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Roundup
RoundUp logo
RoundUp logo
Manufacturing Status
Leading Manufacturer: Monsanto
Type: Herbicide
Introduced to Market: 1976[1]
Purposes
Agriculture: non-selective post-emergence weed control
government: Destruction of illegal drugs, cosmetic purposes, and invasive species control
Consumer/Home: Cosmetic purposes
Herbicide Properties
Surfactant: Polyethoxylated tallow amine(most common)
Active Ingredient: isopropylamine salt of Glyphosate
Mode of Action: 5-enolpyruvylshikimate-3-phosphate synthase(EPSPS) inhibitor
This article is about the herbicidal product. For information on the herbicidal main active ingredient, see glyphosate. For other uses, see Round Up (disambiguation).

Roundup is the brand name of a systemic, broad-spectrum herbicide produced by the U.S. company Monsanto and contains the active ingredient glyphosate. Glyphosate is the most used herbicide in the USA [2], and Roundup is the number one selling herbicide worldwide since at least 1980.[3] As of 2009 sales of Roundup herbicides represent about 10% of Monsanto's revenue due to competition from Chinese producers of other glyphosate-based herbicides,[4] the overall Roundup line of products (which includes GM seeds) represents about half of Monsanto's yearly revenue.[5]

Monsanto developed and patented the glyphosate molecule in the 1970s, and marketed Roundup from 1973. It retained exclusive rights in the US until its US patent expired in September, 2000, and maintained a predominant marketshare in countries where the patent expired earlier.

The main active ingredient of roundup is the isopropylamine salt of Glyphosate. Another important ingredient of Roundup is the surfactant POEA (Polyethoxylated tallow amine), which is known for its toxicity in wildlife.[6] It increases herbicide penetration in plant cells.[7]

Monsanto also produces seeds which grow into plants genetically engineered to be tolerant to glyphosate which are known as Roundup Ready crops. The genes contained in these seeds are patented. Such crops allow farmers to use glyphosate as a post-emergence herbicide against most broadleaf and cereal weeds. Soy was the first Roundup Ready crop and was produced at Monsanto's Agracetus Campus located in Middleton, Wisconsin.

Contents

[edit] Regulation

Roundup commercial formulations were never submitted to test by the United States Environmental Protection Agency‎ (EPA), its main active ingredient, glyphosate, received EPA Toxicity Class of III for oral and inhalation exposure.[8]

Beyond the glyphosate salts content, commercial formulations of Roundup contain surfactants, which vary in nature and concentration. As a result, human poisoning with this herbicide is not with the main active ingredient alone but with complex and variable mixtures.[9]

[edit] Human and mammalian health effects

[edit] Toxicity

By 2000, a review published in a Monsanto sponsored journal,[10] conducted by Ian C. Munro (a member of the Cantox scientific and regulatory consulting firm whose role is defined as to "protect client interests while helping our clients achieve milestones and bring products to market"[11]) concluded that "under present and expected conditions of new use, there is no potential for Roundup herbicide to pose a health risk to humans".[12] Monsanto uses that study as the main source to support Roundup safety for humans.[13]

A 2008 scientific study has shown that Roundup formulations and metabolic products cause the death of human embryonic, placental, and umbilical cells in vitro even at low concentrations. The effects were not proportional to the main active ingredient concentrations (glyphosate) but dependent on the nature of the adjuvants used in the Roundup formulation.[14]

Deliberate ingestion of Roundup in quantities ranging from 85-200 ml has resulted in death, although it has also been ingested in quantities as large as 500ml with only mild or moderate symptoms.[15] There is a reasonable correlation between the amount of Roundup ingested and the likelihood of serious systemic sequelae or death. Ingestion of >85 mL of the concentrated formulation is likely to cause significant toxicity in adults. Gastrointestinal corrosive effects, with mouth, throat and epigastric pain and dysphagia are common. Renal and hepatic impairment are also frequent and usually reflect reduced organ perfusion. Respiratory distress, impaired consciousness, pulmonary oedema, infiltration on chest x-ray, shock, arrythmias, renal failure requiring haemodialysis, metabolic acidosis and hyperkalaemia may supervene in severe cases. Bradycardia and ventricular arrhythmias are often present pre-terminally. Dermal exposure to ready-to-use glyphosate formulations can cause irritation and photo-contact dermatitis has been reported occasionally; these effects are probably due to the preservative Proxel (benzisothiazolin-3-one). Severe skin burns are very rare. Inhalation is a minor route of exposure but spray mist may cause oral or nasal discomfort, an unpleasant taste in the mouth, tingling and throat irritation. Eye exposure may lead to mild conjunctivitis, and superficial corneal injury is possible if irrigation is delayed or inadequate.[9]

