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Morphological characteristics of pyknosis and other forms of nuclear destruction

Pyknosis, or karyopyknosis, is the irreversible condensation of chromatin in the nucleus of a cell undergoing apoptosis^[1]. It is followed by karyorrhexis, or fragmentation of the nucleus. Pyknosis (from Greek pyknotikos meaning "to condense") is also observed in the maturation of erythrocytes (a red blood cell) and the neutrophil (a type of white blood cell). The maturing metarubicyte (a stage in RBC maturation) will condense its nucleus before expelling it to become a reticulocyte. The maturing neutrophil will condense its nucleus into several connected lobes that stay in the cell until the end of its cell life.

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^ Kroemer G et al. (2009). "Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.". Cell Death and Differentiation 401 (127). http://www.ncbi.nlm.nih.gov/pubmed/18846107?ordinalpos=45&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

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[zamzami-0] Kroemer G et al. (2009). "Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009.". Cell Death and Differentiation 401 (127). http://www.ncbi.nlm.nih.gov/pubmed/18846107?ordinalpos=45&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum.

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