 7.02 | 47A | Rancho Conejo Boulevard, Borchard Road | Signed as exits 47A (Rancho Conejo Boulevard) and 47B (Borchard Road) northbound |
| 7.89 | 47B | Wendy Drive – Newbury Park | Signed as exit 47C northbound |
| Camarillo | 10.74 | 50 | Camarillo Springs Road – Camarillo Grove County Park | |
| 12.30 | 52 | Santa Rosa Road, Pleasant Valley Road | |
| 13.75 | 53A | Flynn Road, Dawson Drive | |
| 13.85 | 53B | SR 34 (Lewis Road) | |
| 14.80 | 54 | Carmen Drive – Camarillo | |
| 15.89 | 55 | Las Posas Road | |
| 17.75 | 57 | Central Avenue | |
| Oxnard | 19.17 | 59 | Del Norte Boulevard | |
| 20.08 | 60 | Santa Clara Avenue, Rice Avenue | |
| 21.01 | 61 | Rose Avenue | |
| 22.01 | 62A | SR 232 (Vineyard Avenue) – Oxnard | |
| 22.73 | 62B | SR 1 south (Oxnard Boulevard) | South end of SR 1 overlap |
| 63A | Ventura Road | Southbound exit only |
| Ventura | R23.45 | 63B | Johnson Drive – Montalvo | Signed as exit 63 northbound |
| R24.65 | 64 | Victoria Avenue – Channel Island Harbor | |
| 25.97 | 65 | Telephone Road | |
| 26.39 | 66A | SR 126 east (Santa Paula Freeway) – Santa Clarita | Signed as exit 66 southbound; no southbound entrance |
| 26.72 | 66B | Main Street (US 101 Bus. north) – Ventura | Northbound exit and entrance |
| 28.45 | 68 | Seaward Avenue | |
| 29.45 | 69 | Vista del Mar Drive, Sanjon Road | Northbound exit and southbound entrance |
| 30.15 | 70A | California Street, Ventura Avenue | |
| 30.91 | 70B | SR 33 north (Ojai Freeway) – Ojai | Former US 399 |
| 31.50 | 71 | Main Street (US 101 Bus. south) – Ventura | Southbound exit and northbound entrance |
| Solimar Beach | R32.70 | 72 | State Beaches (SR 1 north) | North end of SR 1 overlap; northbound exit and southbound entrance |
| Seacliff | R38.98 | 78 | Seacliff (SR 1 south) | South end of SR 1 overlap |
| Gap in freeway |
| R43.57 | 83 | Bates Road | |
Santa Barbara SB R0.00-90.99 | Carpinteria | R0.63 | 84 | SR 150 east – Ojai, Lake Casitas | |
| 1.61 | 85 | Bailard Avenue | |
| 2.64 | 86A | Casitas Pass Road | Signed as exit 86 northbound |
| 3.06 | 86B | Linden Avenue | Southbound exit and northbound entrance |
| 3.77 | 87A | Santa Monica Road | Signed as exit 87 northbound |
| 87B | Carpinteria Avenue | Southbound exit only |
| R5.28 | 88 | Padaro Lane, Santa Claus Lane | |
| R7.14 | 90 | Padaro Lane – Summerland | |
| R8.26 | 91 | Evans Avenue – Summerland | |
| Montecito | 9.00 | 92 | Sheffield Drive | |
| 10.02 | 93 | San Ysidro Road | |
| Santa Barbara | 10.54 | 94A | Olive Mill Road, Coast Village Road | No northbound entrance |
| 94B | Hermosillo Drive | Northbound exit only |
| 11.41 | 94C | Cabrillo Boulevard (SR 225 west), Coast Village Road | Signed as exit 94B southbound |
| 95 | (no name) | Southbound exit only |
| 95 | Salinas Street | Northbound exit and entrance |
| 12.75 | 96A | Milpas Street | Former SR 144 |
| 13.49 | 96B | Laguna Street, Garden Street | |
| R14.19 | 97 | Bath Street, Castillo Street – Santa Barbara Harbor | |
| R14.76 | 98A | Carrillo Street – Downtown Santa Barbara | Signed as exit 98 southbound |
| R15.26 | 98B | Arrellaga Street | Northbound exit and entrance |
| R15.73 | 99A | Mission Street | Signed as exit 99 southbound |
| 99B | Pueblo Street | Northbound exit only |
| 16.55 | 100 | SR 225 east (Las Positas Road) | |
| 17.78 | 101A | La Cumbre Road, Hope Avenue | |
| 18.38 | 101B | SR 154 west / State Street – Cachuma Lake | |
| | 102 | El Sueno Road | Northbound exit and entrance |
| 20.06 | 103 | Turnpike Road | |
| Goleta | 21.15 | 104A | Patterson Avenue | Signed as exit 104 southbound |
| 21.41 | 104B | SR 217 west – Airport, UCSB | Northbound exit and southbound entrance |
| 22.53 | 105 | Fairview Avenue | |