[edit] Endocrine disruptor

A 2000 in vitro study on mouse MA-10 cells concluded that Roundup inhibited progesterone production by disrupting StAR protein expression.[16]

A 2005 in vitro study on human placental JEG3 cells concluded that the glyphosate disruption of aromatase is facilitated by adjuvants of the Roundup formulation.[17]

A 2009 in vitro experiment with glyphosate formulations on human liver HepG2 cells has observed endocrine disruption at sub-agricultural doses, where a Roundup formulation showed to be the most active formulation. The effects were more dependent on the formulation than on the glyphosate concentration.[18]


[edit] Genetic damage

A 1998 study on mice concluded that Roundup is able to cause genetic damage. The authors concluded that the damage was "not related to the active ingredient, but to another component of the herbicide mixture".[19]

A 2005 study raised concerns over the effects of Roundup in transcription.[20]

A 2009 study on mice has found that a single intraperitoneal injection of Roundup in concentration of 25 mg/kg caused chromosomal aberrations and induction of micronuclei.[21]

A 2009 in vitro experiment with glyphosate formulations on human liver cells has observed DNA damages at sub-agricultural doses, where a Roundup formulation showed to be the most active formulation. The effects were more dependent on the formulation than on the glyphosate concentration.[18]

[edit] Ecologic effects

A 2000 review of the toxicological data on Roundup concluded that "for terrestrial uses of Roundup minimal acute and chronic risk was predicted for potentially exposed nontarget organisms". It also concluded that there were some risks to aquatic organisms exposed to Roundup in shallow water.[22]

[edit] Aquatic effects

Fish and aquatic invertebrates are more sensitive to Roundup than terrestrial organisms.[22] Glyphosate is generally less persistent in water than in soil, with 12 to 60 day persistence observed in Canadian pond water, yet persistence of over a year have been observed in the sediments of ponds in Michigan and Oregon.[8]
The EU classifies Roundup as R51/53 Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.[23]

Although Roundup is not registered for aquatic uses[24] and studies of its effects on amphibians indicate it is toxic to them,[25] scientists have found that it may wind up in small wetlands where tadpoles live due to inadvertent spraying during its application. A recent study found that even at concentrations one-third of the maximum concentrations expected in nature, Roundup still killed up to 71 percent of tadpoles raised in outdoor tanks.[26]

[edit] Environmental degradation and effects

When glyphosate comes into contact with the soil it can be rapidly bound to soil particles and be inactivated.[8] Unbound glyphosate can be degraded by bacteria.[27] Glyphosphate has been shown to increase the infection rate of wheat by fusarium head blight in fields that have been treated with glyphosphate.[28] A 2009 study using a RoundUp formulation has concluded that absorption in plant delays subsequent soil-degradation and can increase glyphosate persistence in soil from two to six times.[29]

In soils, half lives vary from as little as 3 days at a site in Texas, 141 days at a site in Iowa, to between 1–3 years in Swedish forest soils.[30]

A recent study concluded that certain amphibians may be at risk from glyphosate use.[31] One study has shown an effect on growth and survival of earthworms.[32] The results of this study are in conflict with other data and have been criticized on methodological grounds.[22] In other studies nitrogen fixing bacteria have been impaired, and also crop plant susceptibility to disease has been increased.[28][33][34][35][36][37][38]

[edit] False advertising and scientific fraud

[edit] False advertising

In 1996 Monsanto was accused of false and misleading advertising of glyphosate products, prompting a law suit by the New York State attorney general.[39] Monsanto had made claims that its spray-on glyphosate based herbicides, including Roundup, were safer than table salt and "practically non-toxic" to mammals, birds, and fish.[40]

