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squalene epoxidase
	Chemical reaction catalyzed by squalene epoxidase.
Identifiers
Symbol	SQLE
Entrez	6713
HUGO	11279
OMIM	602019
RefSeq	NM_003129
UniProt	Q14534
Other data
EC number	1.14.99.7
Locus	Chr. 8 q24.1

Squalene monooxygenase (or squalene epoxidase) is an enzyme that uses NADPH and molecular oxygen to oxidize squalene to 2,3-oxidosqualene (squalene epoxide). Squalene epoxidase catalyzes the first oxygenation step in sterol biosynthesis and is thought to be one of the rate-limiting enzymes in this pathway.^[1] In humans, squalene epoxidase is encoded by the SQLE gene.^[2]

[edit] Inhibitors

Inhibitors of squalene epoxidase have found application mainly as antifungal drugs:^[3]

Since squalene epoxidase is on the biosynthetic pathway leading to cholesterol, inhibitors of this enzyme may also find application in treatment of hypercholesterolemia.^[5]

[edit] See also

Antifungal_drug#Allylamines

[edit] References

^ "Entrez Gene: SQLE squalene epoxidase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6713.
^ Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T (August 1997). "Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1". Genomics 44 (1): 141–3. doi:10.1006/geno.1997.4825. PMID 9286711.
^ Favre B, Ryder NS (February 1996). "Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents". Antimicrob. Agents Chemother. 40 (2): 443–7. PMID 8834895. PMC 163131. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8834895.
^ Ryder NS (February 1992). "Terbinafine: mode of action and properties of the squalene epoxidase inhibition". Br. J. Dermatol. 126 Suppl 39: 2–7. PMID 1543672.
^ Chugh A, Ray A, Gupta JB (January 2003). "Squalene epoxidase as hypocholesterolemic drug target revisited". Prog. Lipid Res. 42 (1): 37–50. PMID 12467639. http://linkinghub.elsevier.com/retrieve/pii/S0163782702000292.

[edit] External links

MeSH Squalene+monooxygenase

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[entrez_6713-0] "Entrez Gene: SQLE squalene epoxidase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6713.

[pmid9286711-1] Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T (August 1997). "Localization of the squalene epoxidase gene (SQLE) to human chromosome region 8q24.1". Genomics 44 (1): 141–3. doi:10.1006/geno.1997.4825. PMID 9286711.

[pmid8834895-2] Favre B, Ryder NS (February 1996). "Characterization of squalene epoxidase activity from the dermatophyte Trichophyton rubrum and its inhibition by terbinafine and other antimycotic agents". Antimicrob. Agents Chemother. 40 (2): 443–7. PMID 8834895. PMC 163131. http://aac.asm.org/cgi/pmidlookup?view=long&pmid=8834895.

[pmid1543672-3] Ryder NS (February 1992). "Terbinafine: mode of action and properties of the squalene epoxidase inhibition". Br. J. Dermatol. 126 Suppl 39: 2–7. PMID 1543672.

[pmid12467639-4] Chugh A, Ray A, Gupta JB (January 2003). "Squalene epoxidase as hypocholesterolemic drug target revisited". Prog. Lipid Res. 42 (1): 37–50. PMID 12467639. http://linkinghub.elsevier.com/retrieve/pii/S0163782702000292.

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Contents

[edit] Inhibitors

[edit] See also

[edit] References

[edit] External links