Small cell carcinoma Information & Small cell carcinoma Links at HealthHaven.com

Small cell carcinoma
	Classification and external resources
	; Histopathologic image of small cell carcinoma of the lung. CT-guided core needle biopsy. H & E stain.
ICD-O:	M8041/3
MedlinePlus	000122
eMedicine	med/1336
MeSH	D018288

Small cell carcinoma is a type of highly malignant^[1] carcinoma usually associated with the lung, though it can be associated with other topographies, such as in cervical cancer or prostate cancer.

[edit] Types

Paraneoplastic Syndromes: Small cell carcinomas produce ACTH and ADH, which can lead to SIADH.

[edit] Lung

When associated with the lung, it is sometimes called "oat cell carcinoma" due to the flat cell shape and scanty cytoplasm.

It is thought to originate from neuroendocrine cells (APUD cells) in the bronchus called Feyrter cells (named for Friedrich Feyrter),^[2] and often leads to ectopic production of hormones ADH and ACTH.

It is more metastatic than non-small cell lung carcinoma^[3] (and hence staged differently) and is sometimes seen in combination with squamous cell carcinomas.

Smoking is a significant etiological factor.

Symptoms and signs are as for other lung cancers. In addition, because of their neuroendocrine cell origin, small cell carcinomas will often secrete substances that result in paraneoplastic syndromes such as Lambert-Eaton myasthenic syndrome.

[edit] Prostate

In the prostate, small cell carcinoma is a rare form of cancer.^[4] Due to the fact that there is little variation in prostate specific antigen levels, this form of cancer is normally diagnosed at an advanced stage.

It can metastasize to the brain.^[5]

[edit] Treatment

small cell carcinoma is very responsive to chemotherapy and radiotherapy in particular the platinum based agents.however,most people with the disease relapse.

[edit] See also

[edit] References

^ small cell carcinoma at Dorland's Medical Dictionary
^ Champaneria MC, Modlin IM, Kidd M, Eick GN (2006). "Friedrich Feyrter: a precise intellect in a diffuse system". Neuroendocrinology 83 (5-6): 394–404. doi:10.1159/000096050. PMID 17028417. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000096050.
^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 759. ISBN 0-7216-0187-1.
^ Nutting C, Horwich A, Fisher C, Parsons C, Dearnaley DP (June 1997). "Small-cell carcinoma of the prostate". Journal of the Royal Society of Medicine 90 (6): 340–1. PMID 9227387.
^ Erasmus CE, Verhagen WI, Wauters CA, van Lindert EJ (November 2002). "Brain metastasis from prostate small cell carcinoma: not to be neglected". Can J Neurol Sci 29 (4): 375–7. PMID 12463494. http://cjns.metapress.com/openurl.asp?genre=article&issn=0317-1671&volume=29&issue=4&spage=375.

[edit] Additional images

Anaplastic (microcellular, oat cell) carcinoma from the lung (histopathology)

Histopathologic image of small cell carcinoma of the lung. CT-guided core needle biopsy.

[edit] External links

Neuroimmunology - by Abid R Karim, Birmingham UK, at University of Birmingham Medical School
Image at Tulane University
-986382333 at GPnotebook

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[0] small cell carcinoma at Dorland's Medical Dictionary

[pmid17028417-1] Champaneria MC, Modlin IM, Kidd M, Eick GN (2006). "Friedrich Feyrter: a precise intellect in a diffuse system". Neuroendocrinology 83 (5-6): 394–404. doi:10.1159/000096050. PMID 17028417. http://content.karger.com/produktedb/produkte.asp?typ=fulltext&file=000096050.

[isbn0-7216-0187-1-2] Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 759. ISBN 0-7216-0187-1.

[pmid9227387-3] Nutting C, Horwich A, Fisher C, Parsons C, Dearnaley DP (June 1997). "Small-cell carcinoma of the prostate". Journal of the Royal Society of Medicine 90 (6): 340–1. PMID 9227387.

[pmid12463494-4] Erasmus CE, Verhagen WI, Wauters CA, van Lindert EJ (November 2002). "Brain metastasis from prostate small cell carcinoma: not to be neglected". Can J Neurol Sci 29 (4): 375–7. PMID 12463494. http://cjns.metapress.com/openurl.asp?genre=article&issn=0317-1671&volume=29&issue=4&spage=375.

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