Sclerosis or sclerotization is a hardening of tissue and other anatomical features;

• Sclerosis (medicine)
• Cyberbrain Sclerosis, a fictional disease introduced in Ghost in the Shell: Stand Alone Complex. The disease is characterized by hardening of the brain tissues precipitated by the cyberization process.
• a process which hardens plant tissue by adding fibers and sclereids, resulting in sclerenchyma

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