| 23.72 | 107 | Los Carneros Road | |
| 24.77 | 108 | Glen Annie Road, Storke Road | |
| 26.91 | 110 | Winchester Canyon Road, Hollister Avenue | |
| Short gap in freeway |
| 30.06 | 113 | Dos Pueblos Canyon Road | |
| Short gap in freeway |
| 32.84 | 116 | El Capitan Ranch Road | |
| 33.85 | 117 | El Capitan State Beach | |
| 36.62 | 120 | Refugio Road – Refugio State Beach | |
| North end of freeway |
| 44.82 | 128 | Mariposa Reina | Interchange |
| | | Gaviota State Beach | |
| 47.19 | Gaviota Gorge Tunnel (northbound only) |
| South end of freeway |
| Las Cruces | R48.85 | 132 | SR 1 north – Lompoc, Vandenberg AFB | North end of SR 1 overlap |
| Gap in freeway |
| Buellton | R56.46 | 139 | Santa Rosa Road | |
| R57.12 | 140A | SR 246 – Lompoc, Solvang | |
| R57.55 | 140B | McMurray Road, Avenue of the Flags | |
| Gap in freeway |
| Zaca | 62.67 | 146 | SR 154 east / Zaca Station Road – Los Olivos, Cachuma Lake | |
| Gap in freeway |
| 70.92 | 154 | SR 135 north – Los Alamos, Vandenberg AFB | |
| Gap in freeway |
| 78.69 | 161 | (no name) | |
| Santa Maria | 82.18 | 164 | Clark Avenue – Orcutt | |
| 84.34 | 167 | Santa Maria Way (US 101 Bus. north) | |
| 86.59 | 169 | Betteravia Road – Sisquoc | |
| 87.60 | 170 | Stowell Road | |
| Santa Maria | 88.60 | 171 | SR 166 west (Main Street) – Santa Maria, Guadalupe | South end of SR 166 overlap |
| 89.69 | 172 | Donovan Road | |
| 90.75 | 173 | SR 135 south (Broadway, US 101 Bus. south) – Santa Maria | |
San Luis Obispo SLO 0.00-R69.32 | | 0.81 | 175 | SR 166 east – Maricopa, Bakersfield | North end of SR 166 overlap |
| 4.85 | 179 | Tefft Street – Nipomo | |
| 7.84 | 182 | Thompson Road, Los Berros Road | |
| Gap in freeway |
| Arroyo Grande | 12.52 | 186 | Traffic Way (US 101 Bus. north), Fair Oaks Avenue | No northbound entrance |
| 13.17 | 187A | SR 227 north (Grand Avenue, US 101 Bus. south) | |
| 13.75 | 187B | Brisco Road, Halcyon Drive | |
| Pismo Beach | 14.61 | 188 | Oak Park Road | |
| 15.58 | 189 | 4th Street, Five Cities Drive | Signed as exits 189 (4th Street) and 190A (Five Cities Drive) southbound |
| 16.40 | 190B | Price Street (US 101 Bus. north), Hinds Avenue | No northbound entrance; signed as exit 190 northbound |
| 16.88 | 191A | SR 1 south / Wadsworth Avenue – Pismo Beach | No southbound entrance |
| 17.76 | 191B | Shell Beach Road, Price Street (SR 1 south, US 101 Bus. south) | South end of SR 1 overlap |
| R19.81 | 193 | Spyglass Drive, Shell Beach Road | |
| R21.11 | 195 | Avilla Beach Drive | |
| R22.29 | 196 | San Luis Bay Drive – See Canyon, Avila Beach | |
| R24.30 | 198 | Higuera Street | |
| San Luis Obispo | 25.91 | 200A | Los Osos Valley Road | Signed as exit 200 southbound |
| 200B | Prado Road, Elks Lane | Northbound exit and entrance |
| 27.50 | 201 | SR 227 south (Madonna Road) | |
| 28.07 | 202A | Marsh Street | |
| 28.81 | 202B | Broad Street | |
| 29.08 | 203A | Osos Street, Santa Rosa Street | |
| 29.08 | 203B | SR 1 north – Morro Bay, Hearst Castle | North end of SR 1 overlap |
| 29.40 | 203C | California Boulevard | |
| 29.77 | 203D | Grand Avenue – Cal Poly | Northbound exit and southbound entrance |
| 29.99 | 204 | Monterey Street | No southbound entrance |
| Gap in freeway (Cuesta Grade) |
| Santa Margarita | 37.85 | 211 | SR 58 east – Santa Margarita | |
| 42.27 | 216A | Santa Barbara Road | Signed as exit 216 southbound |
| | 216B | San Diego Way | Northbound exit and southbound entrance |
| Atascadero | 44.01 | 218A | Santa Rosa Road | |
| 44.84 | 218B | Curbaril Avenue | |
| 45.57 | 219 | SR 41 (Morro Road) | |
| 45.96 | 220A | Traffic Way (US 101 Bus. north) | |
| 46.87 | 220B | San Anselmo Road | |
| 48.33 | 222 | Del Rio Road (US 101 Bus. south) | |
