Salmonella enterica (formerly Salmonella choleraesuis) is a rod shaped, flagellated, aerobic, Gram-negative bacterium, and a member of the genus Salmonella.[1]
[edit] serovars
S. enterica has an extraordinarily large number of serovars or strains—over 2000 have been described.[2]. The biomedically most relevant subspecies is called S. enterica ssp. enterica, whose following Serovars have special clinical significance in human disease:
- Salmonella enterica Serovar Typhimurium (also known as S. Typhimurium) can lead to a form of human gastroenteritis sometimes referred to as salmonellosis.
- The genome sequences of serovar Typhimurium LT2[4] have been established. Also an analysis of the proteome of Typhimurium LT2 under differing environmental conditions has been performed [5].
- Salmonella enterica Serovar Paratyphi A has been identified.[6] It is associated with paratyphoid fever. It is sometimes known as Salmonella Paratyphi.
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[edit] Pathogenesis
Secreted proteins are of major importance for the pathogenesis of infectious diseases caused by Salmonella enterica. A remarkable large number of fimbrial and non-fimbrial adhesins are present in Salmonella and mediate biofilm formation and contact to host cells. Secreted proteins are also involved in host cell invasion and intracellular proliferation, two hallmarks of Salmonella pathogenesis.[7]
[edit] See also
[edit] References
- ^ Giannella RA (1996). Salmonella. In: Baron's Medical Microbiology (Barron S et al., eds.) (4th ed.). Univ of Texas Medical Branch. (via NCBI Bookshelf) ISBN 0-9631172-1-1.
- ^ Ryan KJ; Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
- ^ Parkhill J et al. (2001). "Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18". Nature 413 (6858): 848–52. doi:10.1038/35101607. PMID doi:[http://dx.doi.org/10.1038%2F35101607 10.1038/35101607 11677608 doi:10.1038/35101607].
- ^ McClelland M et al.. Complete genome sequence of Salmonella enterica serovar Typhimurium LT2sdjksuenjshfuseousef.
- ^ Adkins JN et al. (2006). "Analysis of the Salmonella typhimurium Proteome through Environmental Response toward Infectious Conditions". Molecular and Cellular Proteomics 5: 1450–1461. doi:10.1074/mcp.M600139-MCP200. PMID 16684765.
- ^ Huang H, Li J, Yang XL, et al. (January 2009). "Sequence Analysis of the Plasmid pGY1 Harbored in Salmonella enterica Serovar Paratyphi A". Biochem. Genet. 47: 191. doi:10.1007/s10528-008-9216-0. PMID 19169860.
- ^ Hensel M (2009). "Secreted Proteins and Virulence in Salmonella enterica". Bacterial Secreted Proteins: Secretory Mechanisms and Role in Pathogenesis. Caister Academic Press. ISBN 978-1-904455-42-4.
[edit] External links