Environmental and consumer rights campaigners brought a case in France in 2001 for presenting Roundup as biodegradable and claiming that it left the soil clean after use; glyphosate, Roundup's main ingredient, is classed by the European Union as "dangerous for the environment" and "toxic for aquatic organisms". In January 2007, Monsanto was convicted of false advertising.[41] The result was confirmed in 2009.[42]

[edit] Scientific fraud

On two occasions the United States Environmental Protection Agency has caught scientists deliberately falsifying test results at research laboratories hired by Monsanto to study glyphosate.[43][44][45] In the first incident involving Industrial Biotest Laboratories, an EPA reviewer stated after finding "routine falsification of data" that it was "hard to believe the scientific integrity of the studies when they said they took specimens of the uterus from male rabbits".[46][47][48] In the second incident of falsifying test results in 1991, the owner of the lab (Craven Labs), and three employees were indicted on 20 felony counts, the owner was sentenced to 5 years in prison and fined 50,000 dollars, the lab was fined 15.5 million dollars and ordered to pay 3.7 million in restitution.[30][49][50] Craven laboratories performed studies for 262 pesticide companies including Monsanto.

Monsanto has stated that the studies have been repeated and that Roundup's EPA certification does not now use any studies from Craven Labs or IBT. Monsanto also said that the Craven Labs investigation was started by the EPA after a pesticide industry task force discovered irregularities.[51]

[edit] Difference between regulatory registered and commercialized formulations

In November 2009 a French environment group (MDRGF) accused Monsanto of using chemicals in Roundup formulations that weren't informed to the country's regulatory bodies and demanded the removal of those products from the market.[52][53]

[edit] Herbicide selection

Resistance evolves after a weed population has been subjected to intense selection pressure in the form of repeated use of a single herbicide.[54] These weeds resistant to the herbicide have been called "Superweeds".[55][56]

The first documented cases of weed resistance to glyphosate were found in Australia, involving rigid ryegrass near Orange, New South Wales.[57] Some farmers in the United States have expressed concern that weeds are now developing with glyphosate resistance, with 13 states now reporting resistance, and this poses a problem to many farmers, including cotton farmers, that are now heavily dependent on glyphosate to control weeds.[58][59] Farmers associations are now reporting 103 biotypes of weeds within 63 weed species with herbicide resistance[58][59]. This problem is likely to be exacerbated by the use of roundup-ready crops [60]. Fifteen weed species have been confirmed as resistant to glyphosate.[54]

[edit] Palmer amaranth

In 2004 a glyphosate resistant variation of palmer amaranth, commonly known as pigweed, was found in Georgia and confirmed by a 2005 study.[61] In 2005 resistance was also found in North Carolina.[62] Glyphosate resistance followed the widespread use of Roundup Ready crops, which lead to an unprecedented selection pressure to glyphosate.[62] The weed variation is now widespread in southeast US.[63] Cases are also reported in Texas[63] and Virginia[64].

[edit] Conyza biotypes

Conyza bonariensis (also known as hairy fleabane and buva) and Conyza Canadensis (known as horseweed or marestail), are other weed species that had lately developed glyphosate resistance.[65][66] A 2008 study on the current situation of glyphosate resistance in South America concluded that "resistance evolution followed intense glyphosate use" and the utilization of glyphosate-resistant soybean crops is a factor encouraging increase in glyphosate use.[67]

[edit] Ryegrass

Glyphosate resistant ryegrass (Lolium) has occurred in most of the Australian agricultural area and other areas of the world. All cases of evolution of resistance to glyphosate in Australia were characterized by intensive use of the herbicide while no other effective weed control practices were used. Studies indicate that resistant ryegrass does not compete well against none resistant plants and their numbers decrease when not grown under conditions of glyphosate application.[68]

[edit] Johnsongrass

Glyphosate resistant Johnson grass (Sorghum halepense) has occurred in Roundup Ready soybean culture in Argentina.[69]

[edit] Genetically modified crops

In 1996, genetically modified Roundup Ready soybeans resistant to Roundup became commercially available, followed by Roundup Ready corn in 1998.[70] Current Roundup Ready crops include soy, maize (corn), canola[71], sugar beet[72] and cotton, with wheat[73] and alfalfa[74] still under development. As of 2005, 87% of U.S. soybean fields were planted with glyphosate resistant varieties.[75][76] While the use of Roundup Ready crops may have increased the usage of herbicides measured in pounds applied per acre,[77] the use of Roundup Ready crops has changed the herbicide use profile away from atrazine, metribuzin, and alachlor[citation needed] which are more likely to be present in run off water.[78]

