SME may stand for: - Small and medium enterprises, a synonym for Small and Medium-sized Business(es) (SMB)
- SME (newspaper), Slovak daily newspapers
- SME Server, a Linux firewall/server distribution
- Social Market Economy, an economic model used in Europe / West Germany
- Socialist Market Economy, an economic system of the People's Republic of China
- Society of Manufacturing Engineers, a professional membership organization for engineers
- Sony Music Entertainment, a record label
- Spontaneous Music Ensemble
- Structure mapping engine, analogy-based AI technology by Ken Forbus based on Dedre Gentner's structure-mapping theory
- Sloppy Meateaters, a former band from Rome, Georgia, United States.
- Special Materials Expert, a sub-specialisation in some military forces.
- Significant Military Equipment, a category of equipment as indicated in the US munitions list
- Solar Mesosphere Explorer, a NASA artificial satellite.
- Society for Mining, Metallurgy, and Exploration
- Subject Matter Expert, especially as related to quality engineering or manufacturing processes
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