Scalpel may mean:

• Scalpel, a surgical instrument used for cutting
• Laser scalpel, a scalpel which uses a laser, not a blade, for cutting
• SS-24 Scalpel, an intercontinental ballistic missile
• SCALPEL, a system that uses electron beams to print features atoms wide on microchips
• Scalpel (Transformers), a fictional character.

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