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MCB portal v • d • e This article is within the scope of the Molecular and Cellular Biology WikiProject. To participate, visit the WikiProject for more information. The WikiProject's current monthly collaboration is focused on improving Gene expression.  B  This article has been rated as B-Class on the project's quality scale.  Top  This article has been rated as Top-importance on the project's importance scale.

This article was the MCB Collaboration of the Month for the month of August 2007. For more details, see the MCB Collaboration of the Month history.

edit · history · watch · refresh  To-do list for Cell cycle:

Here are some tasks you can do: Add more references Convert textbook references to inline references Expand Regulation of cell cycle section - Expanded. Expand Checkpoints section - Ok, probably not necessary as there is Cell cycle checkpoint already Improve upon / possibly rewrite the lead paragraph - Improved. More work probably needed. Add diagram(s) to elucidate regulation of cell cycle - Added Image:Regulation of cell cycle.png. Could be improved. Add section Cell cycle and tumor production - Added section Role of cell cycle in tumor formation; more work needed.

It is requested that a diagram or diagrams be included in this article to improve its quality. For more information, refer to discussion on this page and/or the listing at Wikipedia:Requested images.

[edit] Article's quality

Does it describe Eukaryotic cells or all cells ? Do all cells folow this cycle or are there some exceptions ? -- Taw

I think this is specific only to eucaryotes, but among these, the mechanism is fairly conserved from yeast to man. AttishOculus 22:19, 11 Jun 2005 (UTC)

Is there a reason to have this article separate from Cell division and Mitosis - Marshman 05:46, 30 Sep 2003 (UTC)

Yes. Mitosis is only one small part of the cell cycle. There is more than enough information about mitosis to justify its having its own entry, but it should not be combined with cell cycle. ~mdash; Brim 17:38, Nov 27, 2004 (UTC)

I think this topic would deserve some additional, more detailed information. (exeact transitions, checkpoints, cyclins, CDK's and CKI's in detail etc.) I would be glad to add some more information, regarding the importance of the subject (in cancer research, for example), but as I am only a I could use no other source of knowledge but my textbooks, so I would be happy to have an expert look through my work every once in a while.

Additionally, I fear that stacking up the article with scientific info would make the whole article frightening and overwhelming for non-professionals. What would you recommend in order to avoid that? Would having separate sections in the article after the current one as an introduction be sufficient, or would it be better to add a new article "Cell cycle in detail", or just have a number of new pages linked into the main page (eg. "Replication initiation mechanisms")? What would be the general Wikipedia practice in such cases? AttishOculus 22:19, 11 Jun 2005 (UTC)

This article lacks so much info...i mean a lot. I came here looking for help on the topic--because i just couldn't understand some of it, and it wasn't here. All of the stages require info of the cell cycle. The Mitosis part deserves its own part. The cycle's checking system needs its own part. This is one bad article. I'll try to fix it in a day or two after my test. :) Nominaladversary 01:54, 31 March 2006 (UTC)

The mitosis part has its own part at mitosis. I'd bet my boots check points will also direct you to the cycle's checking system too. Aaadddaaammm 07:10, 19 October 2006 (UTC)

[edit] No description of basic process of cell division

There has to be a section dvoted to description of all phases during mitosis (and variations during a meiosis). The article seems to dwell heavily upon recent advances in molecular biology. These advances have to be placed in perspective with the general biology of the cell cycle Nattu 20:21, 16 June 2006 (UTC)

This article is a recent retooling of a rather poor, stubby original. Currently mitosis and meiosis have their own articles, which are in a much better state than this one was; the phases of mitosis also have their own articles. There's an emphasis on molecular biology in the current article because I wrote it :) Feel free to add more general information, as I think in time this article should evolve to be a proper header for Category:Cell cycle.

Yes, the mol bio part is good and we can shape it further. For now, emphasis must be on cell cycle basics and I will contribute my bit to it. Nattu 19:19, 23 June 2006 (UTC)

[edit] Image issues

The current illustration of the cell cycle should be removed or replaced in my opinion. It would almost have been ok if all the phases seemed to have equal duration. But in this illustration S phase is actually smaller than the G2 phase! - HungryHippo 19. july 2006

You're right, it's not really very good, but I do think it's better than nothing (especially given the explanation of its deficiencies in the caption). I've posted a {{reqdiagram}} in the hopes of attracting a good diagram creator, which I am not. Opabinia regalis 02:07, 20 July 2006 (UTC)

The second diagram on this page is horrificly inaccurate. How it can center around CDK2 when it has been shown that this is redundant to CDK1?

Berthet, C., E. Aleem, V. Coppola, L. Tessarollo, and P. Kaldis. 2003. Cdk2 knockout mice are viable. Curr. Biol. 13:1775–1785.

