Tibotec is a pharmaceutical company with a focus on research and development for the treatment of infectious diseases such as HIV (AIDS), and Hepatitis C. The company develops antiretroviral drugs for the treatment of AIDS.

Contents 1 History 2 Drugs 3 See also 4 References 5 External links

[edit] History

In 1994, Rudi Pauwels (Rega Institute for Medical Research) founded Tibotec, together with his wife Carine Claeys, and their first co-workers Marie-Pierre de Béthune, Kurt Hertogs, and Hilde Azijn. In 1995 Paul Stoffels (Janssen Pharmaceutica) joined Tibotec. The company was acquired by Johnson & Johnson in April 2002. The name of the company is derived from the tetrahydro-imidazo[4,5,1-jk][1,4]-benzodiazepine-2(1H)-one and -thione (TIBO) compounds discovered at the Rega Institute for Medical Research (Belgium)^[1].

[edit] Drugs

• TMC114 (darunavir, tradename Prezista), a protease inhibitor (PI), (recently approved by the FDA)
• TMC125, (etravirine, tradename Intelence) a non-nucleoside reverse transcriptase inhibitor (NNRTI), (recently approved by the FDA)
• TMC207, an experimental diarylquinoline anti-tuberculosis drug^[2]
• TMC278, (rilpivirine) an NNRTI.

Tibotec licensed TMC120, an NNRTI, to the International Partnership for Microbicides for its development as a vaginal microbicide in March 2004.

[edit] See also

• Virco
• Galapagos Genomics
• Janssen Pharmaceutica
• FlandersBio

[edit] References

1. ^ Pauwels R, Andries K, Desmyter J, Schols D, Kukla MJ, Breslin HJ, Raeymaeckers A, Van Gelder J, Woestenborghs R, Heykants J, et al., Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives, Nature, 1990, 343, 470-474. doi:10.1038/343470a0
2. ^ Andries K, Verhasselt P, Guillemont J, et al. (2005), A diarylquinoline drug active on the ATP-synthase of Mycobacterium tuberculosis, Science 307 (5707): 223–27

[edit] External links

• Tibotec

v • d • e Johnson & Johnson William C. Weldon, Chairman & CEO Past CEOs and presidents: Robert Wood Johnson I • James Wood Johnson • Robert Wood Johnson II • Robert Wood Johnson III • Philip B. Hofmann • Richard B. Sellars • James E. Burke • Ralph S. Larsen Selected subsidiaries ALZA Corporation • Centocor • Cilag • DePuy, Inc. • Ethicon Endo-Surgery, Inc. • Ethicon, Inc. • Independence Technology, LLC • J&J PRD •Janssen Pharmaceutica • LifeScan • McNeil Consumer & Specialty Pharmaceuticals • Ortho-McNeil Pharmaceutical • Ortho-Neutrogena • Penaten • Tibotec Major brands Acuvue • Aveeno • Band-Aid • Carefree • Clean & Clear • Johnson's Baby • K-Y • Luden's • Neutrogena • OneTouch • Rembrandt • Stayfree • Tylenol Annual revenue: $63.75 billion USD ▲ 4.3% Annual net income: $12.95 billion USD ▲ 22.4% (FY 2008) · Employees: 118,700 · Stock symbol: NYSE: JNJ · Website: www.jnj.com

This article about a medical, pharmaceutical or biotechnological corporation or company is a stub. You can help Wikipedia by expanding it. v • d • e