STIM1 Information & STIM1 Links at HealthHaven.com

Stromal interaction molecule 1
Identifiers
Symbols	STIM1; D11S4896E; GOK
External IDs	OMIM: 605921 MGI: 107476 HomoloGene: 20681 GeneCards: STIM1 Gene
Gene ontology
Molecular function	• calcium ion binding; • protein binding;
Cellular component	• endoplasmic reticulum; • integral to plasma membrane; • membrane; • integral to endoplasmic reticulum membrane;
Biological process	• detection of calcium ion; • ion transport; • activation of store-operated calcium channel activity; • regulation of calcium ion transport;
RNA expression pattern
	More reference expression data
Orthologs

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Stromal interaction molecule 1 is a protein that in humans is encoded by the STIM1 gene.^[1]^[2]^[3] STIM1 has a single transmembrane domain, and is localized to the endoplasmic reticulum, and to a lesser extent to the plasma membrane.

Even though the protein has been identified earlier, its function was unknown until recently. In 2005, it was discovered that STIM1 functions as a calcium sensor in the endoplasmic reticulum^[4]^[5]. Upon activation of the IP3 receptor, the calcium concentration in the endoplasmic reticulum decreases, which is sensed by STIM1, via its EF hand domain. STIM1 activates the "store-operated" ORAI1 calcium ion channels in the plasma membrane, via protein protein interaction ^[6].

[edit] Interactions

STIM1 has been shown to interact with STIM2.^[2]

[edit] References

^ Parker NJ, Begley CG, Smith PJ, Fox RM (Feb 1997). "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5". Genomics 37 (2): 253–6. doi:10.1006/geno.1996.0553. PMID 8921403.
^ ^a ^b Williams RT, Manji SS, Parker NJ, Hancock MS, Van Stekelenburg L, Eid JP, Senior PV, Kazenwadel JS, Shandala T, Saint R, Smith PJ, Dziadek MA (Jul 2001). "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins". Biochem J 357 (Pt 3): 673–85. PMID 11463338.
^ Williams RT, Senior PV, Van Stekelenburg L, Layton JE, Smith PJ, Dziadek MA (May 2002). "Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation". Biochim Biophys Acta 1596 (1): 131–7. PMID 11983428.
^ Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA. (2005). "STIM1, an essential and conserved component of store-operated Ca2+ channel function". J.Cell.Biol. 169: 435–45. PMID 15866891.
^ Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T. (2005). "STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx". Curr. Biol. 15: 1235–41. PMID 16005298.
^ Putney JW. "Capacitative calcium entry: from concept to molecules.". Immunol Rev 231: 10–22. PMID 19754887.

This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.

[pmid8921403-0] Parker NJ, Begley CG, Smith PJ, Fox RM (Feb 1997). "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5". Genomics 37 (2): 253–6. doi:10.1006/geno.1996.0553. PMID 8921403.

[pmid11463338-1] Williams RT, Manji SS, Parker NJ, Hancock MS, Van Stekelenburg L, Eid JP, Senior PV, Kazenwadel JS, Shandala T, Saint R, Smith PJ, Dziadek MA (Jul 2001). "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins". Biochem J 357 (Pt 3): 673–85. PMID 11463338.

[pmid11983428-2] Williams RT, Senior PV, Van Stekelenburg L, Layton JE, Smith PJ, Dziadek MA (May 2002). "Stromal interaction molecule 1 (STIM1), a transmembrane protein with growth suppressor activity, contains an extracellular SAM domain modified by N-linked glycosylation". Biochim Biophys Acta 1596 (1): 131–7. PMID 11983428.

[3] Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA. (2005). "STIM1, an essential and conserved component of store-operated Ca2+ channel function". J.Cell.Biol. 169: 435–45. PMID 15866891.

[pmid16005298-4] Liou J, Kim ML, Heo WD, Jones JT, Myers JW, Ferrell JE Jr, Meyer T. (2005). "STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx". Curr. Biol. 15: 1235–41. PMID 16005298.

[pmid19754887-5] Putney JW. "Capacitative calcium entry: from concept to molecules.". Immunol Rev 231: 10–22. PMID 19754887.

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