[edit] Genetic engineering

Some microorganisms have a version of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS: EC 2.5.1.19, 3-phosphoshikimate 1-carboxyvinyltransferase; 5-enolpyruvylshikimate-3-phosphate synthetase; phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase) that is resistant to glyphosate inhibition. The version used in genetically modified crops was isolated from Agrobacterium strain CP4 (CP4 EPSPS) that was resistant to glyphosate.[79][80] The CP4 EPSPS gene was cloned and inserted into soybeans. The CP4 EPSPS gene was engineered for plant expression by fusing the 5' end of the gene to a chloroplast transit peptide derived from the petunia EPSPS. This transit peptide was used because it had shown previously an ability to deliver bacterial EPSPS to the chloroplasts of other plants. The plasmid used to move the gene into soybeans was PV-GMGTO4. It contained three bacterial genes, two CP4 EPSPS genes, and a gene encoding beta-glucuronidase (GUS) from Escherichia coli as a marker. The DNA was injected into the soybeans using the particle acceleration method. Soybean cultivar A54O3 was used for the transformation. The expression of the GUS gene was used as the initial evidence of transformation. GUS expression was detected by a staining method in which the GUS enzyme converts a substrate into a blue precipitate. Those plants that showed GUS expression were then taken and sprayed with glyphosate and their tolerance was tested over many generations.

[edit] Productivity claims

In 1999, a review of Roundup Ready soybean crops found that, compared to the top conventional varieties, they had a 6.7% lower yield[77]. This so called "yield drag" follows the same pattern observed when other traits are introduced into soybeans by conventional breeding.[81] Monsanto claims later patented varieties yield 7-11% higher than their poorly performing initial varieties, closer to those of conventional farming, although the company refrains from citing actual yields [82]. Monsanto's 2006 application to USDA states that RR2 (mon89788) yields 1.6 bu less than RR1(A3244) http://www.aphis.usda.gov/brs/aphisdocs/06_17801p.pdf

[edit] Tradenames

The Roundup trademark is registered with the US Patent Office and still extant. However, glyphosate is no longer under patent, so similar products use it as an active ingredient.[83]

[edit] Other uses

Glyphosate is one of a number of herbicides used by the United States government to spray Colombian coca fields through Plan Colombia. There are reports that widespread application of glyphosate in attempts to destroy coca crops in South America have resulted in the development of glyphosate-resistant strains of coca known as Boliviana negra, which have been selectively bred to be both "Roundup ready" and also larger and higher yielding than the original strains of the plant. [11][84] However, there are no reports of glyphosate-resistant coca in the peer-reviewed literature.[85] In addition, since spraying of herbicides is not permitted in Colombian national parks, this has encouraged coca growers to move into park areas, cutting down the natural vegetation, and establishing coca plantations within park lands.

[edit] Cosmetic purposes

In many cities Roundup is sprayed along the sidewalks and streets, as well as crevices in between pavement where weeds often grow. However up to 24% of the glyphosate from a Roundup formulation applied to hard surfaces can be run off by water.[86] Glyphosate contamination of surface water is highly attributed to urban use.[87]

In many Canadian cities Roundup use for cosmetic purposes is either banned or restricted.[88][89]