| 49.32 | 223 | San Ramon Road, Santa Cruz Road | |
| Templeton | 50.64 | 224 | Vineyard Drive (US 101 Bus. north) | |
| 51.45 | 225 | Las Tablas Road | |
| 52.44 | 226 | Main Street (US 101 Bus. south) | |
| Paso Robles | 53.89 | 228 | SR 46 west – Cambria, Hearst Castle | South end of SR 46 overlap |
| 55.67 | 229 | Spring Street (US 101 Bus. north) | Northbound exit and southbound entrance |
| 230 | Pine Street | Southbound exit and entrance |
| 230 | Paso Robles Street | Northbound exit only |
| 56.88 | 231A | 16th Street | Southbound exit and northbound entrance |
| 57.92 | 231B |  SR 46 east / CR G14 – Fresno, Bakersfield | North end of SR 46 overlap; signed as exit 231 northbound |
| 58.76 | 232 | Spring Street (US 101 Bus. south) | No southbound entrance |
| Gap in freeway |
| San Miguel | 65.08 | 239A | San Miguel | Northbound exit and southbound entrance |
| 65.56 | 239B | 10th Street | Signed as exit 239 southbound |
| 67.23 | 241A | San Miguel | Southbound exit and northbound entrance |
| R67.71 | 241B | Camp Roberts | Signed as exit 241 northbound |
Monterey MON R0.00-101.32 | | R0.84 | 244 | Camp Roberts | |
| R2.15 | 245 | East Garrison | |
| R7.94 | 251 | Bradley | |
| R9.67 | 252 | CR G18 (Jolon Road) – Fort Hunter Liggett | |
| R15.47 | 258 | Alvarado Road | |
| R17.86 | 260 | Los Lobos Road | |
| R21.99 | 263 | Paris Valley Road – San Ardo | |
| R29.90 | 271 | Paris Valley Road – Lockwood | |
| San Lucas | R32.02 | 273 | SR 198 east – San Lucas, Coalinga | |
| R37.31 | 278 | Wild Horse Road | |
| King City | R39.77 | 281 | First Street (US 101 Bus. north, CR G13, CR G15) – King City | |
| R40.72 | 282A | Canal Street | |
| R41.18 | 282B | Broadway (US 101 Bus. south) – King City | |
| R41.95 | 283 | CR G14 (Jolon Road) – Fort Hunter Liggett | |
| North end of freeway |
| | | Central Avenue | |
| South end of freeway |
| 52.66 | 293 | Espinosa Road (US 101 Bus. north, CR G16) – Greenfield | |
| Greenfield | 53.36 | 294A | Oak Avenue | |
| 53.86 | 294B | Walnut Avenue | |
| 54.79 | 295 | Thorne Road (US 101 Bus. south) – Greenfield | |
| Gap in freeway |
| 60.40 | 301 | Arroyo Seco Road | |
| Soledad | 61.59 | 302 | SR 146 (US 101 Bus. north) – Soledad | |
| 62.70 | 303 | Front Street (US 101 Bus. south) | |
| 64.63 | 305 | Camphora Gloria Road | |
| 66.40 | 307 | Soledad Correctional Facility | |
| 69.37 | 310 | Gloria Road (US 101 Bus. north) – Gonzales | |
| 70.86 | 311 | 5th Street | |
| 72.61 | 313 | Old Stage Road (US 101 Bus. south) – Gonzales | |
| 76.97 | 317 | Chualar | |
| North end of freeway |
| 82.47 | | Abbott Street (US 101 Bus. north) – Spreckels | Interchange; northbound exit and southbound entrance |
| South end of freeway |
| Salinas | 85.62 | 326A | Airport Boulevard | |
| 326B | Fairview Avenue | Northbound exit only |
| 86.12 | 326C | Monterey Peninsula | Signed as exit 326B southbound |
| 86.82 | 327 | John Street (SR 68) | |
| 87.30 | 328 | To SR 183 (Market Street) – Santa Cruz | |
| 329 | North Main Street (US 101 Bus. north) | Northbound exit and southbound entrance |
| R88.24 | 329 | Main Street (SR 183, US 101 Bus. south) – Salinas | Southbound exit and northbound entrance |
| R89.27 | 330 | Laurel Drive | |
| R91.01 | 331 | Boronda Road (US 101 Bus. south) | |
| North end of freeway |
| R91.90 | | Russell Road | Interchange; northbound exit and entrance |
| 91.90 | | Espinosa Road | No northbound entrance |
| 95.44 | 336 | SR 156 west / Vierra Canyon Road – Monterey Peninsula | Interchange; south end of SR 156 overlap |
| 96.14 | 337 | San Miguel Canyon Road (CR G12) | Interchange |
| 100.39 | | Dumbarton Road to San Juan Road (CR G11) – Aromas, Watsonville | No northbound entrance |
