Pre-integration complex Information & Pre-integration complex Links at HealthHaven.com

The pre-integration complex (PIC) is generally composed of the viral genetic material and associated proteins (viral and host) after release into the cell. In HIV, this includes the viral core which surrounds the RNA. This complex is responsible for reverse transcription of the viral RNA genome into dsDNA and prepares it for retroviral integration into the host DNA within the nucleus.^[1]

[edit] See also

HIV

[edit] External links

http://www.mcld.co.uk/hiv/?q=preintegration%20complex

[edit] References

^ Smith, Johanna A.; Nunnari, Giuseppe; Preuss, Mirjam ; Pomerantz, Roger J.; Daniel, René (Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia) (2007). "Pentoxifylline Suppresses Transduction by HIV-1-Based Vectors". Intervirology 50 (5): 377–386. doi:10.1159/000109752.

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[0] Smith, Johanna A.; Nunnari, Giuseppe; Preuss, Mirjam ; Pomerantz, Roger J.; Daniel, René (Division of Infectious Diseases, Center for Human Virology, Thomas Jefferson University, Philadelphia) (2007). "Pentoxifylline Suppresses Transduction by HIV-1-Based Vectors". Intervirology 50 (5): 377–386. doi:10.1159/000109752.

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