Systemic refers to something that is spread throughout, system-wide, affecting a group or system such as a body, economy, market or society as a whole. It should not be confused with "systematic", which means methodical. Systemic may also refer to:
- Systemic disease, an illness that affects multiple organs, systems or tissues, or the entire body
- Systemic bias, the inherent tendency of a process to favor particular outcomes
- Systemic circulation, carries oxygenated blood from the heart to the body and then returns deoxygenated blood back to the heart
- Systemic venous system, refers to veins that drain into the right atrium without passing through two vascular beds
- Systemic lupus erythematosus, a chronic autoimmune connective tissue disease that can affect any part of the body
- Systemic inflammatory response syndrome, an inflammatory state affecting the whole body, frequently in response to infection
- Systemic scleroderma, also known as systemic sclerosis, a systemic connective tissue disease
- Systemic acquired resistance, a "whole-plant" resistance response that occurs following an earlier localized exposure to a pathogen
- Systemic pesticide, a pesticide that affects multiple organs or critical functions of the target species
- Systemic (amateur extrasolar planet search project), a research project to locate extrasolar planets using distributed computing
- Systemic linguistics, an approach to linguistics that considers language as a system
- Systemic functional grammar, also called systemic functional linguistics, a model of grammar that considers language as a system
- Systemic risk, the risk of collapse of an entire financial system or market, as opposed to risk associated with any one entity
- Systemic shock, a shock to any system strong enough to drive it out of equilibrium, can refer to a change in many fields
- Systemic therapy, a school of psychology dealing with the interactions of groups and their interactional patterns and dynamics
- Systems psychology, also called systemic psychology, a branch of applied psychology based on systems theory and thinking
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