S100A7 Information & S100A7 Links at HealthHaven.com

S100 calcium binding protein A7
	PDB rendering based on 1psr.
Available structures
	1psr, 2psr, 3psr
Identifiers
Symbols	S100A7; PSOR1; S100A7c
External IDs	OMIM: 600353 HomoloGene: 48150
Gene ontology
Molecular function	• calcium ion binding; • protein binding; • zinc ion binding;
Cellular component	• extracellular region; • nucleus; • cytoplasm; • endoplasmic reticulum; • cytosol; • focal adhesion;
Biological process	• response to reactive oxygen species; • angiogenesis; • epidermis development; • keratinocyte differentiation; • innate immune response; • defense response to Gram-negative bacterium; • sequestering of metal ion;
RNA expression pattern
	More reference expression data
Orthologs
NP_002954 (protein)	n/a (protein)

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Protein S100-A7 is a protein that in humans is encoded by the S100A7 gene.^[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility. The protein functions as a prominent antimicrobial peptide mainly against E. coli.^[2]

[edit] Interactions

S100A7 has been shown to interact with COP9 constitutive photomorphogenic homolog subunit 5,^[3] FABP5^[4]^[5] and RANBP9.^[6]

[edit] References

^ Madsen P, Rasmussen HH, Leffers H, Honore B, Dejgaard K, Olsen E, Kiil J, Walbum E, Andersen AH, Basse B, et al. (Nov 1991). "Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin". J Invest Dermatol 97 (4): 701-12. PMID 1940442.
^ "Entrez Gene: S100A7 S100 calcium binding protein A7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6278.
^ Emberley, Ethan D; Niu Yulian, Leygue Etienne, Tomes Ladislav, Gietz R Daniel, Murphy Leigh C, Watson Peter H (Apr. 2003). "Psoriasin interacts with Jab1 and influences breast cancer progression". Cancer Res. (United States) 63 (8): 1954-61. ISSN 0008-5472. PMID 12702588.
^ Ruse, Monica; Broome Ann-Marie, Eckert Richard L (Jul. 2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. (United States) 121 (1): 132-41. doi:10.1046/j.1523-1747.2003.12309.x. ISSN 0022-202X. PMID 12839573.
^ Hagens, G; Roulin K, Hotz R, Saurat J H, Hellman U, Siegenthaler G (Feb. 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. (NETHERLANDS) 192 (1-2): 123-8. ISSN 0300-8177. PMID 10331666.
^ Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. 2002). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer". BMC Cancer (England) 2: 28. PMID 12421467.

