SOCS7 Information & SOCS7 Links at HealthHaven.com

Suppressor of cytokine signaling 7
Identifiers
Symbols	SOCS7; NAP4
External IDs	OMIM: 608788 MGI: 2651588 HomoloGene: 16331
Gene ontology
Molecular function	• protein binding; • SH3 domain binding;
Cellular component	• cellular_component;
Biological process	• regulation of cell growth; • intracellular signaling cascade; • biological_process; • insulin receptor signaling pathway; • negative regulation of signal transduction; • protein ubiquitination; • fat cell differentiation;
RNA expression pattern
	More reference expression data
Orthologs
XP_941665 (protein)	XP_998664 (protein)

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Suppressor of cytokine signaling 7 is a protein that in humans is encoded by the SOCS7 gene.^[1]^[2]^[3]

[edit] Interactions

SOCS7 has been shown to interact with NCK1.^[1]

[edit] References

^ ^a ^b Matuoka K, Miki H, Takahashi K, Takenawa T (Nov 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochem Biophys Res Commun 239 (2): 488-92. doi:10.1006/bbrc.1997.7492. PMID 9344857.
^ Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci 27 (5): 235-41. PMID 12076535.
^ "Entrez Gene: SOCS7 suppressor of cytokine signaling 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30837.

[edit] Further reading

Cooney RN (2002). "Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathway.". Shock 17 (2): 83–90. doi:10.1097/00024382-200202000-00001. PMID 11837794.
Wormald S, Hilton DJ (2004). "Inhibitors of cytokine signal transduction.". J. Biol. Chem. 279 (2): 821–4. doi:10.1074/jbc.R300030200. PMID 14607831.
Fujimoto M, Naka T (2004). "Regulation of cytokine signaling by SOCS family molecules.". Trends Immunol. 24 (12): 659–66. doi:10.1016/j.it.2003.10.008. PMID 14644140.
Hilton DJ, Richardson RT, Alexander WS, et al. (1998). "Twenty proteins containing a C-terminal SOCS box form five structural classes.". Proc. Natl. Acad. Sci. U.S.A. 95 (1): 114–9. doi:10.1073/pnas.95.1.114. PMID 9419338.
Dogusan Z, Hooghe-Peters EL, Berus D, et al. (2000). "Expression of SOCS genes in normal and leukemic human leukocytes stimulated by prolactin, growth hormone and cytokines.". J. Neuroimmunol. 109 (1): 34–9. doi:10.1016/S0165-5728(00)00300-3. PMID 10969179.
Krebs DL, Uren RT, Metcalf D, et al. (2002). "SOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardation.". Mol. Cell. Biol. 22 (13): 4567–78. doi:10.1128/MCB.22.13.4567-4578.2002. PMID 12052866.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Martens N, Wery M, Wang P, et al. (2004). "The suppressor of cytokine signaling (SOCS)-7 interacts with the actin cytoskeleton through vinexin.". Exp. Cell Res. 298 (1): 239–48. doi:10.1016/j.yexcr.2004.04.002. PMID 15242778.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Martens N, Uzan G, Wery M, et al. (2005). "Suppressor of cytokine signaling 7 inhibits prolactin, growth hormone, and leptin signaling by interacting with STAT5 or STAT3 and attenuating their nuclear translocation.". J. Biol. Chem. 280 (14): 13817–23. doi:10.1074/jbc.M411596200. PMID 15677474.
Banks AS, Li J, McKeag L, et al. (2005). "Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.". J. Clin. Invest. 115 (9): 2462–71. doi:10.1172/JCI23853. PMID 16127460.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045–9. doi:10.1038/nature04689. PMID 16625196.
Kremer BE, Adang LA, Macara IG (2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.". Cell 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMID 17803907.

This article on a gene on chromosome 17 is a stub. You can help Wikipedia by expanding it.

[pmid9344857-0] Matuoka K, Miki H, Takahashi K, Takenawa T (Nov 1997). "A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs". Biochem Biophys Res Commun 239 (2): 488-92. doi:10.1006/bbrc.1997.7492. PMID 9344857.

[pmid12076535-1] Kile BT, Schulman BA, Alexander WS, Nicola NA, Martin HM, Hilton DJ (Jun 2002). "The SOCS box: a tale of destruction and degradation". Trends Biochem Sci 27 (5): 235-41. PMID 12076535.

[entrez-2] "Entrez Gene: SOCS7 suppressor of cytokine signaling 7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30837.

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