RICS (gene) Information & RICS (gene) Links at HealthHaven.com

Rho GTPase-activating protein
Identifiers
Symbols	RICS; GC-GAP; GRIT; KIAA0712; MGC1892; p200RhoGAP; p250GAP
External IDs	OMIM: 608541 MGI: 2450166 HomoloGene: 8812
Gene ontology
Cellular component	• intracellular;
Biological process	• signal transduction;
RNA expression pattern
	More reference expression data
Orthologs
NP_055530 (protein)	NP_796353 (protein)

edit

Rho GTPase-activating protein, also known as RICS, is a human gene.^[1]

RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003).[supplied by OMIM]^[1]

[edit] Interactions

RICS (gene) has been shown to interact with BCAR1,^[2]^[3] FYN,^[4] TrkA,^[3] Src,^[5] NCK1,^[2] GAB2,^[2] SHC3,^[3] RAC1,^[2]^[5] RHOA,^[6]^[3]^[5] GRIN2B,^[6] CRKL,^[3] CDC42^[6]^[2]^[3] and CRK.^[2]^[5]

[edit] References

^ ^a ^b "Entrez Gene: RICS Rho GTPase-activating protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9743.
^ ^a ^b ^c ^d ^e ^f Zhao, Chunmei; Ma Hong, Bossy-Wetzel Ella, Lipton Stuart A, Zhang Zhuohua, Feng Gen-Sheng (Sep. 2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". J. Biol. Chem. (United States) 278 (36): 34641-53. doi:10.1074/jbc.M304594200. ISSN 0021-9258. PMID 12819203.
^ ^a ^b ^c ^d ^e ^f Nakamura, Takeshi; Komiya Misako, Sone Kiyoaki, Hirose Eiji, Gotoh Noriko, Morii Hiroshi, Ohta Yasutaka, Mori Nozomu (Dec. 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. (United States) 22 (24): 8721-34. ISSN 0270-7306. PMID 12446789.
^ Taniguchi, Sachiko; Liu Hui, Nakazawa Takanobu, Yokoyama Kazumasa, Tezuka Tohru, Yamamoto Tadashi (Jun. 2003). "p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn". Biochem. Biophys. Res. Commun. (United States) 306 (1): 151-5. ISSN 0006-291X. PMID 12788081.
^ ^a ^b ^c ^d Moon, Sun Young; Zang Heesuk, Zheng Yi (Feb. 2003). "Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP". J. Biol. Chem. (United States) 278 (6): 4151-9. doi:10.1074/jbc.M207789200. ISSN 0021-9258. PMID 12454018.
^ ^a ^b ^c Nakazawa, Takanobu; Watabe Ayako M, Tezuka Tohru, Yoshida Yutaka, Yokoyama Kazumasa, Umemori Hisashi, Inoue Akihiro, Okabe Shigeo, Manabe Toshiya, Yamamoto Tadashi (Jul. 2003). "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling". Mol. Biol. Cell (United States) 14 (7): 2921-34. doi:10.1091/mbc.E02-09-0623. ISSN 1059-1524. PMID 12857875.