[edit] Further reading

Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology.". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470.
Watson PH, Leygue ER, Murphy LC (1998). "Psoriasin (S100A7).". Int. J. Biochem. Cell Biol. 30 (5): 567–71. doi:10.1016/S1357-2725(97)00066-6. PMID 9693957.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960–9. doi:10.1002/elps.11501301199. PMID 1286667.
Schäfer BW, Wicki R, Engelkamp D, et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family.". Genomics 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
Hoffmann HJ, Olsen E, Etzerodt M, et al. (1994). "Psoriasin binds calcium and is upregulated by calcium to levels that resemble those observed in normal skin.". J. Invest. Dermatol. 103 (3): 370–5. doi:10.1111/1523-1747.ep12395202. PMID 8077703.
Bürgisser DM, Siegenthaler G, Kuster T, et al. (1996). "Amino acid sequence analysis of human S100A7 (psoriasin) by tandem mass spectrometry.". Biochem. Biophys. Res. Commun. 217 (1): 257–63. doi:10.1006/bbrc.1995.2772. PMID 8526920.
Celis JE, Rasmussen HH, Vorum H, et al. (1996). "Bladder squamous cell carcinomas express psoriasin and externalize it to the urine.". J. Urol. 155 (6): 2105–12. doi:10.1016/S0022-5347(01)66118-4. PMID 8618345.
Brodersen DE, Etzerodt M, Madsen P, et al. (1998). "EF-hands at atomic resolution: the structure of human psoriasin (S100A7) solved by MAD phasing.". Structure 6 (4): 477–89. doi:10.1016/S0969-2126(98)00049-5. PMID 9562557.
Brodersen DE, Nyborg J, Kjeldgaard M (1999). "Zinc-binding site of an S100 protein revealed. Two crystal structures of Ca2+-bound human psoriasin (S100A7) in the Zn2+-loaded and Zn2+-free states.". Biochemistry 38 (6): 1695–704. doi:10.1021/bi982483d. PMID 10026247.
Semprini S, Capon F, Bovolenta S, et al. (1999). "Genomic structure, promoter characterisation and mutational analysis of the S100A7 gene: exclusion of a candidate for familial psoriasis susceptibility.". Hum. Genet. 104 (2): 130–4. doi:10.1007/s004390050925. PMID 10190323.
Hagens G, Masouyé I, Augsburger E, et al. (1999). "Calcium-binding protein S100A7 and epidermal-type fatty acid-binding protein are associated in the cytosol of human keratinocytes.". Biochem. J. 339 ( Pt 2): 419–27. doi:10.1042/0264-6021:3390419. PMID 10191275.
Hagens G, Roulin K, Hotz R, et al. (1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales.". Mol. Cell. Biochem. 192 (1-2): 123–8. doi:10.1023/A:1006894909694. PMID 10331666.
Al-Haddad S, Zhang Z, Leygue E, et al. (1999). "Psoriasin (S100A7) expression and invasive breast cancer.". Am. J. Pathol. 155 (6): 2057–66. PMID 10595935.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. doi:10.1073/pnas.97.7.3491. PMID 10737800.
Ruse M, Lambert A, Robinson N, et al. (2001). "S100A7, S100A10, and S100A11 are transglutaminase substrates.". Biochemistry 40 (10): 3167–73. doi:10.1021/bi0019747. PMID 11258932.
Enerbäck C, Porter DA, Seth P, et al. (2002). "Psoriasin expression in mammary epithelial cells in vitro and in vivo.". Cancer Res. 62 (1): 43–7. PMID 11782356.
Gemmill RM, Bemis LT, Lee JP, et al. (2002). "The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.". Oncogene 21 (22): 3507–16. doi:10.1038/sj.onc.1205437. PMID 12032852.

This article on a gene on chromosome 1 is a stub. You can help Wikipedia by expanding it.

[pmid1940442-0] Madsen P, Rasmussen HH, Leffers H, Honore B, Dejgaard K, Olsen E, Kiil J, Walbum E, Andersen AH, Basse B, et al. (Nov 1991). "Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin". J Invest Dermatol 97 (4): 701-12. PMID 1940442.

[entrez-1] "Entrez Gene: S100A7 S100 calcium binding protein A7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6278.

[pmid12702588-2] Emberley, Ethan D; Niu Yulian, Leygue Etienne, Tomes Ladislav, Gietz R Daniel, Murphy Leigh C, Watson Peter H (Apr. 2003). "Psoriasin interacts with Jab1 and influences breast cancer progression". Cancer Res. (United States) 63 (8): 1954-61. ISSN 0008-5472. PMID 12702588.

[pmid12839573-3] Ruse, Monica; Broome Ann-Marie, Eckert Richard L (Jul. 2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. (United States) 121 (1): 132-41. doi:10.1046/j.1523-1747.2003.12309.x. ISSN 0022-202X. PMID 12839573.

[pmid10331666-4] Hagens, G; Roulin K, Hotz R, Saurat J H, Hellman U, Siegenthaler G (Feb. 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. (NETHERLANDS) 192 (1-2): 123-8. ISSN 0300-8177. PMID 10331666.

[pmid12421467-5] Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. 2002). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer". BMC Cancer (England) 2: 28. PMID 12421467.

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