 |
| Tacalcitol |
| Systematic (IUPAC) name |
| (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol |
| Identifiers |
| CAS number | 57333-96-7 |
| ATC code | D05AX04 |
| PubChem | 5283734 |
| Chemical data |
| Formula | C27H44O3 |
| Mol. mass | 416.64 |
| Synonyms | (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(2R,5R)-5-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol |
| Pharmacokinetic data |
| Bioavailability | ? |
| Metabolism | ? |
| Half life | ? |
| Excretion | ? |
| Therapeutic considerations |
| Pregnancy cat. | ? |
| Legal status | |
| Routes | Topical
|
Tacalcitol is a synthetic vitamin D3 analogue.[1]
Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.
[edit] Mechanism
Tacalcitol exerts its biological activity by preventing the proliferation of keratinocytes.
It is used to treat psoriasis.
It has been used for vitiligo[2] and Hailey-Hailey disease.[3]
[edit] References
- ^ Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). "Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes". Skin Pharmacol. Appl. Skin Physiol. 14 (4): 226–33. PMID 11464105. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=sph14226.
- ^ Leone G, Pacifico A, Iacovelli P, Paro Vidolin A, Picardo M (March 2006). "Tacalcitol and narrow-band phototherapy in patients with vitiligo". Clin. Exp. Dermatol. 31 (2): 200–5. doi:10.1111/j.1365-2230.2005.02037.x. PMID 16487090. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0307-6938&date=2006&volume=31&issue=2&spage=200.
- ^ Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S (November 1998). "1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro". Br. J. Dermatol. 139 (5): 897–901. PMID 9892963. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0007-0963&date=1998&volume=139&issue=5&spage=897.
