RSPO2 Information & RSPO2 Links at HealthHaven.com

R-spondin-2 , also known as RSPO2, is a gene that determines hair growth in dog coats.^[1] It synergizes with Wnt to activate beta-catenin.^[2]

[edit] References

^ Cadieu E, Neff M, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. (2009). Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes. Science. 326:150-153. doi:10.1126/science.1177808 PMID 19713490
^ Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. (2004). R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell. 7(4):525-34. PMID 15469841

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[Cadieu-0] Cadieu E, Neff M, Quignon P, Walsh K, Chase K, Parker HG, Vonholdt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. (2009). Coat Variation in the Domestic Dog Is Governed by Variants in Three Genes. Science. 326:150-153. doi:10.1126/science.1177808 PMID 19713490

[1] Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. (2004). R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell. 7(4):525-34. PMID 15469841

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