| | | San Juan Road (CR G11) – Aromas, Watsonville | No northbound exit |
San Benito SBT 0.00-R7.52 | South end of freeway |
| 3.01 | 345 | SR 156 east – San Juan Bautista, Hollister | North end of SR 156 overlap |
| R4.90 | 347 | SR 129 west – Watsonville, Santa Cruz | |
| R6.49 | 349 | Betabel Road, Y Road | |
| North end of freeway |
Santa Clara SCL R0.03-52.55 | | 3.16 | 353 | SR 25 south – Hollister, Pinnacles National Monument | Interchange |
| | | Gavilan College | No left turn from US 101 north to Gavilan College |
| South end of freeway |
| R4.94 | 355 | Monterey Street (US 101 Bus. north) – Gilroy | |
| Gilroy | R6.08 | 356 | SR 152 east (Pacheco Pass Road) / 10th Street | South end of SR 152 overlap |
| R7.53 | 357 |  SR 152 west / CR G9 (Leavesley Road) – Gilroy | North end of SR 152 overlap |
| R10.27 | 360 | Masten Avenue | |
| R12.46 | 362 | San Martin Avenue | |
| R15.07 | 365 | Tennant Avenue | |
| Morgan Hill | R16.01 | 366 | East Dunne Avenue – Morgan Hill | |
| R17.82 | 367 | Cochrane Road (US 101 Bus. south) | |
| San Jose | R21.25 | 371 | Coyote Creek Golf Drive | |
| R23.10 | 373 | Bailey Avenue | |
| R26.78 | 377A | SR 85 north (West Valley Freeway) – Mountain View, Cupertino | Signed as exit 377B southbound; no northbound entrance |
| R27.00 | 377B | Silicon Valley Boulevard, Bernal Road | Signed as exit 377A southbound |
| R28.61 | 378 | SR 82 (Blossom Hill Road) / Silver Creek Valley Road | |
| 30.10 | 380 | Hellyer Avenue | |
| 31.00 | 381 | Yerba Buena Road | Southbound exit is part of exit 382 |
| 31.70 | 382 | Capitol Expressway (CR G21) | |
| 33.03 | 383 | Tully Road | |
| 34.55 | 385A | Story Road | Signed as exit 385 northbound |
| 34.87 | 385B |  I-280 north / I-680 north – San Francisco, Downtown San Jose, Sacramento | Signed as exit 384 northbound |
| R35.76 | 386A | SR 130 (Alum Rock Avenue) / Santa Clara Street | |
| R36.14 | 386B | McKee Road, Julian Street | |
| 37.73 | 388A | Oakland Road, 13th Street | Former SR 238 |
| 38.30 | 388 | I-880 (Nimitz Freeway) – Oakland, Santa Cruz, Los Gatos | Signed as exits 388B (north) and 388C (south) |
| 38.80 | 389A | Old Bayshore Highway | Northbound exit and entrance |
| 39.29 | 389B | Brokaw Road, First Street | Signed as exit 389 southbound |
| 39.93 | 390 | SR 87 south (Guadalupe Freeway) | Southbound exit and northbound entrance |
| 40.70 | 391 | Trimble Road, De la Cruz Boulevard – Santa Clara | Signed as exits 391A (Trimble Road) and 391B (De la Cruz Boulevard) southbound |
| Santa Clara |
| 41.98 | 392 | San Tomas Expressway, Montague Expressway (CR G4) | |
| 42.73 | 393 | Great America Parkway, Bowers Avenue | |
| Sunnyvale | 43.85 | 394 | Lawrence Expressway (CR G2) | |
| 44.83 | 395 | Fair Oaks Avenue | Signed as exits 395A (north) and 395B (south) southbound |
| 45.68 | 396A | Malthilda Avenue north to SR 237 east | Northbound exit and southbound entrance |
| 45.68 | 396B | Mathilda Avenue south – Sunnyvale | Signed as exit 396A southbound; former SR 85 |
| 46.13 | 396B | SR 237 east – Alviso, Milpitas | Southbound exit and northbound entrance |
| 46.13 | 396C | SR 237 west (Mountain View Alviso Road) | Northbound exit and southbound entrance |
| Mountain View | 47.01 | 397 | Ellis Street | |
| 47.89 | 398A | Moffett Boulevard, NASA Parkway | Signed as exit 398 northbound |
| 48.10 | 398B | SR 85 south (Stevens Creek Freeway) – Cupertino, Santa Cruz | Southbound exit and northbound entrance |
| 48.60 | 399A | Shoreline Boulevard – Mountain View | Signed as exit 399 southbound |
| 48.97 | 399B | Old Middlefield Way | Northbound exit and southbound entrance |
