Tuftelin is an acidic phosphorylated glycoprotein found in tooth enamel. In humans, the Tuftelin protein is encoded by the TUFT1 gene.[1][2] [edit] Function This protein is formed for a short time during amelogenesis. The function of tuftelins is under contention, but it is proposed that it acts to start the mineralization process of enamel during tooth development.[3][4] Other significant proteins in enamel are amelogenins, enamelins, and ameloblastins. [edit] Research The human encoding gene for tuftelin (TUFT1) was cloned by Profs. Dany Deutsch and Aharon Palmon from the Hebrew University-Hadassah School of Dental Medicine in Jerusalem.[2] [edit] Interactions Tuftelin has been shown to interact with TFIP11.[5] [edit] References - ^ "Entrez Gene: TUFT1 tuftelin 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7286.
- ^ a b Deutsch D, Palmon A, Young MF, Selig S, Kearns WG, Fisher LW (July 1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization". Mamm. Genome 5 (7): 461–2. PMID 7919663.
- ^ Deutsch D (June 1989). "Structure and function of enamel gene products". Anat. Rec. 224 (2): 189–210. doi:10.1002/ar.1092240209. PMID 2672884.
- ^ Deutsch D, Palmon A, Fisher LW, Kolodny N, Termine JD, Young MF (August 1991). "Sequencing of bovine enamelin ("tuftelin") a novel acidic enamel protein". J. Biol. Chem. 266 (24): 16021–8. PMID 1874744. http://www.jbc.org/cgi/content/abstract/266/24/16021.
- ^ Paine, C T; Paine M L, Luo W, Okamoto C T, Lyngstadaas S P, Snead M L (Jul. 2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts". J. Biol. Chem. (UNITED STATES) 275 (29): 22284-92. doi:10.1074/jbc.M000118200. ISSN 0021-9258. PMID 10806191.
[edit] Further reading - Deutsch D, Leiser Y, Shay B, et al. (2003). "The human tuftelin gene and the expression of tuftelin in mineralizing and nonmineralizing tissues.". Connect. Tissue Res. 43 (2-3): 425–34. PMID 12489194.
- Deutsch D, Palmon A, Young MF, et al. (1994). "Mapping of the human tuftelin (TUFT1) gene to chromosome 1 by fluorescence in situ hybridization.". Mamm. Genome 5 (7): 461–2. PMID 7919663.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149.
- Paine CT, Paine ML, Luo W, et al. (2000). "A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts.". J. Biol. Chem. 275 (29): 22284–92. doi:10.1074/jbc.M000118200. PMID 10806191.
- Bashir MM, Abrams WR, Tucker T, et al. (2000). "Molecular cloning and characterization of the bovine and human tuftelin genes.". Connect. Tissue Res. 39 (1-3): 13–24; discussion 63–7. PMID 11062985.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
- Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing.". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMID 11256614.
- Mao Z, Shay B, Hekmati M, et al. (2002). "The human tuftelin gene: cloning and characterization.". Gene 279 (2): 181–96. PMID 11733143.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
- Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
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