| Theaflavin digallate |  | | IUPAC name | [1-[(2R,3R)-3,5-dihydroxy-7-(3,4,5-trihydroxybenzoyl)oxychroman-2-yl]-3,5-dihydroxy-6-oxo-8-[(3R)-3,5,7-trihydroxychroman-2-yl]benzo[7]annulen-4-yl] 3,4,5-trihydroxybenzoate | | Identifiers | | CAS number | 33377-72-9 | | PubChem | 5748168 | | SMILES | C1[C@H](C(OC2=CC(=CC(=C21)O)O)C3=CC(=O)C(=C4C(=C3)C(=CC(=C4OC(=O)C5=CC(=C(C(=C5)O)O)O)O)[C@@H]6[C@@H](CC7=C(C=C(C=C7O6)OC(=O)C8=CC(=C(C(=C8)O)O)O)O)O)O)O | | Properties | | Molecular formula | C43H32O20 | | Molar mass | 868.702 | | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) | | Infobox references | Theaflavin digallate (also TFDG, TF-3, Theaflavin-3,3'-digallate) is a antioxidantpolyphenol found in black tea, and a theaflavin derivative. [edit] Health - TF-3 is a potent scavenger of superoxide, even more so than EGCG.[1]
- Tea polyphenols including theaflavin TFDG are found to reduce angiogenesis[2], which is implicated in non-liquid cancers, an area of intense current research, by decreasing vascular endothelial growth factor production and receptor phosphorylation.
- Epigallocatechin gallate (EGCG), a catechin in green tea, binds to gp120, which works in conjunction with gp41, itself blocked by TF-3, both receptors of which HIV hijacks to enter into healthy human immune cells. Therefore, former and latter compounds have considerable potential to block HIV entry, though in real life situations other factors may complicate matters. More studies need to be done. as well as inhibit 3CLPro of severe acute respiratory syndrome (SARS).[3]
- TFDG also inhibits 3CLPro of severe acute respiratory syndrome (SARS).[3]
[edit] See also [edit] References |
