Sapo is the Portuguese and Spanish term for a toad. It may also refer to:

• Mount Sapo, fictitious mountain in Italy
• Mount Sapo, real mountain in Cochabamba Department, Bolivia; see Cerro Sapo (Bolivia)
• Mount Sapo, real mountain in Darién Province, Panama; see Cerro Sapo (Panama)
• Sapo (guitarist), Portuguese guitar player for rock band Mão Morta
• Sapo language, a Niger-Congo language of Liberia
• Sapo National Park, a national park in Sinoe County, Liberia

SAPO or SÄPO may refer to:

• SAPO, a silico-alumino-phosphate (a type of zeolite or molecular sieve)
• SAPO (company) Serviço de Apontadores Portugueses Online(Search engine), a subsidiary of Portugal Telecom Group
• SAPO (computer), the first Czechoslovak computer
• SÄPO, the Swedish Security Service
• South African Port Operations (SAPO), the port management subsidiary of Transnet
• South African Post Office (SAPO), Postal Service Provider in South Africa

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