WikiProject Medicine / Dermatology	(Rated Stub-Class, Mid-importance)	MedicineWikipedia:WikiProject MedicineTemplate:WPMEDmedicine articles
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[edit] Article categorization

This article was categorized based on scheme outlined at WP:DERM:CAT. kilbad (talk) 00:43, 13 January 2009 (UTC)

[edit] Other comments

this article should be translated from the corresponding articles - german or spanish - they contain much more scientific information!

Actually, this article is wrong. Think about it. If keratinocytes made a chemical upon DNA destruction called "thymidine dinucleotide" which caused the pituitary gland to make a hormone which triggers melanocytes to make melanosomes, releasing them along dendrites where they go to the top layer of the skin... What would stop the hormone from triggering an even tan? Nothing. There's something missing from the equation as it were. Otherwise, tan lines would not exist. And they do!

You see:

"Nitric Oxide and cGMP production is required for UVB-induced melanogenesis and that cGMP mediated its melanogenic effects mainly through the activation of cGMP-dependent kinase. " is how a tan is made. In laymen's terms what effectively happens is that UV-B triggers NO production which in turn triggers cGMP production which triggers melanocytes to undergo melanogenesis.--I'll bring the food 07:01, 2 January 2007 (UTC)

I partiallly fixed it, but it requires much work, I don't have the time either, what a shame.--I'll bring the food 07:46, 2 January 2007 (UTC)

My understanding was the the melanocortins are also produced in both a paracrine and autocrine manner (by keratinocytes and melanocytes respectively) in response to UV. This would explain tan lines. Rockpocket 08:20, 2 January 2007 (UTC)

Thank you for your contribution to this discussion. If you have a source for that I'll add it to the article. As it is, more will need to be made of the "melanocortins" term in it.--I'll bring the food (Talk - Contribs - My Watchlist) 13:47, 6 January 2007 (UTC)

someone should summerize this bcl 2 gene deal: http://www.sunherald.com/160/story/399028.html —Preceding unsigned comment added by Jaanussilla (talk • contribs) 15:09, 7 March 2008 (UTC)