Acetyl-Coenzyme A acetyltransferase Information & Acetyl-Coenzyme A acetyltransferase Links at HealthHaven.com

acetyl-Coenzyme A acetyltransferase 1 (acetoacetyl Coenzyme A thiolase)
Identifiers
Symbol	ACAT1
Alt. symbols	ACAT
Entrez	38
HUGO	93
OMIM	607809
RefSeq	NM_000019
UniProt	P24752
Other data
EC number	2.3.1.9
Locus	Chr. 11 q22.3-23.1

acetyl-Coenzyme A acetyltransferase 2 (acetoacetyl Coenzyme A thiolase)
Identifiers
Symbol	ACAT2
Entrez	39
HUGO	94
OMIM	100678
RefSeq	NM_005891
UniProt	Q9BWD1
Other data
EC number	2.3.1.9
Locus	Chr. 6 q25.3-q26

Acetyl-Coenzyme A acetyltransferase (or thiolase) is an enzyme which converts two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway.

Mevalonate pathway

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v • d • e Transferases: acyltransferases (EC 2.3)

2.3.1: other than amino-acyl groups (mostly acetyltransferases)	N-Acetylglutamate synthase - Choline acetyltransferase - Acetyl-Coenzyme A acetyltransferase - Dihydrolipoyl transacetylase - Acetyl-CoA C-acyltransferase - Beta-galactoside transacetylase - Carnitine O-palmitoyltransferase (CPT1, CPT2) - Acyltransferase like 2 - Chloramphenicol acetyltransferase - Aminolevulinic acid synthase - Beta-ketoacyl-ACP synthase - Glyceronephosphate O-acyltransferase - Lecithin-cholesterol acyltransferase - Histone acetyltransferase (P300/CBP) - Serotonin N-acetyl transferase - Serine C-palmitoyltransferase (SPTLC1, SPTLC2) - HGSNAT

2.3.2: Aminoacyltransferases	Gamma-glutamyl transpeptidase - Peptidyl transferase - Transglutaminase (Tissue transglutaminase, Keratinocyte transglutaminase, Factor XIII)

2.3.3: converted into alkyl on transfer	Citrate synthase - ATP citrate lyase - HMG-CoA synthase

To HMG-CoA	Acetyl-Coenzyme A acetyltransferase · HMG-CoA synthase (regulated step)

Ketogenesis	HMG-CoA lyase · 3-hydroxybutyrate dehydrogenase · Thiophorase

To Mevalonic acid	HMG-CoA reductase

To DMAPP	Mevalonate kinase · Phosphomevalonate kinase · Pyrophosphomevalonate decarboxylase · Isopentenyl-diphosphate delta isomerase

Geranyl-	Dimethylallyltranstransferase · Geranyl pyrophosphate

To lanosterol	Farnesyl-diphosphate farnesyltransferase · Squalene monooxygenase · Lanosterol synthase

7-Dehydrocholesterol path	Lanosterol 14α-demethylase · Sterol-C5-desaturase-like · 7-Dehydrocholesterol reductase

Desmosterol path	24-dehydrocholesterol reductase