Look up spleen in Wiktionary, the free dictionary.

The spleen is an organ located in the abdomen of the human body.

Spleen may also refer to:

• Billy 'Bill-E' Spleen, a character from the novel series The Demonata
• Spleen (Zang), a set of interrelated parts in traditional Chinese anatomy
• Spleen (musician), a rapper/musician who sometimes performs with CocoRosie
• The Spleen (Music Band), a pop rock group from Quebec, (Canada)
• The Spleen, a character in the 1999 superhero parody movie Mystery Men.
• Spleen (band), a russian rock band

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