Torasemide Information & Torasemide Links at HealthHaven.com

Torasemide
Systematic (IUPAC) name
	N-[(isopropylamino)carbonyl]-4-[(3-methylphenyl)amino]pyridine-3-sulfonamide
Identifiers
CAS number	56211-40-6
ATC code	C03CA04
PubChem	41781
DrugBank	APRD00217
Chemical data
Formula	C16H20N4O3S
Mol. mass	348.421 g/mol
SMILES	eMolecules & PubChem
Pharmacokinetic data
Bioavailability	80-90%
Protein binding	Highly bound (>99%).
Metabolism	Hepatic (80%)
Half life	3.5 hours; Cirrhosis: 7-8 hours
Excretion	?
Therapeutic considerations
Pregnancy cat.	C(US)
Legal status	℞-only(US)
Routes	Oral, IV ;

Torasemide (rINN) or torsemide (USAN) is a pyridine-sulfonyl urea type loop diuretic mainly used in the management of edema associated with congestive heart failure. It is also used at low doses for the management of hypertension. It is marketed under the brand name Demadex.

Compared to other loop diuretics, torasemide has a more prolonged diuretic effect than equipotent doses of furosemide and relatively decreased potassium-loss. There is no evidence of torasemide-induced ototoxicity demonstrated in humans ^[1].

[edit] References

^ Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs 49 (1): 121–42. PMID 7705212.

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[edit] External links

Medlineplus drug information: Torsemide (Systemic) – information from USP DI Advice for the Patient

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[0] Dunn CJ, Fitton A, Brogden RN (January 1995). "Torasemide. An update of its pharmacological properties and therapeutic efficacy". Drugs 49 (1): 121–42. PMID 7705212.

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