[edit] References

  1. ^ http://www.monsanto.com/who_we_are/history.asp
  2. ^ US EPA 2000–2001 Pesticide Market Estimates Agriculture, Home and Garden
  3. ^ Documentary The World According to Monsanto
  4. ^ "The debate over whether Monsanto is a corporate sinner or saint". The Economist. 19 November 2009. http://www.economist.com/displayStory.cfm?story_id=14904184. Retrieved 20 November 2009. 
  5. ^ Cavallaro, Matt (2009-06-26). "The Seeds Of A Monsanto Short Play". Forbes. http://www.forbes.com/2009/06/29/monsanto-potash-fertilizer-personal-finance-investing-ideas-agrium-mosaic.html. Retrieved 2009-07-11. 
  6. ^ Altieri, M. A. (2009). "The Ecological Impacts of Large-Scale Agrofuel Monoculture Production Systems in the Americas". Bulletin of Science Technology & Society 29: 236. doi:10.1177/0270467609333728.  edit
  7. ^ Gammon, Crystal (2009-06-22). "Weed killer kills human cells. Study intensifies debate over 'inert' ingredients.". Environmental Health News. Environmental Health Sciences. http://www.environmentalhealthnews.org/ehs/news/roundup-weed-killer-is-toxic-to-human-cells.-study-intensifies-debate-over-inert-ingredients. Retrieved 2009-07-12. 
  8. ^ a b c U.S. EPA ReRegistration Decision Fact Sheet for Glyphosate (EPA-738-F-93-011) 1993. [1]
  9. ^ a b Review article at of glyphosate poisoning at Pubmed by Bradberry SM, Proudfoot AT, Vale JA. of the National Poisons Information Service (Birmingham Centre) and West Midlands Poisons Unit, City Hospital, Birmingham, UK. National Institutes of Health
  10. ^ "Sponsors 2007". http://www.isrtp.org/sponsors.htm. Retrieved 2009-04-22. [dead link]
  11. ^ "Cantox Homepage". http://www.cantox.com/. Retrieved 2009-04-22. 
  12. ^ Williams GM, Kroes R, Munro IC. (2000) Safety evaluation and risk assessment of the herbicide Roundup and its active ingredient, glyphosate, for humans. Regulatory Toxicology and Pharmacology, 31 (2): 117-165. PMID 10854122.
  13. ^ "Summary of Human Risk Assessment and Safety Evaluation on Glyphosate and Roundup® Herbicide". May 2005. http://www.monsanto.com/monsanto/content/products/productivity/roundup/glyphosate_human_risk_backgrounder.pdf. Retrieved 2009-10-14. 
  14. ^ Benachour, Nora; Gilles-Eric Séralini (December 23, 2008). "Glyphosate Formulations Induce Apoptosis and Necrosis in Human Umbilical, Embryonic, and Placental Cells". Chemical Research in Toxicology. http://pubs.acs.org/doi/abs/10.1021/tx800218n. 
  15. ^ Alan Ronald Talbot, Mon-Han Shiaw, Jinn-Sheng Huang, Shu-Fen Yang, Tein-Shong Goo, Shur-Hueih Wang, Chao-Liang Chen, Thomas Richard Sanford, "Acute Poisoning with a Glyphosate-Surfactant Herbicide ('Roundup'): A Review of 93 Cases", Human & Experimental Toxicology, Vol. 10, No. 1, 1-8 (1991).
  16. ^ Walsh, Lp; Mccormick, C; Martin, C; Stocco, Dm (Aug 2000). "Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression". Environmental health perspectives 108 (8): 769–76. doi:10.2307/3434731. ISSN 0091-6765. PMID 10964798.  edit
  17. ^ Richard, S; Moslemi, S; Sipahutar, H; Benachour, N; Seralini, Ge (Jun 2005). "Differential effects of glyphosate and roundup on human placental cells and aromatase". Environmental health perspectives 113 (6): 716–20. ISSN 0091-6765. PMID 15929894.  edit
  18. ^ a b Gasnier, C.; Dumont, C.; Benachour, N.; Clair, E.; Chagnon, C.; Séralini, E. (Jun 2009). "Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines". Toxicology 262 (3): 184. doi:10.1016/j.tox.2009.06.006. ISSN 0300-483X. PMID 19539684.  edit
  19. ^ Peluso M, Munnia A, Bolognesi C, Parodi S. Environ Mol Mutagen. 1998 31:55-9 PMID 9464316