| 49.61 | 400A | Amphitheatre Parkway, Rengstorff Avenue | Signed as exits 400A (Amphitheatre Parkway) and 400B (Rengstorff Avenue) northbound |
| 50.32 | 400C | San Antonio Road | Signed as exits 400B (north) and 400C (south) southbound |
| Palo Alto |
| 52.01 | 402 | Oregon Expressway (CR G3) | |
| 52.17 | 402 | Embarcadero Road | |
San Mateo SM 0.00-26.11 | East Palo Alto | 0.89 | 403 | University Avenue (to SR 109) | |
| 1.87 | 404 | Willow Road (SR 114, to SR 84) | Signed as exits 404A (east) and 404B (west) |
| Menlo Park |
| 3.59 | 406 | SR 84 east (Marsh Road) – Dumbarton Bridge | South end of SR 84 overlap |
| Redwood City | 5.39 | 408 | SR 84 west (Woodside Road) / Seaport Boulevard | North end of SR 84 overlap |
| 6.62 | 409 | Whipple Avenue– Redwood City | |
| San Carlos | | 411 | Brittan Avenue | Southbound exit and entrance |
| 8.40 | 411 | Holly Street, Redwood Shores Parkway – San Carlos | |
| | 412 | Harbor Boulevard | Southbound exit and entrance |
| Belmont | 9.55 | 412 | Marine Parkway, Ralston Avenue – Belmont | Former Legislative Route 214 |
| San Mateo | 11.15 | 414A | Hillsdale Boulevard – Foster City | |
| 11.90 | 414B | SR 92 – Hayward, San Mateo Bridge, Half Moon Bay | |
| 11.90 | 414B | Fashion Island Boulevard | No northbound exit |
| 12.69 | 415 | Kehoe Avenue | Northbound exit and entrance |
| 13.46 | 416 | 3rd Avenue | Former SR 92 |
| 14.33 | 417A | Dore Avenue | Northbound exit |
| 14.33 | 417 | Poplar Avenue | Southbound exit and entrance |
| 14.69 | 417B | Peninsula Avenue – Burlingame | Northbound exit and entrance |
| Burlingame | | 419A | Anza Boulevard | Northbound exit and entrance |
| 16.58 | 419B | Broadway – Burlingame | |
| Millbrae | 17.95 | 420 | Millbrae Avenue – Millbrae | |
| San Bruno | 19.12 | 422 | San Francisco International Airport | Southbound exit is part of exit 423A |
| R20.39 | 423A | San Bruno Avenue | |
| R20.72 | 423B |  I-380 west to I-280 – San Bruno | |
| South San Francisco | R20.72 | 423C | North Access Road – North Cargo Area | Southbound exit is part of exit 423A |
| 21.69 | 424 | South Airport Boulevard | |
| 21.92 | 425A | Grand Avenue – Downtown South San Francisco | No southbound entrance |
| 22.71 | 425B | Oyster Point Boulevard | |
| 425C | South San Francisco (Airport Boulevard) | Southbound exit and entrance |
| Brisbane | 23.39 | 426A | Brisbane, Cow Palace (Bayshore Boulevard) | Northbound exit only |
| 23.66 | 426B | Sierra Point Parkway, Marina Boulevard – Brisbane | Signed as exit 426 southbound; southbound exit and entrance are located 1.2 miles (1.9 km) north of northbound exit and entrance |
San Francisco SF 0.00-11.18 | 0.03 | 429A | Tunnel Avenue – Candlestick Park | |
| 0.77 | 429B | Third Street – Cow Palace | |
| 1.11 | 429C | Paul Avenue | No northbound entrance; signed as exit 430A southbound |
| 1.77 | 430B | Silver Avenue | No northbound entrance |
| 1.98 | 430A | I-280 north – Downtown San Francisco | Northbound exit and southbound entrance |
| 1.98 | 430A | I-280 south – Daly City | Signed as exit 431 southbound |
| 2.00 | 431 | Alemany Boulevard, Bayshore Boulevard | No southbound exit |
| 2.92 | 432 | Cesar Chavez Street, Potrero Avenue | |
| 4.10 | 433A | Vermont Street | Northbound exit only |
| 4.24 | 433B | I-80 east (James Lick Freeway) – Bay Bridge, Oakland | Signed as exit 433 southbound |
| 433C | Ninth Street – Civic Center | Northbound exit and southbound entrance |
| 434A | Duboce Avenue | Northbound exit and southbound entrance |
| 434B | Octavia Boulevard to Fell Street | Northbound exit and southbound entrance |
| North end of freeway |
| R5.07 | | Mission Street, Otis Street | |
| | Market Street | |
| 6.71 | | Van Ness Avenue, Lombard Street – Fisherman's Wharf | |
