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The standard enthalpy of combustion is the enthalpy change when one mole of a substance completely reacts under standard thermodynamic conditions (although experimental values are usually obtained under different conditions and subsequently adjusted). By definition, combustion reactions are generally strongly exothermic and so enthalpies of combustion are generally strongly negative.

It is commonly denoted as \Delta H ^{\circ} _{\mathrm{comb}} or \Delta H ^{\circ}_{\mathrm{c}}. When the enthalpy required is not a combustion, it can be denoted as \Delta H ^{\circ} _{\mathrm{total}}. Enthalpies of combustion are typically measured using bomb calorimetry, and have units of energy (typically kJ); strictly speaking, the enthalpy change per mole of substance combusted is the standard molar enthalpy of combustion (which typically would have units of kJ mol−1).

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