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Inhibition of tumor cell invasion and ErbB2/PI3K signaling pathways by the glutathione disulfide-mimetic NOV-002

K.Gumireddy1, C.Pazoles2

E.Vulfson2, and Q.Huang1

1The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104;

2Novelos Therapeutics, Inc., One Gateway Center, Newton, MA 02458

• Protein glutathionylation by NOV-002 results in pleiotropic effects on cell functions including cell signaling pathways, cytoskeletal architecture and cytokine production and is associated with hematopoiesis, immune stimulation and increased chemosensitivity of tumor cells.

References

Townsend, DM et al. Cancer Res 2008; 68 (8): 2870-2877.

Townsend, DM et al. Exp Opin Invest Drugs 2008; 17 (7): 1075-1083

Krasner, CN et al. J Clin Oncol 26: 2008 (May 20 suppl; abstr 5593)

Bixbyte (talk) 20:57, 12 October 2009 (UTC)Bixbyte