| 7.80 | | Broderick Street, Lombard Street, Richardson Avenue – Presidio | |
| South end of freeway |
| | Presidio, Crissy Field | Northbound exit only |
| L8.59 | 437 | Marina Boulevard – Marina | Southbound exit and northbound entrance |
| 9.40 | 438 | SR 1 south (19th Avenue) – Golden Gate Park | South end of SR 1 overlap |
| 9.71 | 439 | 25th Avenue – View Area, Presidio, Golden Gate NRA, Fort Point | |
| Golden Gate Bridge over Golden Gate |
Marin MRN L0.00-27.63 | Sausalito |
| | Vista Point | Northbound exit and entrance |
| 0.32 | 442 | Alexander Avenue – Sausalito | |
| 0.89 | Waldo Tunnel under Waldo Grade |
| 1.52 | 443 | Spencer Avenue, Monte Mar Drive | |
| 2.48 | 444 | Rodeo Avenue | No access across US 101 |
| 3.33 | 445A | Sausalito, Marin City | |
| 4.46 | 445B | SR 1 north – Mill Valley, Stinson Beach | North end of SR 1 overlap |
| Strawberry | | 446 | Seminary Drive | |
| 5.70 | 447 | SR 131 east (Tiburon Boulevard) / East Blithedale Avenue | |
| Corte Madera | 7.37 | 449A | Paradise Drive, Tamalpais Drive | Signed as exit 449 northbound |
| 7.66 | 449B | Madera Boulevard | Southbound exit and entrance |
| 8.02 | 450A | Lucky Drive, Doherty Drive | |
| Larkspur | 8.60 | 450B | Sir Francis Drake Boulevard – San Anselmo, Richmond Bridge, Kentfield | |
| San Rafael | 9.63 | 451A | Andersen Drive | Southbound exit and entrance |
| 10.00 | 451 | Francisco Boulevard to I-580 east – Richmond Bridge | Northbound exit only |
| 10.00 | 451B | I-580 east – Richmond Bridge, Oakland | Southbound exit and northbound entrance |
| 10.72 | 452 | Central San Rafael | |
| 12.19 | 454A | Lincoln Avenue | No northbound exit |
| 12.69 | 454B | North San Pedro Road | Signed as exit 454 northbound |
| 13.71 | 455 | Freitas Parkway – Terra Linda | |
| 14.71 | 456 | Lucas Valley Road, Smith Ranch Road | |
| 15.57 | 457 | St. Vincent Drive – Marinwood | |
| 16.64 | 458 | Nave Drive, Alameda del Prado – Hamilton Field | |
| 18.09 | 459 | Ignacio Boulevard, Bel Marin Keys Boulevard, Entrada Drive – Hamilton Field | |
| Novato | 18.94 | 460 | SR 37 east / South Novato Boulevard – Napa, Vallejo | Signed as exits 460A (SR 37) and 460B (South Novato Boulevard) northbound |
| R20.19 | 462A | Rowland Boulevard (US 101 Bus. north) | |
| R21.11 | 462B | De Long Avenue – Downtown Novato | |
| R22.00 | 463 | Atherton Avenue, San Marin Drive (US 101 Bus. south) | |
| North end of freeway |
| 26.90 | | San Antonio Road | No northbound entrance |
Sonoma SON 0.00-R56.22 | | | | San Antonio Road | Interchange; no northbound exit |
| South end of freeway |
| 2.94 | 472A | Petaluma Boulevard South (US 101 Bus. north) | |
| Petaluma | 3.58 | 472B | SR 116 east – Sonoma, Napa | South end of SR 116 overlap |
| 4.76 | 474 | East Washington Street – Central Petaluma | |
| 5.76 | 476 | Old Redwood Highway, Petaluma Boulevard North (US 101 Bus. south) – Penngrove | |
| 10.67 | 479 | Railroad Avenue | Northbound exit and southbound entrance |
| Cotati | 12.00 | 481A | West Sierra Avenue – Cotati | Northbound exit and southbound entrance |
| 12.69 | 481B | SR 116 west (Gravenstein Highway) – Rohnert Park, Sebastopol, Cotati | North end of SR 116 overlap; signed as exit 481 southbound |
| Rohnert Park | 13.88 | 483 | Rohnert Park Expressway | |
| 15.02 | 484A | Golf Course Drive, Wilfred Avenue | Signed as exit 484 southbound |
| 15.53 | 484B | Santa Rosa Avenue (US 101 Bus. north) | Northbound exit and southbound entrance |
| 16.54 | 485 | Todd Road | |
| 18.49 | 487 | Yolanda Avenue, Hearn Avenue | |
| 19.00 | 488A | Baker Avenue, Santa Rosa Avenue, Corby Avenue | |
| Santa Rosa | 19.66 | 488B | SR 12 – Sebastopol, Sonoma | |
| 20.09 | 489 | Downtown Santa Rosa | |
