SHC1 Information & SHC1 Links at HealthHaven.com

SHC (Src homology 2 domain containing) transforming protein 1
	PDB rendering based on 1mil.
Available structures
	1mil, 1n3h, 1oy2, 1shc, 1tce
Identifiers
Symbols	SHC1; FLJ26504; SHC; SHCA; p52SHC; p66; p66SHC
External IDs	OMIM: 600560 MGI: 98296 HomoloGene: 7934
Gene ontology
Molecular function	• transmembrane receptor protein tyrosine kinase adaptor protein activity; • insulin receptor binding; • insulin-like growth factor receptor binding; • protein binding; • phospholipid binding;
Cellular component	• plasma membrane;
Biological process	• activation of MAPK activity; • regulation of cell growth; • regulation of epidermal growth factor receptor activity; • intracellular signaling cascade; • positive regulation of cell proliferation; • positive regulation of mitosis;
RNA expression pattern
	More reference expression data
Orthologs
NP_003020 (protein)	NP_035498 (protein)

SHC-transforming protein 1 is a protein that in humans is encoded by the SHC1 gene.^[1]

[edit] References

^ Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG (Aug 1992). "A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction". Cell 70 (1): 93-104. PMID 1623525.

Sasaoka T, Kobayashi M (2000). "The functional significance of Shc in insulin signaling as a substrate of the insulin receptor.". Endocr. J. 47 (4): 373–81. doi:10.1507/endocrj.47.373. PMID 11075717.
Ravichandran KS (2001). "Signaling via Shc family adapter proteins.". Oncogene 20 (44): 6322–30. doi:10.1038/sj.onc.1204776. PMID 11607835.
van der Geer P (2002). "Phosphorylation of LRP1: regulation of transport and signal transduction.". Trends Cardiovasc. Med. 12 (4): 160–5. doi:10.1016/S1050-1738(02)00154-8. PMID 12069755.

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