  20. ^ Marc, J.; Le Breton, M.; Cormier, P.; Morales, J.; Bellé, R.; Mulner-Lorillon, O. (2005). "A glyphosate-based pesticide impinges on transcription". Toxicology and applied pharmacology 203 (1): 1–8. doi:10.1016/j.taap.2004.07.014. PMID 15694458.  edit
  21. ^ Chern, J.; Beutler, E. (Jan 2009). "Clastogenic Effects of Glyphosate in Bone Marrow Cells of Swiss Albino Mice" (PDF). Journal of Toxicology 2009 (01): 1. doi:10.1155/2009/308985. ISSN 0002-9297. PMID 2009. PMC 1684914. http://hindawi.com/RecentlyAcceptedArticlePDF.aspx?journal=jt&number=308985.  edit
  22. ^ a b c JP Giesy, KR Solomon, S Dobson (2000). "Ecotoxicological Risk Assessment for Roundup Herbicide". Reviews of Environmental Contamination and Toxicology 167: 35-120
  23. ^ Monsanto Roundup Material Safety Data sheet page 7, heading 16
  24. ^ Monsanto Backgrounder 2005 Response to "The impact of insecticides and herbicides on the biodiversity and productivity of aquatic communities" [2]
  25. ^ Rick A. Relyea 2005 The impact of insecticides and herbicides on the biodiversity and productivity of aquatic communities Ecological Applications 15:618–627
  26. ^ Even Small Doses of Popular Weed Killer Fatal to Frogs, Scientist Finds [3]
  27. ^ Balthazor, Terry M and Laurence Hallas (1986) Glyphosate-degrading microorganisms in industrial waste treatment biosystems. Appl. Environ. Microbiol. 51:432-34.[4]
  28. ^ a b [5] "Crop Production Factors Associated with Fusarium Head Blight in Spring Wheat in Eastern Saskatchewan", published online 26 August 2005 by M. R. Fernandeza, F. Sellesa, D. Gehlb, R. M. DePauwa and R. P. Zentner.
  29. ^ Doublet; Mamy, L.; Barriuso, E. (2009). "Delayed degradation in soil of foliar herbicides glyphosate and sulcotrione previously absorbed by plants: consequences on herbicide fate and risk assessment". Chemosphere 77 (4): 582–589. doi:10.1016/j.chemosphere.2009.06.044. PMID 19625069.  edit
  30. ^ a b Glyphosate Factsheet (part 1 of 2) Caroline Cox / Journal of Pesticide Reform v.108, n.3 Fall98 rev.Oct00
  31. ^ Bette Hileman. (2005) Common herbicide kills tadpoles. Chemical & Engineering News. Washington 83(15):11.
  32. ^ (Springett & Gray 1992, Soil Biol. Biochem. 24 (12):1739–1744)
  33. ^ (Santos & Flores 1995, Lett. Appl. Microbiol. 20:349-352)
  34. ^ (Brammel & Higgins 1988, Can. J. Bot 66:1547–1555)
  35. ^ (Johal & Rahe 1988, Molec. Plant Pathol. 32:267-281)
  36. ^ (Mekwatanakarn & Sivassithamparam 1987, Biol. Fertil. Soils 5:175-180)
  37. ^ (Kawate et al. 1997, Weed Sci. 45:739-743)
  38. ^ (Bergvinson & Borden 1992, Can J. For. Res. 22:206-209)
  39. ^ Attorney General of the State of New York. Consumer Frauds and Protection Bureau. Environmental Protection Bureau. 1996. In the matter of Monsanto Company, respondent. Assurance of discontinuance pursuant to executive law § 63(15). New York, NY, Nov
  40. ^ "Monsanto pulls Roundup advertising in New York", Wichita Eagle, Nov. 27, 1996.
  41. ^ Monsanto Fined in France for 'False' Herbicide Ads - Organic Consumers Association
  42. ^ "Monsanto guilty in 'false ad' row". BBC. 2009-10-15. http://news.bbc.co.uk/2/hi/europe/8308903.stm. Retrieved 2009-10-16. 
  43. ^ (US EPA Communications and Public Affairs 1991 Note to correspondents Washington DC Mar 1)
  44. ^ (US EPA Communications and Public Affairs 1991 Press Advisory. EPA lists crops associated with pesticides for which residue and environmental fate studies were allegedly manipulated. Washington DC Mar 29)