| 20.74 | 490 | College Avenue | |
| 21.74 | 491A | Steele Lane, Guerneville Road | Signed as exit 491 southbound |
| 22.52 | 491B | Bicentennial Way | Northbound exit and southbound entrance |
| 22.81 | 492 | Hopper Avenue, Mendocino Avenue (US 101 Bus. south), Old Redwood Highway | |
| 24.86 | 494 | River Road – Guerneville, Calistoga | |
| 25.90 | 495A | Fulton Road – Fulton | |
| 26.33 | 495B | Airport Boulevard | |
| 27.62 | 496 | Shiloh Road | |
| 29.35 | 498 | Windsor | |
| 30.67 | 499 | Arata Lane | Northbound exit and southbound entrance |
| 33.48 | 502 | Healdsburg Avenue, Old Redwood Highway | |
| Healdsburg | 34.55 | 503 | Central Healdsburg | Northbound exit and southbound entrance |
| 34.88 | 504 | Westside Road – Guerneville | Southbound exit and northbound entrance |
| 36.27 | 505 | Dry Creek Road – Healdsburg | |
| R38.56 | 507 | Lytton Springs Road, Alexander Valley Road | |
| R40.03 | 509 | Independence Lane | |
| Geyserville | R41.43 | 510 | Geyserville Avenue to SR 128 east – Geyserville | |
| R43.37 | 512 | SR 128 east / Canyon Road (CR C1) – Geyserville, Calistoga | South end of SR 128 overlap |
| R47.85 | 517 | Asti | |
| R49.05 | 518 | Dutcher Creek Road – Stewarts Point | |
| R50.43 | 519 | South Cloverdale Boulevard (US 101 Bus. north, SR 128 Bus. west) | |
| Cloverdale | R51.62 | 520 | Citrus Fair Drive | |
| R53.40 | 522 | SR 128 west (US 101 Bus. south) – Fort Bragg, Mendocino | North end of SR 128 overlap |
Mendocino MEN R0.10-T106.80 | | 0.48 | 525 | Geysers Road | |
| North end of freeway |
| | | Old River Road | |
| Hopland | 10.89 | | SR 175 east – Lakeport | |
| South end of freeway |
| 19.68 | 544 | Burke Hill Drive | |
| 20.71 | 545 | Cox-Shrader Road | |
| R21.59 | 546 | SR 253 west – Ukiah, Boonville | |
| Ukiah | R23.45 | 548A | Talmage (SR 222) | |
| R24.06 | 548B | Gobbi Street | |
| R24.53 | 549 | Perkins Street, Vichy Springs Road – Central Ukiah | |
| R26.16 | 551 | North State Street – Ukiah | |
| 27.41 | 552 | Lake Mendocino Drive | |
| 30.43 | 555A | Calpella | |
| 30.83 | 555B | SR 20 east – Upper Lake, Williams | South end of SR 20 overlap |
| R32.63 | 557 | West Road | |
| North end of freeway |
| Willits | 46.36 | | SR 20 west (Fort Bragg Road) / Flower Street – Fort Bragg, Mendocino Coast | North end of SR 20 overlap |
| Longvale | 59.31 | | SR 162 east – Covelo, Round Valley | |
| Laytonville | 69.49 | | Branscomb, Dos Rios | |
| South end of freeway |
| R84.69 | 609 | SR 271 north | Former US 101 north |
| South Leggett | R89.57 | 614 | South Leggett (SR 271) | Former US 101 |
| North end of freeway |
| Leggett | T91.25 | | SR 1 south – Leggett, Fort Bragg | Former SR 208 south |
| South end of freeway |
| Reynolds | R101.89 | 625 | SR 271 | Former US 101 |
| Piercy | R103.81 | 627 | Piercy (SR 271) | Former US 101 |
Humboldt HUM T0.00-R137.44 | North end of freeway |
| Cooks Valley | T0.08 | | SR 271 south – Piercy, Cooks Valley | Former US 101 south |
| South end of freeway |
| Benbow | R8.60 | 636 | Benbow | |
| Garberville | R11.13 | 639A | Sprowel Creek Road (US 101 Bus. north) – Garberville | No northbound entrance |
| R11.50 | 639B | Garberville, Redway | No southbound entrance |
| R14.31 | 642 | Redwood Drive (US 101 Bus. south) – Redway | |
| R17.91 | 645 | Avenue of the Giants (SR 254), Hooker Creek Road – Phillipsville | |
| R22.44 | 650 | Miranda, Phillipsville | |
| 25.01 | 653 | Salmon Creek Road | |
| Myers Flat | 27.94 | 656 | Myers Flat (SR 254) | |
| 33.22 | 661 | Weott | |
| 35.70 | 663 | South Fork, Honeydew (SR 254) | |
| 39.16 | 667A | Avenue of the Giants (SR 254) | Southbound exit only |
| R39.67 | 667 | Redcrest, Holmes | |
| R43.32 | 671 | Pepperwood, Redcrest, Holmes | |
