The abbreviation SAFC or S.A.F.C. may refer to:

• Sunderland A.F.C., a football (soccer) team competing in the English Premiership.

Other uses in sport:

• Scarborough Athletic F.C., an English football (soccer) team
• Stirling Albion F.C. a football (soccer) team competing in the Scottish Football League
• South Adelaide Football Club, an Australian rules football team competing in the South Australian National Football League.
• Sunderland Albion F.C., a defunct football (soccer) from Sunderland

In business:

• Southern Appalachian Forest Coalition
• Sigma-Aldrich Fine Chemicals, a subdivision of Sigma-Aldrich, a supplier of chemical materials
• The former Stock Exchange code for Safeco, an American insurance company

In media:

• South Australian Film Corporation

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