Saint-Claude or St. Claude can refer to:

Canada

• St. Claude, Manitoba, the largest community in the Rural Municipality of Grey
• Saint-Claude, Quebec, a municipality of Le Val-Saint-François, a Municipalité régionale de comté of Quebec

France

• Avignon-lès-Saint-Claude, in the département of Jura
• Saint-Claude, Guadeloupe, in the département d'outre-mer Guadeloupe
• Saint-Claude, Jura, in the département of Jura
• Saint-Claude-de-Diray, in the département Loir-et-Cher

United States

• St. Claude, New Orleans, Louisiana, a neighborhood

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