Strabismus (protein) Information & Strabismus (protein) Links at HealthHaven.com

For other uses, see Strabismus (disambiguation).

vang-like 1 (van gogh, Drosophila)
Identifiers
Symbol(s)	VANGL1
Entrez	81839
OMIM	610132

Strabismus was originally identified as a Drosophila protein involved in planar cell polarity ^[1]. Flies with mutated stranismus genes have altered development of omatidia in their eyes. Vertebrates have two Strabismus-related proteins, VANGL1 and VANGL2 (an alternate name for the Drosophila "Strabismus" protein is "Van Gogh").

The amino acid sequence and localization studies for Strabismus indicate that it is a membrane protein. Prickle is another protein in the planar cell polarity signaling pathway. Prickle is recruited to the cell surface membrane by strabismus^[2]. In cells of the developing Drosophila wing, Prickle and Strabismus are concentrated at the cell surface membrane on the most proximal side of cells^[3].

[edit] Vertebrate cell movement

vang-like 2 (van gogh, Drosophila)
Identifiers
Symbol(s)	VANGL2
Entrez	57216
OMIM	600533

VANGL2 is involved in the migration of groups of cells during vertebrate embryogenesis^[4].

[edit] Humans

In humans, mutations in VANGL1 have been associated with neural tube defects including spina bifida,^[5] and with some forms of cancer including hepatocellular carcinoma.^[6]^[7]

[edit] References

^ Tanya Wolff and Gerald M. Rubin (1998) "Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila" in Development Volume 125, pages 1149-1159. Entrez Pubmed 9463361
^ R. Bastock, H. Strutt and D. Strutt (2003) "Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning" in Development Volume 130, pages 3007-3014. Entrez Pubmed 12756182
^ M. Fanto and H. McNeill (2004) "Planar polarity from flies to vertebrates" in Journal of Cell Science Volume 117, pages 527-533. Entrez Pubmed 14730010
^ Rachel S. Darken, Adriane M. Scola, Andrew S. Rakeman, Gishnu Das, Marek Mlodzik and Paul A. Wilson (2002) "The planar polarity gene strabismus regulates convergent extension movements in Xenopus" in EMBO Journal Volume 21, pages 976-985. Entrez Pubmed 11867525
^ Kibar Z, Torban E, McDearmid JR, Reynolds A, Berghout J, Mathieu M, Kirillova I, De Marco P, Merello E, Hayes JM, Wallingford JB, Drapeau P, Capra V, Gros P (2007). "Mutations in VANGL1 associated with neural-tube defects." (^{[dead link]} – ^{Scholar search}). N. Engl. J. Med. 356 (14): 1432–7. doi:10.1056/NEJMoa060651. PMID 17409324. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=17409324&promo=ONFLNS19.
^ Yagyu R, Hamamoto R, Furukawa Y, Okabe H, Yamamura T, Nakamura Y (2002). "Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma.". Int. J. Oncol. 20 (6): 1173–8. PMID 12011995.
^ Katoh M (2002). "Strabismus (STB)/Vang-like (VANGL) gene family (Review).". Int. J. Mol. Med. 10 (1): 11–5. PMID 12060845.

[0] Tanya Wolff and Gerald M. Rubin (1998) "Strabismus, a novel gene that regulates tissue polarity and cell fate decisions in Drosophila" in Development Volume 125, pages 1149-1159. Entrez Pubmed 9463361

[Bastock-1] R. Bastock, H. Strutt and D. Strutt (2003) "Strabismus is asymmetrically localised and binds to Prickle and Dishevelled during Drosophila planar polarity patterning" in Development Volume 130, pages 3007-3014. Entrez Pubmed 12756182

[Fanto-2] M. Fanto and H. McNeill (2004) "Planar polarity from flies to vertebrates" in Journal of Cell Science Volume 117, pages 527-533. Entrez Pubmed 14730010

[3] Rachel S. Darken, Adriane M. Scola, Andrew S. Rakeman, Gishnu Das, Marek Mlodzik and Paul A. Wilson (2002) "The planar polarity gene strabismus regulates convergent extension movements in Xenopus" in EMBO Journal Volume 21, pages 976-985. Entrez Pubmed 11867525

[pmid17409324-4] Kibar Z, Torban E, McDearmid JR, Reynolds A, Berghout J, Mathieu M, Kirillova I, De Marco P, Merello E, Hayes JM, Wallingford JB, Drapeau P, Capra V, Gros P (2007). "Mutations in VANGL1 associated with neural-tube defects." (^{[dead link]} – ^{Scholar search}). N. Engl. J. Med. 356 (14): 1432–7. doi:10.1056/NEJMoa060651. PMID 17409324. http://content.nejm.org/cgi/pmidlookup?view=short&pmid=17409324&promo=ONFLNS19.

[pmid12011995-5] Yagyu R, Hamamoto R, Furukawa Y, Okabe H, Yamamura T, Nakamura Y (2002). "Isolation and characterization of a novel human gene, VANGL1, as a therapeutic target for hepatocellular carcinoma.". Int. J. Oncol. 20 (6): 1173–8. PMID 12011995.

[pmid12060845-6] Katoh M (2002). "Strabismus (STB)/Vang-like (VANGL) gene family (Review).". Int. J. Mol. Med. 10 (1): 11–5. PMID 12060845.

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