Spectinomycin

Systematic (IUPAC) name
(1R,3S,5R,8R,10R,11S,12S,13R,14S)-8,12,14-trihydroxy-5-methyl-11,13-bis(methylamino)-2,4,9-trioxatricyclo[8.4.0.03,8]tetradecan-7-one
Identifiers
CAS number	1695-77-8
ATC code	J01XX04
PubChem	15541
DrugBank	APRD01232
Chemical data
Formula	C14H24N2O7
Mol. mass	332.35 g/mol
Synonyms	(2R,4aR,5aR,6S,7S,8R,9S,9aR,10aS)-4a,7,9-trihydroxy-2-methyl-6,8-bis(methylamino)decahydro-4H-pyrano[2,3-b][1,4]benzodioxin-4-one
Pharmacokinetic data
Bioavailability	?
Metabolism	?
Half life	?
Excretion	?
Therapeutic considerations
Pregnancy cat.	B(US)
Legal status	not available in US
Routes	?

Spectinomycin (marketed as the hydrochloride salt spectinomycin hydrochloride under the trade name Trobicin) is an aminocyclitol antibiotic, closely related to the aminoglycosides, produced by the bacterium Streptomyces spectabilis.

There was a disruption in the supply in 2001.^[1]

[edit] Mechanism

It binds to the 30S ribosomal subunit in invading bacteria and interrupts protein synthesis.

One form of resistance has emerged in the 16S ribosomal RNA in Pasteurella multocida.^[2]

[edit] Uses

It is given by injection to treat gonorrhea, especially in patients who are allergic to penicillins. This antibiotic is no longer available in the United States

[edit] Side effects

Side effects include itching, chills, stomach-ache, and red rash.

[edit] References

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