Steven A. Garan is currently a research scientist at the Lawrence Berkeley National Laboratory. While at the University of California, Berkeley, he played a major role in the invention and the development of the Automated Imaging Microscope System (AIMS). While at UC Berkeley, Garan collaborated for many years with a group from Paola S. Timiras's lab, on the role that caloric restriction plays in maintaining estrogen receptor-alpha and IGH-1 receptor immunoreactivity in various nuclei of the mouse hypothalamus. Garan was also the director of the Aging Research Centre, and is a leading scientist in the field of aging research. His numerous publications, include articles on systems biology, the effects of caloric restriction on the mouse hypothalamus and on the Automated Imaging Microscope System (AIMS). He is best known for the coining of word "Phenomics", which was defined in an abstract titled: "Phenomics: a new direction for the study of neuroendocrine aging", that was published in the journal Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 218.

[edit] Publications

• "The plasticity of neural cell reprogramming: Role of growth factors in inducing neuroglia to neuron and to neural precursor cell". A.M. Gouw, K. Mahuron, S. Manandhar, A. Tin, S.A. Garan, P. Hakimi, P.S. Timiras; Experimental Gerontology", Volume 44, Issues 1-2, January-February 2009, Page 129

• "Shortest path algorithms combined with natural language parsing, map pathways involved in neuroendocrine aging". S.A. Garan, W. Freitag, A.M. Gouw, B. Rizvi, S. Prashad, V. Csapo; Experimental Gerontology", Volume 44, Issues 1-2, January-February 2009, Page 129

• "The Potential Role of Epidermal Growth Factor (EGF) and Curcumin in Transforming Neuroglia into Neurons". AM Gouw, H Panchal, K Mahuron, H Wadhwani, S Manandhar, SA Garan, A Tin, PS Timiras; Endocrine Society's 90th Conference Proceedings, June 2008, Page 364

• "A computational systems biology approach to neuroendocrine aging: Initial results". S.A. Garan, W. Freitag, V. Csapo, P. Chrysler, B. Rizvi and N. Shewaramani; Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Page 142

• "Novel methods in computer-assisted tissue analysis: Customized regional targeting of both cytoplasmic and nuclear-stained tissue". S.A. Garan, F. Yaghmaie, O. Saeed, A.M. Gouw, W. Freitag, M.A. Voelker, P. Jafar, J. Kaur and S. Nijjar; Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 141-142

• "Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice". Yaghmaie F, Saeed O, Garan SA, Voelker MA, Gouw AM, Freitag W, Sternberg H, Timiras PS.; Neurology & Neurosurgery, Para. 488, Page 99, Sec. 8, Vol 152.2, 2007

• "Tracking changes in hypothalamic IGF-1 sensitivity with aging and caloric restriction". F. Yaghmaie, O. Saeed, S.A. Garan, A.M. Gouw, P. Jafar, J. Kaur, S. Nijjar, P.S. Timiras, H. Sternberg and M.A. Voelker; Experimental Gerontology, Volume 42, Issues 1-2 , January-February 2007, Pages 11-12.

• "Insulin-like growth factor-1 receptor immunoreactive cells are selectively maintained in the paraventricular hypothalamus of calorically restricted mice". Saeed O, Yaghmaie F, Garan SA, Gouw AM, Voelker MA, Sternberg H, Timiras PS.; Int J Dev Neurosci. 2007 Feb;25(1):23-8

• "Age-dependent loss of insulin-like growth factor-1 receptor immunoreactive cells in the supraoptic hypothalamus is reduced in calorically restricted mice". Yaghmaie F, Saeed O, Garan SA, Voelker MA, Gouw AM, Freitag W, Sternberg H, Timiras PS.; Int J Dev Neurosci. 2006 Nov;24(7):431-6.

• "A study of insulin-like growth factor-I receptor immunoreactivity in the supraoptic nucleus of young and old female B6D2F1 mice". Farzin Yaghmaie, Omar Saeed, Steven A. Garan, Arvin M. Gouw, Tien Tran, Jacqueline Ho, Liu Y. Zhao, Mark A. Voelker and Paola S. Timiras; FASEB Journal, April 2006, 357.5

• "Caloric restriction reduces cell loss and maintains estrogen receptor-alpha immunoreactivity in the pre-optic hypothalamus of female B6D2F1 mice". Yaghmaie F, Saeed O, Garan SA, Freitag W, Timiras PS, Sternberg H.; Neuro Endocrinol Lett. 2005 June;26(3):197-203.

• "A survey of estrogen receptor-alpha immunoreactivity in the hypothalamus of young, old, and old-calorie restricted female B6D2F1 mice", F. Yaghmaie, S.A. Garan, O. Saeed, W. Freitag, P.S. Timiras, H. Sternberg, M. Voelker; Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1771

• "Protocol for higher resolution histological images of the mammalian brain", M. Voelker, F. Yaghmaie, S.A. Garan H. Sternberg,; Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1770

• "Towards a self-learning, self-assembling systemic map of neuroendocrine aging", S.A. Garan, W. Freitag, F. Yaghmaie, B. Oster, P. Chrysler, R. Bacinello, K. Honeyford, P. Yaghmaie, M. Voelker, P.S. Timiras; Experimental Gerontology, Volume 39, Issues 11-12, November-December 2004, Page 1767

• "Phenomics: a new direction for the study of neuroendocrine aging". S.A. Garan, W. Freitag, F. Yaghmaie, B. Oster, P.S. Timiras; Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 218

• "A comparison of estrogen receptor-alpha immunoreactivity in the arcuate hypothalamus of young and middle-aged C57BL6 female mice". Yaghmaie F, Garan SA, Massaro M, Timiras PS; Experimental Gerontology, Volume 38 (2003), Issues 1-2, Page 220

• "Creating Three-Dimensional Neuronal Maps of the Mouse Hypothalamus Using an Automated Imaging Microscope System". Garan SA, Neudorf J, Tonkin J, McCook LR, Timiras PS.; Experimental Gerontology, Volume 35 numbers 9-10, December 2000, page 1421

• "Automated Imaging Microscope System". Jason Neudorf and Steven A. Garan; Linux Journal 2000, Issue 70, February, Page 32-35

[edit] External links

• Aging Research Center