| R45.90 | 674 | Avenue of the Giants (SR 254), Jordan Road – Pepperwood | |
| R47.95 | 676 | Stafford Road | |
| Gap in freeway |
| R51.84 | 679 | Rio Dell, Scotia (SR 283, US 101 Bus. north) | |
| Rio Dell | R52.60 | 680 | Davis Street | |
| R53.38 | 681 | Wildwood Avenue (US 101 Bus. south) – Rio Dell | |
| North end of freeway |
| Alton | 57.69 | | SR 36 east – Hydesville, Bridgeville | |
| Rohnerville | 58.69 | | Drake Hill Road | |
| South end of freeway |
| Fortuna | 59.50 | 687 | Kenmar Road (US 101 Bus. north) – Fortuna | |
| 60.49 | 688 | 12th Street | |
| Fortuna | 61.53 | 689 | Main Street (US 101 Bus. south) | |
| 62.23 | 690 | Palmer Boulevard | |
| Fernbridge | 63.10 | 691 | Fernbridge, Ferndale (to SR 211) | Northbound exit and southbound entrance |
| 64.30 | 692 | Loleta, Fernbridge, Ferndale (SR 211) | |
| 65.95 | 694 | Loleta Drive | |
| 68.21 | 696 | Hookton Road – Loleta | |
| Eureka | 70.61 | 698 | College of the Redwoods | |
| 72.03 | 699 | Fields Landing | |
| 72.88 | 700 | King Salmon Avenue | |
| 73.72 | 701 | Humboldt Hill | |
| 74.77 | 702 | Herrick Avenue, Elk River Road | |
| North end of freeway |
| 79.17 | | SR 255 north (R Street) / Myrtle Avenue – Samoa | |
| | Jacobs Avenue | |
| 82.68 | | Indianola Cutoff | |
| Arcata | 83.92 | | Bayside Cutoff | |
| South end of freeway |
| 85.03 | 712 | South G Street | Southbound exit and entrance |
| 85.83 | 713 | SR 255 south (Samoa Boulevard) – Arcata, Samoa, Sunny Brae | |
| 86.50 | 714A | 14th Street – Humboldt State University | Northbound exit and southbound entrance |
| 86.94 | 714B | Sunset Avenue – Arcata, Humboldt State University | Signed as exit 714 southbound |
| 88.27 | 716A | SR 299 east – Weaverville, Redding | |
| 88.80 | 716B | Giuntoli Lane, Janes Road | |
| R90.13 | 718 | Central Avenue (US 101 Bus. north), North Bank Road (SR 200) – McKinleyville | |
| McKinleyville | R91.47 | 719 | School Road | |
| R93.00 | 721 | Murray Road | |
| R93.85 | 722 | Arcata-Eureka Airport | |
| R95.62 | 723 | North Central Avenue (US 101 Bus. south) – McKinleyville | |
| R97.02 | 725 | Crannell Road | |
| 98.07 | 726A | Westhaven Drive | Northbound exit and southbound entrance |
| 98.36 | 726B | 6th Avenue – Westhaven | Signed as exit 726 southbound |
| Trinidad | 100.71 | 728 | Trinidad | |
| R103.37 | 731 | Seawood Drive | |
| R106.06 | 734 | Patricks Point Drive | |
| North end of freeway |
| 122.25 | | Bald Hill Road – Lady Bird Johnson Grove | |
| South end of freeway |
| R126.09 | 753 | Newton B. Drury Scenic Parkway | Former US 101 north |
Del Norte DN M0.00-46.49 | | R0.15 | 765 | Newton B. Drury Scenic Parkway | Former US 101 south |
| R3.56 | 768 | Klamath Beach Road (CR D8) | |
| Klamath | R4.64 | 769 | SR 169 east – Klamath, Terwer Valley | |
| North end of freeway |
| Requa | 8.18 | | Minot Creek Road, Requa Road | |
| Crescent City | | | Elk Valley Road (CR D2), Huston Street | |
| 25.84 | | Elk Valley Road (CR D2) – Elk Valley Rancheria | |
| 27.01 | | CR D3 (Northcrest Drive) | |
| | | Parkway Drive to Washington Boulevard | Interchange; northbound exit and entrance |
| South end of freeway |
| R27.87 | 791 | Washington Boulevard (CR D1) | Southbound exit and northbound entrance |
| R30.81 | 794 |  US 199 north (Redwood Highway) to I-5 – Grants Pass | Northbound exit and southbound entrance |
| North end of freeway |
| 31.19 | | Elk Valley Cross Road to US 199 – Grants Pass | |
| | | Lake Earl Drive (CR D3) – Pelican Bay State Prison | |
| 36.26 | | SR 197 south (North Bank Road) | |
| Smith River | 39.83 | | Fred D. Haight Drive (CR D4) – Smith River | |
| | | Sarina Road, Ocean View Drive (CR D5) | |
| 46.49 | Oregon state line |