Tetrahydrocannabivarin Information & Tetrahydrocannabivarin Links at HealthHaven.com

Tetrahydrocannabivarin
IUPAC name	6,6,9-trimethyl-3-propyl-6a,7,8,10a- tetrahydrobenzo[c]chromen-1-ol
Other names	Tetrahydrocannabivarol
Identifiers
CAS number	28172-17-0
PubChem	34180
SMILES	CCCC1=CC2=C(C3C=C(CCC3C(O2)(C)C)C)C(=C1)O
ChemSpider ID	31500
Properties
Molecular formula	C19H26O2
Molar mass	286.41
	Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references

Tetrahydrocannabivarin (THCV, THV), also known as tetrahydrocannabivarol, is a psychoactive cannabinoid found naturally in Cannabis sativa. It is an analogue of tetrahydrocannabinol (THC) with the sidechain shortened by two CH₂ groups. THCV can be used as a marker compound to differentiate between the consumption of hemp products and synthetic THC (e.g., Marinol).

[edit] Natural occurrence

THCV is found in largest quantities in Cannabis sativa subsp. indica strains. Some varieties that produce propyl cannabinoids in significant amounts, over five percent of total cannabinoids, have been found in plants from South Africa, Nigeria, Afghanistan, India, Pakistan and Nepal with THCV as high as 53.69% of total cannabinoids.^[1] They usually have moderate to high levels of both THC and Cannabidiol (CBD) and hence have a complex cannabinoid chemistry representing some of the world's most exotic cannabis varieties.^[2]

[edit] Pharmaceutical properties

It has been shown to be a CB₁ receptor antagonist, i.e. blocks the effects of THC.^[3] In 2007 GW Pharmaceuticals announced that THCV is safe in humans in a clinical trial and it will continue to develop THCV as a potential cannabinoid treatment for type 2 diabetes and related metabolic disorders, similar to the CB₁ receptor antagonist rimonabant.^[4]

[edit] See also

Cannabinoids
Cannabis
Medical marijuana
Rimonabant (synthetic CB1 antagonist)

[edit] References

^ Turner, C.E., Hadley, K.W., and Fetterman, P. 1973. Constituents of Cannabis Sativa L., VI: Propyl Homologues in Samples of Known Geographical Origin. J. Pharm. Sci. 62(10):1739-1741
^ Deluxe Marijuana Grower's Guide, by Mel Frank [revised edition 1997] pg.37
^ Pertwee RG, Thomas A, Stevenson LA, et al. (2007). "The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo". Br. J. Pharmacol. 150 (5): 586–94. doi:10.1038/sj.bjp.0707124. PMID 17245367.
^ Press Release by GW Pharmaceuticals[1]

[edit] External links

Erowid Compounds found in Cannabis sativa
www.tetrahydrocannabivarin.com Article on THCV

This article about a cannabinoid is a stub. You can help Wikipedia by expanding it.

[0] Turner, C.E., Hadley, K.W., and Fetterman, P. 1973. Constituents of Cannabis Sativa L., VI: Propyl Homologues in Samples of Known Geographical Origin. J. Pharm. Sci. 62(10):1739-1741

[1] Deluxe Marijuana Grower's Guide, by Mel Frank [revised edition 1997] pg.37

[2] Pertwee RG, Thomas A, Stevenson LA, et al. (2007). "The psychoactive plant cannabinoid, Delta9-tetrahydrocannabinol, is antagonized by Delta8- and Delta9-tetrahydrocannabivarin in mice in vivo". Br. J. Pharmacol. 150 (5): 586–94. doi:10.1038/sj.bjp.0707124. PMID 17245367.

[3] Press Release by GW Pharmaceuticals[1]

[1]

[2]

[3]

[4]

Contents

[edit] Natural occurrence

[edit] Pharmaceutical properties

[edit] See also

[edit] References

[edit] External links