The Journal of Cell Biology, Vol. 178, No. 2, July 16, 2007 257–268

Please consider revision of this image! —Preceding unsigned comment added by 129.31.120.113 (talk) 11:34, 8 July 2009 (UTC)

[edit] About diploid, haploid and monoploid

"In this quantity of DNA within the cell has increased to 4c, but the cell is still considered diploid." Finally i got the information.

[edit] embryology

Does anyone happen to know any embryologists? I think Embryology really needs a lot of expert attention. would sympathtic editors consider a positive vote here? [1]Slrubenstein | Talk 19:05, 28 August 2006 (UTC)

[edit] Mitosis vs. M phase

As far as I know M phase=Mitosis+Cytokinesis, but there is no article on M phase, only on Mitosis, and in the picture:

Schematic of the cell cycle. I=Interphase, M=Mitosis. The duration of mitosis in relation to the other phases has
been exaggerated in this diagram

, I think, M phase is denoted by letter "M" and not Mitosis, as there are four phases: G1, S, G2 and M (+G0). Should the text below the picture be changed?

Andrius 14:49, 29 October 2006 (UTC)

[edit] About the diagram

I can make a fairly good diagram, but I am not an exepert on cellulear procesess, so e-mail me with even a napkin drawing of the correct process and I'll "pimp it out". thanks

Yupi666 20:15, 14 June 2007 (UTC)

[edit] Copyedit and minor expansion

I have done some minor expansion and copy-editing and fixed some formatting issues. I will be adding some references in the coming one or two days. Please comment here if there are any errors or omissions. Also, I think it would be better if we do away with the Observation and Research Groups sections. Also, Regulation of cell cycle can be greatly expanded. Or can be made into a totally separate article. Any comments? - TwoOars 10:46, 1 August 2007 (UTC)

[edit] References

Added a few references. Am removing the "refs needed" tag. I do not know how to add inline refs though, for the rest of the stuff - I mean the basic stuff about the phases, which is found in any basic textbook. Am assuming inline refs are not needed in such cases. - TwoOars 19:23, 1 August 2007 (UTC)

[edit] The template

As an aside, how about adding links to the checkpoints from {{Cell cycle}}? Please comment at Template talk:Cell cycle. Thanks. - TwoOars 18:20, 3 August 2007 (UTC)

Never mind. Has been taken care of by Arcadian. - TwoOars 17:07, 4 August 2007 (UTC)

Nobody should be an aside in Wikipedia - feel as free to edit as anybody! Mikael Häggström 16:30, 5 August 2007 (UTC)

[edit] Another problem with the diagram

The Yellow "M" should not refer to Metaphase but to mitosis again. The counterpart of interphase is not the metaphase but the mitosis which include prophase, metaphase, anaphase and telophase.—Preceding unsigned comment added by Vardos (talk • contribs)

You are right. I changed it. I don't know how we missed it all this while, that too after a monthly collaboration. :P - TwoOars (Rev) 16:03, 7 October 2007 (UTC)

[edit] Why only eukaryotes?

The term Cell Cycle can apply to both prokaryotes and eukarotes, but the article focuses entirely on eukaryotes. In my opinion the article can be strengthened with an additional prokaryote section....or at the minimum, include some sort of reference to prokaryotes. --Naturespace (talk) 04:56, 5 December 2008 (UTC)

[edit] Quality

i would just like to note that my grade 9 science textbook has better descriptions on what actually happens in cell division and if i remember correctly there are alot more phases than the 4 mentioned.... Walkerm930 (talk) 19:40, 27 March 2009 (UTC)

I think the confusion here is that you may have been looking for the mitosis or cell division article(s) and not cell cycle. The treatment of the cell cycle in high school biology books, if it is mentioned at all, is very brief. Mitosis in contrast is treated in some depth. The mitosis stage of the cell cycle involves the physical separation of the duplicated chromosomes during cell division and is divided into prophase/prometaphase/metaphase/anaphase/telophase substages (see the diagram below the Mitosis#Preprophase section). The cell cycle, in addition to the mitosis step, involves growth of the cell and molecular replication of DNA. Cheers. Boghog2 (talk) 07:06, 28 March 2009 (UTC)

I have just added the following to the top of this article:

This page is about cellular growth, DNA replication and division. For separation of chromosomes, see mitosis.

I hope this reduces the confusion. Boghog2 (talk) 20:35, 7 April 2009 (UTC)

Or even more to the point:

For the separation of chromosomes that occurs as part of the cell cycle, see mitosis.

Boghog2 (talk) 05:10, 8 April 2009 (UTC)

[edit] cell cycle

is a function of life and how that it wordks —Preceding unsigned comment added by 170.211.230.126 (talk) 14:20, 1 October 2009 (UTC)