  45. ^ (U.S. Congress. House of Representatives. Com. on Gov. Oper. 1984. Problems palgue the EPA pesticide registration activities. House Report 98-1147)
  46. ^ (U.S. EPA 1978 Data validation. Memo from K LOcke, Toxicology Branch, to R Taylor, Registration Branch. Washington DC Aug 9)
  47. ^ (U.S. EPA Office of pesticides and Toxic Substances 1983, Summary of the IBT review program. Washington D.C. July)
  48. ^ Schneider, K. 1983. Faking it: The case against Industrial Bio-Test Laboratories. The Amicus Journal (Spring):14-26. Reproduced at Planetwaves
  49. ^ (US Dept. of Justice. United States Attorney. Western District of Texas 1992. Texas laboratory, its president, 3 employees indicted on 20 felony counts in connection with pesticide testing. Austin TX Sept 29)
  50. ^ (US EPA Communications, Education, And Public Affairs 1994 Press Advisory. Craven Laboratories, owner, and 14 employees sentenced for falsifying pesticide tests. Washington DC Mar 4)
  51. ^ Backgrounder: Testing Fraud: IBT and Craven Labs, June 2005, Monsanto background paper on RoundUp[6]
  52. ^ "Round up: une association veut le retrait" (in French). Le Figaro. 2009-11-18. http://www.lefigaro.fr/flash-actu/2009/11/18/01011-20091118FILWWW00547-round-up-une-association-veut-le-retrait.php. Retrieved 19 November 2009. 
  53. ^ "Dossier de presse - alerte pesticides: le cas de 3 Roundup®" (in French). Mouvement pour les droits et le respect des générations futures (MDRGF). 01 November 2009. http://www.mdrgf.org/pdf/Dossier_presse_Roundup_final.pdf. Retrieved 19 November 2009. 
  54. ^ a b U of G Researchers Find Suspected Glyphosate-Resistant Weed
  55. ^ ‘Superweed’ explosion threatens Monsanto heartlands
  56. ^ PJStar.com
  57. ^ ISU Weed Science Online - Are RR Weeds in Your Future II
  58. ^ a b Glyphosate resistance is a reality that should scare some cotton growers into changing the way they do business
  59. ^ a b More glyphosate resistant weeds
  60. ^ Purdue University
  61. ^ Culpepper, A. S. (2006). "Glyphosate-resistant Palmer amaranth (Amaranthus palmeri ) confirmed in Georgia". Weed Science 54: 620–626. doi:10.1614/WS-06-001R.1.  edit
  62. ^ a b Hampton, Natalie. "Cotton versus the monster weed". http://www.cals.ncsu.edu/agcomm/magazine/winter09/cotton.html. Retrieved 2009-07-19. 
  63. ^ a b Smith, J.T. (March 2009). "Resistance a growing problem". The Farmer Stockman. http://magissues.farmprogress.com/TFS/FS03Mar09/tfs024.pdf. Retrieved 2009-07-19. 
  64. ^ Taylor, Owen (2009-07-16). "Peanuts: variable insects, variable weather, Roundup resistant Palmer in new state". PeanutFax. AgFax Media. http://agfax.com/news/2009/peanutfax/0716pf.htm. Retrieved 2009-07-19. 
  65. ^ Vargas, L.; Bianchi, M. A.; Rizzardi, M. A.; Agostinetto, D.; Dal Magro, T. (2007). "Buva (Conyza bonariensis) resistente ao glyphosate na região sul do Brasil". Planta Daninha 25. doi:10.1590/S0100-83582007000300017.  edit
  66. ^ Koger, C. H.; Shaner, D. L.; Henry, W. B.; Nadler-Hassar, T.; Thomas, W. E.; Wilcut, J. W. (2005). "Assessment of two nondestructive assays for detecting glyphosate resistance in horseweed (Conyza canadensis)". Weed Science 53: 438–445. doi:10.1614/WS-05-010R.  edit
  67. ^ Vila-Aiub, M. M.; Vidal, R.; Balbi, M.; Gundel, P.; Trucco, F.; Ghersa, C. (Apr 2008). "Glyphosate-resistant weeds of South American cropping systems: an overview". Pest management science 64 (4): 366–371. doi:10.1002/ps.1488. ISSN 1526-498X. PMID 18161884.  edit
  68. ^ Preston, C.; Wakelin, A. M.; Dolman, F. C.; Bostamam, Y.; Boutsalis, P. (2009). "A Decade of Glyphosate-Resistant Lolium around the World: Mechanisms, Genes, Fitness, and Agronomic Management" (PDF). Weed Science 57: 435–441. doi:10.1614/WS-08-181.1. http://www.allenpress.com/pdf/wees/WEES_57.4_435_441.pdf.  edit
