Spire may refer to: - A spire, tapering conical or pyramidal structure on the top of a building.
- The Spire of Dublin
- Spire, a character from Metroid Prime Hunters.
- Blackrock Spire, an instance dungeon in World of Warcraft.
- Endar Spire, an interstellar spaceship from Star Wars: Knights of the Old Republic
- Chicago Spire, a proposed supertall skyscraper in Chicago
- The Spire is a location in the Planescape setting of Dungeons and Dragons
- The Spire, a 1964 novel by William Golding
- Spire (mollusc)
- Spire Christian Comics
- Spire FM
- Spire is also a brand of Fanner Group.
- SPIRE, Seeding Postdoctoral Innovators in Research and Education, a three year postdoctoral program at the University of North Carolina-Chapel Hill designed to provide educational training to scientific researchers.
- Spire is an age in the Myst IV computer game.
- The Spire is a column of gas and dust within the Eagle Nebula.
- Spire Healthcare, a company which owns several private hospitals in the United Kingdom which were previously owned by BUPA.
- SPIRE - SPatial Information REpository - An Oracle Spatial government (Defra) database and web portal supporting around 500 spatial datasets. See - http://www.defra.gov.uk/corporate/gi/spire/ could be the UK proof of concept for INSPIRE (INfrastructure for SPatial InfoRmation in the European Community (http://inspire.jrc.ec.europa.eu/index.cfm)
- SPIRE (Spectral and Photometric Imaging Receiver), an instrument on the Herschel Space Observatory.
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