Red pulp
Transverse section of a portion of the spleen. (Spleen pulp labeled at lower right.)
Spleen
Latin	pulpa splenica
Gray's	subject #278 1284

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Red pulp of the spleen is composed of connective tissue known as the cords of Billroth and many splenic sinuses that are engorged with blood, giving it a red color.^[1][2] Its primary function is to filter the blood of antigens, microorganisms, and defective or worn-out red blood cells.^[3]

The spleen is made of red pulp and white pulp, separated by the marginal zone; 76-79% of a normal spleen is red pulp.^[4] Unlike white pulp, which mainly contains lymphocytes such as T cells, red pulp is made up of several different types of blood cells, including platelets, granulocytes, red blood cells, and plasma.^[1]

Contents 1 Sinusoids 2 Cells found in red pulp 3 Diseases 4 References 5 External links

[edit] Sinusoids

The splenic sinuses of the spleen, also known as sinusoids, are wide vessels that drain into trabecular veins. Gaps in the endothelium lining the sinusoids mechanically filter blood cells as they enter the spleen. Worn-out or abnormal red cells attempting to squeeze through the narrow intercellular spaces become badly damaged, and are subsequently devoured by macrophages in the red pulp.^[5] In addition to aged red blood cells, the sinusoids also filter out particles that could clutter up the bloodstream, such as nuclear remnants or denatured hemoglobin.

[edit] Cells found in red pulp

Red pulp consists of a dense network of fine reticular fiber, continuous with those of the splenic trabeculae, to which are applied flat, branching cells. The meshes of the reticulum are filled with blood:

• White corpuscles are found to be in larger proportion than they are in ordinary blood.

• Large rounded cells, termed splenic cells, are also seen; these are capable of ameboid movement, and often contain pigment and red-blood corpuscles in their interior.

• The cells of the reticulum each possess a round or oval nucleus, and like the splenic cells, they may contain pigment granules in their cytoplasm; they do not stain deeply with carmine, and in this respect differ from the cells of the Malpighian corpuscles.

• In the young spleen, macrophages may also be found, each containing numerous nuclei or one compound nucleus.

• Nucleated red-blood corpuscles have also been found in the spleen of young animals.

[edit] Diseases

In lymphoid leukemia, the white pulp of the spleen hypertrophies and the red pulp shrinks.^[4] In some cases the white pulp can swell to 50% of the total volume of the spleen.^[6] In myeloid leukemia, the white pulp atrophies and the red pulp expands.^[4]

[edit] References

[edit] External links

• Anatomy Atlases - Microscopic Anatomy, plate 09.175 - "Spleen: Red Pulp"
• red+pulp at eMedicine Dictionary
• Diagram at kctcs.edu
• Description and diagram at apsu.edu

This article was originally based on an entry from a public domain edition of Gray's Anatomy. As such, some of the information contained within it may be outdated.

v • d • e Immune system: Lymphatic system (Lymph, Lymphocytes, Lymph vessels) (TA A13.1-2, GA 8) Primary Bone marrow · Thymus (Hassall's corpuscles) Secondary Spleen (process blood) structural: Hilum · Trabeculae Red pulp (Cords of Billroth, Marginal zone) White pulp (Periarteriolar lymphoid sheaths, Germinal center) blood flow: Trabecular arteries · Trabecular veins Lymph nodes (process extracellular fluid) lymph flow: Afferent lymph vessels · Cortical sinuses · Medullary sinuses · Efferent lymph vessels T cells: High endothelial venules B cells: Primary follicle/Germinal center · Mantle zone · Marginal zone layers: Capsule/Trabeculae · Subcapsular sinus · Cortex · Paracortex · Medulla (Medullary cord) · Hilum MALT (process mucosa) GALT · Peyer's patches · Germinal center lymphatic organ navs: anat, physio, lymphatic disease/splenic disease/thymus disorders/thymus neoplasia/vascular tumors, proc