[edit] Further reading

Hayashi T, Okabe T, Nasu-Nishimura Y, et al. (2007). "PX-RICS, a novel splicing variant of RICS, is a main isoform expressed during neural development.". Genes Cells 12 (8): 929–39. doi:10.1111/j.1365-2443.2007.01101.x. PMID 17663722.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.". Mol. Cell Proteomics 4 (6): 785–95. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Nakazawa T, Watabe AM, Tezuka T, et al. (2004). "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling.". Mol. Biol. Cell 14 (7): 2921–34. doi:10.1091/mbc.E02-09-0623. PMID 12857875.
Zhao C, Ma H, Bossy-Wetzel E, et al. (2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2.". J. Biol. Chem. 278 (36): 34641–53. doi:10.1074/jbc.M304594200. PMID 12819203.
Taniguchi S, Liu H, Nakazawa T, et al. (2003). "p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn.". Biochem. Biophys. Res. Commun. 306 (1): 151–5. doi:10.1016/S0006-291X(03)00923-9. PMID 12788081.
Okabe T, Nakamura T, Nishimura YN, et al. (2003). "RICS, a novel GTPase-activating protein for Cdc42 and Rac1, is involved in the beta-catenin-N-cadherin and N-methyl-D-aspartate receptor signaling.". J. Biol. Chem. 278 (11): 9920–7. doi:10.1074/jbc.M208872200. PMID 12531901.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gardiner EM, Pestonjamasp KN, Bohl BP, et al. (2003). "Spatial and temporal analysis of Rac activation during live neutrophil chemotaxis.". Curr. Biol. 12 (23): 2029–34. doi:10.1016/S0960-9822(02)01334-9. PMID 12477392.
Moon SY, Zang H, Zheng Y (2003). "Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP.". J. Biol. Chem. 278 (6): 4151–9. doi:10.1074/jbc.M207789200. PMID 12454018.
Nakamura T, Komiya M, Sone K, et al. (2003). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules.". Mol. Cell. Biol. 22 (24): 8721–34. doi:10.1128/MCB.22.24.8721-8734.2002. PMID 12446789.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.

[entrez-0] "Entrez Gene: RICS Rho GTPase-activating protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9743.

[pmid12819203-1] ^ ^a ^b ^c ^d ^e ^f Zhao, Chunmei; Ma Hong, Bossy-Wetzel Ella, Lipton Stuart A, Zhang Zhuohua, Feng Gen-Sheng (Sep. 2003). "GC-GAP, a Rho family GTPase-activating protein that interacts with signaling adapters Gab1 and Gab2". J. Biol. Chem. (United States) 278 (36): 34641-53. doi:10.1074/jbc.M304594200. ISSN 0021-9258. PMID 12819203.

[pmid12446789-2] ^ ^a ^b ^c ^d ^e ^f Nakamura, Takeshi; Komiya Misako, Sone Kiyoaki, Hirose Eiji, Gotoh Noriko, Morii Hiroshi, Ohta Yasutaka, Mori Nozomu (Dec. 2002). "Grit, a GTPase-activating protein for the Rho family, regulates neurite extension through association with the TrkA receptor and N-Shc and CrkL/Crk adapter molecules". Mol. Cell. Biol. (United States) 22 (24): 8721-34. ISSN 0270-7306. PMID 12446789.

[pmid12788081-3] Taniguchi, Sachiko; Liu Hui, Nakazawa Takanobu, Yokoyama Kazumasa, Tezuka Tohru, Yamamoto Tadashi (Jun. 2003). "p250GAP, a neural RhoGAP protein, is associated with and phosphorylated by Fyn". Biochem. Biophys. Res. Commun. (United States) 306 (1): 151-5. ISSN 0006-291X. PMID 12788081.

[pmid12454018-4] Moon, Sun Young; Zang Heesuk, Zheng Yi (Feb. 2003). "Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP". J. Biol. Chem. (United States) 278 (6): 4151-9. doi:10.1074/jbc.M207789200. ISSN 0021-9258. PMID 12454018.

[pmid12857875-5] Nakazawa, Takanobu; Watabe Ayako M, Tezuka Tohru, Yoshida Yutaka, Yokoyama Kazumasa, Umemori Hisashi, Inoue Akihiro, Okabe Shigeo, Manabe Toshiya, Yamamoto Tadashi (Jul. 2003). "p250GAP, a novel brain-enriched GTPase-activating protein for Rho family GTPases, is involved in the N-methyl-d-aspartate receptor signaling". Mol. Biol. Cell (United States) 14 (7): 2921-34. doi:10.1091/mbc.E02-09-0623. ISSN 1059-1524. PMID 12857875.

[1]

[2]

[3]

[4]

[5]

[6]