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Sebaceous carcinoma
	Classification and external resources
eMedicine	derm/

Sebaceous carcinoma is an aggressive, uncommon, cutaneous tumor,^[1] it is usually of 10 mm size.^[2] This tumor is thought to arise from sebaceous glands in the skin, thus, it may arise anywhere in the body where these glands exist, knowing that the periocular region is rich in this type of gland, so this tumor commonly arise in this region.^[3]^[4] It is usually of unknown etiology, but it may be associated with Muir-Torre syndrome.^[5]^[6]

This tumor usually has a bad prognosis, that is because it tends to metastasize.^[2]

[edit] Pathophysiology

The cell of origin is usually not known. Sebaceous gland carcinoma clearly resembles normal sebaceous glands and is thought to arise from them.^[1]^[2]

[edit] Treatment

Sebaceous gland tumor is commonly managed by innovative techniques of local resection, cryotherapy, topical chemotherapy, and radiotherapy, giving results of improved visual and systemic prognosis.^[3]

Mohs micrographic surgery has a significantly lower recurrence rate and metastatic rate, and excellent results when used as the primary treatment modality for sebaceous carcinoma of the eyelid, it became the teatment of choice for this kind of tumor.^[7]^[4]

[edit] See also

[edit] References

^ ^a ^b Nelson BR, Hamlet KR, Gillard M, Railan D, Johnson TM (July 1995). "Sebaceous carcinoma". J. Am. Acad. Dermatol. 33 (1): 1–15; quiz 16–8. PMID 7601925. http://linkinghub.elsevier.com/retrieve/pii/0190-9622(95)90001-2.
^ ^a ^b ^c Rao NA, Hidayat AA, McLean IW, Zimmerman LE (February 1982). "Sebaceous carcinomas of the ocular adnexa: A clinicopathologic study of 104 cases, with five-year follow-up data". Hum. Pathol. 13 (2): 113–22. PMID 7076199.
^ ^a ^b Shields JA, Demirci H, Marr BP, Eagle RC, Shields CL (2005). "Sebaceous carcinoma of the ocular region: a review". Surv Ophthalmol 50 (2): 103–22. doi:10.1016/j.survophthal.2004.12.008. PMID 15749305. http://linkinghub.elsevier.com/retrieve/pii/S0039-6257(04)00188-2.
^ ^a ^b Callahan EF, Appert DL, Roenigk RK, Bartley GB (August 2004). "Sebaceous carcinoma of the eyelid: a review of 14 cases". Dermatol Surg 30 (8): 1164–8. doi:10.1111/j.1524-4725.2004.30348.x. PMID 15274713. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1076-0512&date=2004&volume=30&issue=8&spage=1164.
^ Cohen PR (August 1992). "Sebaceous carcinomas of the ocular adnexa and the Muir-Torre syndrome". J. Am. Acad. Dermatol. 27 (2 Pt 1): 279–80. PMID 1430382.
^ Rishi K, Font RL (January 2004). "Sebaceous gland tumors of the eyelids and conjunctiva in the Muir-Torre syndrome: a clinicopathologic study of five cases and literature review". Ophthal Plast Reconstr Surg 20 (1): 31–6. doi:10.1097/01.IOP.0000103009.79852.BD. PMID 14752307. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0740-9303&volume=20&issue=1&spage=31.
^ Spencer JM, Nossa R, Tse DT, Sequeira M (June 2001). "Sebaceous carcinoma of the eyelid treated with Mohs micrographic surgery". J. Am. Acad. Dermatol. 44 (6): 1004–9. doi:10.1067/mjd.2001.113692. PMID 11369914. http://linkinghub.elsevier.com/retrieve/pii/S0190-9622(01)47918-7.

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[pmid7601925-0] Nelson BR, Hamlet KR, Gillard M, Railan D, Johnson TM (July 1995). "Sebaceous carcinoma". J. Am. Acad. Dermatol. 33 (1): 1–15; quiz 16–8. PMID 7601925. http://linkinghub.elsevier.com/retrieve/pii/0190-9622(95)90001-2.

[pmid7076199-1] Rao NA, Hidayat AA, McLean IW, Zimmerman LE (February 1982). "Sebaceous carcinomas of the ocular adnexa: A clinicopathologic study of 104 cases, with five-year follow-up data". Hum. Pathol. 13 (2): 113–22. PMID 7076199.

[pmid15749305-2] Shields JA, Demirci H, Marr BP, Eagle RC, Shields CL (2005). "Sebaceous carcinoma of the ocular region: a review". Surv Ophthalmol 50 (2): 103–22. doi:10.1016/j.survophthal.2004.12.008. PMID 15749305. http://linkinghub.elsevier.com/retrieve/pii/S0039-6257(04)00188-2.

[pmid15274713-3] Callahan EF, Appert DL, Roenigk RK, Bartley GB (August 2004). "Sebaceous carcinoma of the eyelid: a review of 14 cases". Dermatol Surg 30 (8): 1164–8. doi:10.1111/j.1524-4725.2004.30348.x. PMID 15274713. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=1076-0512&date=2004&volume=30&issue=8&spage=1164.

[pmid1430382-4] Cohen PR (August 1992). "Sebaceous carcinomas of the ocular adnexa and the Muir-Torre syndrome". J. Am. Acad. Dermatol. 27 (2 Pt 1): 279–80. PMID 1430382.

[pmid14752307-5] Rishi K, Font RL (January 2004). "Sebaceous gland tumors of the eyelids and conjunctiva in the Muir-Torre syndrome: a clinicopathologic study of five cases and literature review". Ophthal Plast Reconstr Surg 20 (1): 31–6. doi:10.1097/01.IOP.0000103009.79852.BD. PMID 14752307. http://meta.wkhealth.com/pt/pt-core/template-journal/lwwgateway/media/landingpage.htm?issn=0740-9303&volume=20&issue=1&spage=31.

[pmid11369914-6] Spencer JM, Nossa R, Tse DT, Sequeira M (June 2001). "Sebaceous carcinoma of the eyelid treated with Mohs micrographic surgery". J. Am. Acad. Dermatol. 44 (6): 1004–9. doi:10.1067/mjd.2001.113692. PMID 11369914. http://linkinghub.elsevier.com/retrieve/pii/S0190-9622(01)47918-7.

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Contents

[edit] Pathophysiology

[edit] Treatment

[edit] See also

[edit] References