  69. ^ Vila-aiub, M. M.; Balbi, M. C.; Gundel, P. E.; Ghersa, C. M.; Powles, S. B. (2007). "Evolution of Glyphosate-Resistant Johnsongrass (Sorghum halepense) in Glyphosate-Resistant Soybean". Weed Science 55: 566–571. doi:10.1614/WS-07-053.1.  edit
  70. ^ Monsanto Company History
  71. ^ Monsanto Genuity Roundup Ready canola trait
  72. ^ Monsanto Genuity Roundup Ready sugarbeets trait
  73. ^ Agbios GM database entry for wheat event MON71800
  74. ^ Agbios GM database entry for alfalfa events events J101 and J163
  75. ^ USDA/APHIS Environmental Assessment - In response to Monsanto Petition 06-178-01p seeking a Determination of Non-regulated Status for + Roundup RReady2Yield Soybean MON 89788, OECD Unique Identifier MON-89788-1, U.S. Department of Agriculture Animal and Plant Health Inspection Service + Biotechnology Regulatory Services page 13[7]
  76. ^ National Agriculture Statistics Service (2005) in Acreage eds. Johanns, M. & Wiyatt, S. D. 6 30, (U.S. Dept. of Agriculture, Washington, DC). +
  77. ^ a b Charles Benbrook. Evidence of the Magnitude and Consequences of the Roundup Ready Soybean Yield Drag from University-Based Varietal Trials in 1998. Ag BioTech InfoNet Technical Paper Number 1
  78. ^ Impact of glyphosate-tolerant soybean and glufosinate-tolerant corn production on herbicide losses in surface runoff. Shipitalo MJ, Malone RW, Owens LB. J Environ Qual. 2008 37(2):401-8 PMID 18268303
  79. ^ Development and Characterization of a CP4 EPSPS-Based, Glyphosate-Tolerant Corn Event,G. R. Heck et al. Crop Sci. 45:329-339 (2005).[8]
  80. ^ Molecular basis for the herbicide resistance of Roundup Ready crops, T. Funke et al., PNAS 2006 103:13010-13015 [9]
  81. ^ Caviness, C.E., and H.J. Walters. 1971. Effect of phytophthora rot on yield and chemical composition of soybean seed. Crop Science 11:83-84
  82. ^ Roundup Ready 2 Yield- Monsanto Web site http://www.monsanto.com/rr2y/
  83. ^ California Product/Label Database
  84. ^ New Super Strain of Coca Plant Stuns Anti-Drug Officials. Jeremy McDermott. The Scotsman (Scotland) 27 August 2004
  85. ^ USDA National Agricultural Library, accessed 1 Nov 2007
  86. ^ [10]
  87. ^ Botta, F.; Lavison, G.; Couturier, G.; Alliot, F.; Moreau-Guigon, E.; Fauchon, N.; Guery, B.; Chevreuil, M. et al. (May 2009). "Transfer of glyphosate and its degradate AMPA to surface waters through urban sewerage systems". Chemosphere 77 (1): 133–139. doi:10.1016/j.chemosphere.2009.05.008. ISSN 0045-6535. PMID 19482331.  edit
  88. ^ Hamilton Spectator
  89. ^ BCLocalNews.com

[edit] External links

[edit] Further reading

  • Baccara, Mariagiovanna, et al. Monsanto's Roundup, NYU Stern School of Business: August 2001, Revised July 14, 2003.
  • Pease W S et al. (1993) Preventing pesticide-related illness in California agriculture: Strategies and priorities. Environmental Health Policy Program Report. Berkeley, CA: University of California. School of Public Health. California Policy Seminar.
  • Marie-Monique Robin. (2008) Le monde selon Monsanto. Arte Editions (book written in french). ISBN 978-2-7071-4918-3. An overview of Monsanto products: PCB, Dioxine, Roundup, Bovine Growth Hormone, OGM.
  • Wang Y, Jaw C and Chen Y (1994) Accumulation of 2,4-D and glyphosate in fish and water hyaacinth. Water Air Soil Pollute. 74:397-403
Retrieved from "http://en.wikipedia.org/wiki/Roundup"



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