QFE is a three letter acronym which can have meanings in aviation, in software development, and in network usage. It can refer to

• QFE, a Q code used by pilots and air traffic control (ATC)
• A software development acronym for Quick Fix Engineering. This is the Microsoft and Intel term for a hotfix
• A networking hardware acronym standing for Quad Fast Ethernet, a type of vendor-specific network card with four network interfaces, mostly used in Solaris Operating System
• QFE is as acronym for "Qt FTN Message Editor", a message editor for Fidonet
• QFE is an acronym for the words "Quoted for Emphasis", commonly used on messageboards.

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