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Tardive Psychosis is a form of psychosis distinct from schizophrenia and induced by the use of current (dopaminergic) antipsychotics by the depletion of dopamine and related to the known side-effect caused by their long term use, tardive dyskinesia.

In addition to dopaminergic upregulation in the nigrostriatal tracts, many investigators have suggested that dopaminergic upregulation may occur in mesolimbic or mesocortical tracts, leading to a worsening of psychosis beyond the original level. This phenomenon has been called tardive psychosis' or 'supersensitivity psychosis 'Clozaril and typical antipsychotics' ^[1]

Tardive psychosis was researched in 1978 and 1989 and sporadic research continues. Some studies have found it to be associated with psychotic depression and potentially dissociation. For people with any tardive conditions Clozapine remains an option but in creating blood dyscrasias which require frequent blood work as well as other severe side effects, it is used increasingly less in clinical practice. Although tardive psychosis continues to be studied, it still has not been established as a fact but it is known that the study classes of antipsychotics such as the NMDA Receptor Modulators (glutamate antagonists) in not creating tardive dyskinesia will not create this condition. Although tardive psychosis and the little understood hypothetical condition tardive dysmentia have been used as reasons for the anti-psychiatry movement that antipsychotics are too dangerous to use in clinical practice, they are actually potential reasons for the continued research and realization of new antipsychotics in development that cannot create them. As well experimental treatments for tardive dyskinesia such as Ondansetron are being used to treat psychosis from Parkinsons' Disease and tardive dyskinesia as well as the natural remedy rhodiola which is being researched for Parkinson's Disease as well as tardive dyskinesia (Dr. Richard Brown, M.D., Susan Gerbarg, M.D. "The Rhodiola Revolution") and are tentatively showing to be of use in this condition.

[edit] References

1. ^ David E. Ross M.D. American Journal of Psychiatry, 161:1925-1926, October 2004

• http://ajp.psychiatryonline.org/cgi/content/full/161/10/1925-a

http://www.haveahealthymind.com/rhodioloa-revolution.html