Tumor necrosis factor can refer to:

• Tumor necrosis factors, a class of cytokines
  • Tumor necrosis factor-alpha, the most frequently-mentioned member of this class, and what is referred to when the phrase "Tumor necrosis factor" is used without qualification
  • Tumor necrosis factor-beta, more commonly known as lymphotoxin.
• Tumour necrosis factor (album), the first studio album by Polish metal band Tumour of Soul released in the United States in March 2009

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