Ribose-phosphate diphosphokinase Information & Ribose-phosphate diphosphokinase Links at HealthHaven.com

phosphoribosyl pyrophosphate synthetase 1
Identifiers
Symbol	PRPS1
Entrez	5631
HUGO	9462
OMIM	311850
RefSeq	NM_002764
UniProt	P60891
Other data
EC number	2.4.2.17
Locus	Chr. X q21-q27

phosphoribosyl pyrophosphate synthetase 2
Identifiers
Symbol	PRPS2
Entrez	5634
HUGO	9465
OMIM	311860
RefSeq	NM_002765
UniProt	P11908
Other data
EC number	2.4.2.17
Locus	Chr. X pter-q21

Ribose-phosphate diphosphokinase (or phosphoribosyl pyrophosphate synthetase) is an enzyme that converts ribose 5-phosphate into phosphoribosyl pyrophosphate.

It is classified under EC 2.7.6.1.

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Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4: phosphotransferase/kinase
(phosphorus-containing group: PO₄)

2.7.1: OH acceptor	Hexo- · Gluco- · Fructo- (Hepatic) · Galacto- · Phosphofructo- (1, Liver, Muscle, Platelet, 2) · Riboflavin · Shikimate · Thymidine (ADP-thymidine) · NAD⁺ · Glycerol · Pantothenate · Mevalonate · Pyruvate · Deoxycytidine · PFP · Diacylglycerol · Phosphoinositide 3 (Class I PI 3, Class II PI 3) · Sphingosine · Glucose-1,6-bisphosphate synthase

2.7.2: COOH acceptor	Phosphoglycerate · Aspartate

2.7.3: N acceptor	Creatine

2.7.4: PO₄ acceptor	Phosphomevalonate · Adenylate · Nucleoside-diphosphate

2.7.6: diphosphotransferase
(phosphorus-containing group: P₂O₇)

Ribose-phosphate diphosphokinase · Thiamine pyrophosphokinase

DNA polymerase	DNA-directed DNA polymerase: DNA polymerase I · DNA polymerase II · DNA polymerase III holoenzyme RNA-directed DNA polymerase: Reverse transcriptase (Telomerase) DNA nucleotidylexotransferase/Terminal deoxynucleotidyl transferase

RNA nucleotidyltransferase	RNA polymerase/DNA-directed RNA polymerase: RNA polymerase I · RNA polymerase II · RNA polymerase III · RNA polymerase IV · Primase · RNA-dependent RNA polymerase PNPase

Other

2.7.8: miscellaneous phosphate-containing groups

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase · CDP-diacylglycerol—serine O-phosphatidyltransferase · CDP-diacylglycerol—inositol 3-phosphatidyltransferase · CDP-diacylglycerol—choline O-phosphatidyltransferase

other	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(phosphorus-containing group: PO₄; protein acceptor)

2.7.10: protein-tyrosine	Bruton's tyrosine

2.7.11: protein-serine/threonine	Serine/threonine-specific

2.7.12: protein-dual-specificity	Dual-specificity kinase · Mitogen-activated protein kinase kinase

2.7.13: protein-histidine	Protein-histidine pros-kinase · Protein-histidine tele-kinase · Histidine kinase

Anabolism	R5P->IMP: Ribose-phosphate diphosphokinase - Amidophosphoribosyltransferase - Phosphoribosylglycinamide formyltransferase - AIR synthetase (FGAM cyclase) - Phosphoribosylaminoimidazole carboxylase - Phosphoribosylaminoimidazolesuccinocarboxamide synthase - IMP synthase IMP->AMP: Adenylosuccinate synthase - Adenylosuccinate lyase - reverse (AMP deaminase) IMP->GMP: IMP dehydrogenase - GMP synthase - reverse (GMP reductase)

Nucleotide salvage	Hypoxanthine-guanine phosphoribosyltransferase - Adenine phosphoribosyltransferase

Catabolism	Adenosine deaminase - Purine nucleoside phosphorylase - Guanine deaminase - Xanthine oxidase - Urate oxidase

Anabolism	CAD (Carbamoyl phosphate synthase II, Aspartate carbamoyltransferase, Dihydroorotase) Dihydroorotate dehydrogenase - Orotidine 5'-phosphate decarboxylase/Uridine monophosphate synthetase CTP synthase

Catabolism	Dihydropyrimidine dehydrogenase - Dihydropyrimidinase/DPYS - Beta-ureidopropionase/UPB1

see also disorders, intermediates